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Integration of Sensor Cells into Hardware Platforms

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Handbook of Cell Biosensors

Abstract

Cell biosensors have shown great potential for their use in various analytical applications, such as environmental monitoring and biomedical diagnostics. The main aspect of this field is the integration of live sensor cells into miniaturized hardware platforms that enable portability of the integrated system and improve its detection performance. Here, the authors review the (1) various hardware platform types that are used for cell biosensors; (2) sensor cell immobilization strategies onto these platforms; (3) transduction mechanisms of the biological response to a bioelectronic signal; and (4) modeling of the sensor cell-hardware platform bioelectronic interface.

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References

  • An R, Zhang D, Chen Y, Cui YZ (2016) A “turn-on” fluorescent and colorimetric sensor for selective detection of Cu2+ in aqueous media and living cells. Sens Actuators B Chem 222:48–54

    Article  CAS  Google Scholar 

  • Bahadir EB, Sezgintürk MK (2016) A review on impedimetric biosensors. Artif Cells Nanomed Biotechnol 44(1):248–262

    Article  CAS  PubMed  Google Scholar 

  • Bayram E, Akyilmaz E (2016) Development of a new microbial biosensor based on conductive polymer/multiwalled carbon nanotube and its application to paracetamol determination. Sens Actuators B Chem 233:409–418

    Article  CAS  Google Scholar 

  • Belkin S (2003) Microbial whole-cell sensing systems of environmental pollutants. Curr Opin Microbiol 6(3):206–212

    Article  CAS  PubMed  Google Scholar 

  • Ben-Yoav H, Biran A, Pedahzur R, Belkin S, Buchinger S, Reifferscheid G, Shacham-Diamand Y (2009a) A whole cell electrochemical biosensor for water genotoxicity bio-detection. Electrochim Acta 54(25):6113–6118

    Article  CAS  Google Scholar 

  • Ben-Yoav H, Elad T, Shlomovits O, Belkin S, Shacham-Diamand Y (2009b) Optical modeling of bioluminescence in whole cell biosensors. Biosens Bioelectron 24(7):1969–1973

    Article  CAS  PubMed  Google Scholar 

  • Ben-Yoav H, Melamed S, Freeman A, Shacham-Diamand Y, Belkin S (2011) Whole-cell biochips for bio-sensing: integration of live cells and inanimate surfaces. Crit Rev Biotechnol 31(4):337–353

    Article  CAS  PubMed  Google Scholar 

  • Ben-Yoav H, Biran A, Sternheim M, Belkin S, Freeman A, Shacham-Diamand Y (2013) Functional modeling of electrochemical whole-cell biosensors. Sens Actuators B Chem 181:479–485

    Article  CAS  Google Scholar 

  • Berezhetskyy A, Durrieu C, Nguyen-Ngoc H, Chovelon J-M, Dzyadevych S, Tran-Minh C (2007) Conductometric biosensor based on whole-cell microalgae for assessment of heavy metals in wastewater. Biopolym Cell 23(6):511–518

    Article  CAS  Google Scholar 

  • Blocki A, Löwenberg C, Jiang Y, Kratz K, Neffe AT, Jung F, Lendlein A (2017) Response of encapsulated cells to a gelatin matrix with varied bulk and microenvironmental elastic properties. Polym Adv Technol 28(10):1245–1251

    Article  CAS  Google Scholar 

  • Bonde S, Berthing T, Madsen MH, Andersen TK, Buch-Månson N, Guo L, Li X, Badique F, Anselme K, Nygård J, Martinez KL (2013) Tuning InAs nanowire density for hek293 cell viability, adhesion, and morphology: perspectives for nanowire-based biosensors. ACS Appl Mater Interfaces 5(21):10510–10519

    Article  CAS  PubMed  Google Scholar 

  • Braham Y, Barhoumi H, Maaref A, Bakhrouf A, Grauby-Heywang C, Cohen-Bouhacina T, Jaffrezic-Renault N (2015) Characterization of urea biosensor based on the immobilization of bacteria proteus mirabilis in interaction with iron oxide nanoparticles on gold electrode. J Biosens Bioelectron 6(1):1000160

    Google Scholar 

  • Bustillo J, Howe R, Muller R (1998) Surface micromachining for microelectromechanical systems. Proc IEEE 86(8):1552–1573

    Article  CAS  Google Scholar 

  • Chen S, Shamsi MH (2017) Biosensors-on-chip: a topical review. J Micromech Microeng 27(8):083001

    Article  CAS  Google Scholar 

  • Cheng Y, Tsao CY, Wu HC, Luo X, Terrell JL, Betz J, Payne GF, Bentley WE, Rubloff GW (2012) Electroaddressing functionalized polysaccharides as model biofilms for interrogating cell signaling. Adv Funct Mater 22(3):519–528

    Article  CAS  Google Scholar 

  • Chouteau C, Dzyadevych S, Durrieu C, Chovelon JM (2005) A bi-enzymatic whole cell conductometric biosensor for heavy metal ions and pesticides detection in water samples. Biosens Bioelectron 21(2):273–281

    Article  CAS  PubMed  Google Scholar 

  • Chuang CH, Lee YC, Huang HS, Hsiao FB, Hsu YM, Wang KH, Ding L, Hsu HJ (2006) 3D microstructures array single-cell-based dep chip for studying apoptosis of U937 & A431 cells. In: Proceedings of 1st IEEE international conference on nano micro engineered and molecular systems (1st IEEE-NEMS), pp 1207–1210

    Google Scholar 

  • De La Rica R, Thompson S, Baldi A, Fernandez-Sanchez C, Drain CM, Matsui H (2009) Label-free cancer cell detection with impedimetric transducers. Anal Chem 81(24):10167–10171

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Deng Y, Yi P, Peng L, Lai X, Lin Z (2014) Experimental investigation on the large-area fabrication of micro-pyramid arrays by roll-to-roll hot embossing on PVC film. J Micromech Microeng 24(4):045023

    Article  CAS  Google Scholar 

  • Dippel AB, Anderson WA, Evans RS, Deutsch S, Hammond MC (2018) Chemiluminescent biosensors for detection of second messenger cyclic di-GMP. ACS Chem Biol 13:1872. https://doi.org/10.1021/acschembio.7b01019. (in print)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Drachuk I, Harbaugh S, Geryak R, Kaplan DL, Tsukruk VV, Kelley-Loughnane N (2017) Immobilization of recombinant E. coli cells in a bacterial cellulose-silk composite matrix to preserve biological function. ACS Biomater Sci Eng 3(10):2278–2292

    Article  CAS  PubMed  Google Scholar 

  • Durrieu C, Ferro Y, Perullini M, Gosset A, Jobbágy M, Bilmes SA (2016) Feasibility of using a translucid inorganic hydrogel to build a biosensor using immobilized algal cells. Environ Sci Pollut Res 23(1):9–13

    Article  CAS  Google Scholar 

  • Efremenko EN, Maslova OV, Kholstov AV, Senko OV, Ismailov AD (2016) Biosensitive element in the form of immobilized luminescent photobacteria for detecting ecotoxicants in aqueous flow-through systems. Luminescence 31:1283–1289

    Article  CAS  PubMed  Google Scholar 

  • Elad T, Lee JH, Belkin S, Gu MB (2008) Microbial whole-cell arrays. Microb Biotechnol 1(2): 137–148

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Eltzov E, Marks RS (2011) Whole-cell aquatic biosensors. Anal Bioanal Chem 400(4):895–913

    Article  CAS  PubMed  Google Scholar 

  • Ferro Y, Perullini M, Jobbagy M, Bilmes SA, Durrieu C (2012) Development of a biosensor for environmental monitoring based on microalgae immobilized in silica hydrogels. Sensors 12(12):16879–16891

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Ghiglione J-F, Martin-Laurent F, Pesce S (2016) Microbial ecotoxicology: an emerging discipline facing contemporary environmental threats. Environ Sci Pollut Res 23(5):3981–3983

    Article  Google Scholar 

  • Gui Q, Lawson T, Shan S, Yan L, Liu Y (2017) The application of whole cell-based biosensors for use in environmental analysis and in medical diagnostics. Sensors-Basel 17(7):1623

    Article  PubMed Central  CAS  Google Scholar 

  • Gutiérrez JC, Amaro F, Díaz S, De Francisco P, Cubas LL, Martín-González A (2011) Ciliate metallothioneins: unique microbial eukaryotic heavy-metal-binder molecules. J Biol Inorg Chem 16(7):1025–1034

    Article  PubMed  CAS  Google Scholar 

  • Gutiérrez JC, Amaro F, Martín-González A (2015) Heavy metal whole-cell biosensors using eukaryotic microorganisms: An updated critical review. Front Microbiol 6:1–8

    Google Scholar 

  • Han KN, Li CA, Seong GH (2013) Microfluidic chips for immunoassays. Annu Rev Anal Chem 6(1):119–141

    Article  CAS  Google Scholar 

  • Hassan SHA, Van Ginkel SW, Hussein MM, Abskharon R, Oh SE (2016) Toxicity assessment using different bioassays and microbial biosensors. Environ Int 92–93:106–118

    Article  PubMed  CAS  Google Scholar 

  • Higson S (2012) Biosensors for medical applications. Woodhead Publishing, Sawston, Cambridge, UK

    Google Scholar 

  • Højris B, Christensen SCB, Albrechtsen HJ, Smith C, Dahlqvist M (2016) A novel, optical, on-line bacteria sensor for monitoring drinking water quality. Sci Rep 6:1–10

    Article  CAS  Google Scholar 

  • Hu Y, Zhao F, Hu S, Dong Y, Li D, Su Z (2017) A novel turn-on colorimetric and fluorescent sensor for Fe3+ and its application in living cells. J Photochem Photobiol A Chem 332(3):351–356

    Article  CAS  Google Scholar 

  • Ionescu RE, Abu-Rabeah K, Cosnier S, Durrieu C, Chovelon JM, Marks RS (2006) Amperometric algal chlorella vulgaris cell biosensors based on alginate and polypyrrole-alginate gels. Electroanalysis 18(11):1041–1046

    Article  CAS  Google Scholar 

  • Jaffrezic-Renault N, Dzyadevych S (2008) Conductometric microbiosensors for environmental monitoring. Sensors-Basel 8(4):2569

    Article  PubMed  PubMed Central  Google Scholar 

  • Jiang H, Jiang D, Shao J, Sun X, Wang J (2016) High-throughput living cell-based optical biosensor for detection of bacterial lipopolysaccharide (LPS) using a red fluorescent protein reporter system. Sci Rep 6:1–12

    CAS  Google Scholar 

  • Kanyong P, Hughes G, Pemberton RM, Jackson SK, Hart JP (2016) Amperometric screen-printed galactose biosensor for cell toxicity applications. Anal Lett 49(2):236–244

    Article  CAS  Google Scholar 

  • Kaspar M, Stadler H, Weiß T, Ziegler C (2000) Thickness shear mode resonators (“mass-sensitive devices”) in bioanalysis. Fresenius J Anal Chem 366(6):602–610

    Article  CAS  PubMed  Google Scholar 

  • Khademhosseini A, Yeh J, Jon S, Eng G, Suh KY, Burdick JA, Langer R (2004) Molded polyethylene glycol microstructures for capturing cells within microfluidic channels. Lab Chip 4(5):425–425

    Article  CAS  PubMed  Google Scholar 

  • Khan S, Lorenzelli L, Dahiya RS (2015) Technologies for printing sensors and electronics over large flexible substrates: a review. IEEE Sensors J 15(6):3164–3185

    Article  Google Scholar 

  • Kim HJ, Bennetto HP, Halablab MA, Choi C, Yoon S (2006) Performance of an electrochemical sensor with different types of liposomal mediators for the detection of hemolytic bacteria. Sens Actuators B Chem 119(1):143–149

    Article  CAS  Google Scholar 

  • Kim SD, Koo Y, Yun Y (2017) A smartphone-based automatic measurement method for colorimetric pH detection using a color adaptation algorithm. Sensors 17(7):1604

    Google Scholar 

  • Kim HJ, Jeong H, Lee SJ (2018) Synthetic biology for microbial heavy metal biosensors. Anal Bioanal Chem 410(4):1191–1203

    Article  CAS  PubMed  Google Scholar 

  • Kovacs GTA, Maluf NI, Petersen KE (1998) Bulk micromachining of silicon. Proc IEEE 86(8): 1536–1551

    Article  CAS  Google Scholar 

  • Kremers G-J, Gilbert SG, Cranfill PJ, Davidson MW, Piston DW (2011) Fluorescent proteins at a glance. J Cell Sci 124(2):157–160

    Article  CAS  PubMed  Google Scholar 

  • Krotz G, Legner W, Wapner C, Moller H, Sonntag H, Muller G (1982) Silicon as a mechanical material. In: Proceedings of the international solid-state sensors and actuators conference – transducers ’95, vol 2, no 5, pp 186–189

    Google Scholar 

  • La Rosa SL, Solheim M, Diep DB, Nes IF, Brede DA (2015) Bioluminescence based biosensors for quantitative detection of enterococcal peptide – pheromone activity reveal inter-strain telesensing in vivo during polymicrobial systemic infection. Sci Rep 5:8339–8339

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  • Lafleur JP, Jönsson A, Senkbeil S, Kutter JP (2016) Recent advances in lab-on-a-chip for biosensing applications. Biosens Bioelectron 76:213–233

    Article  CAS  PubMed  Google Scholar 

  • Lawrence AJ, Moores GR (1972) Conductimetry in enzyme studies. Eur J Biochem 24(3):538–546

    Article  CAS  PubMed  Google Scholar 

  • Li M, Glawe JD, Green H, Mills DK, Mcshane MJ, Gale BK (2000) Effect of high-aspect-ratio microstructures on cell growth and attachment. In: Proceedings of the 1st annual international IEEE-EMBS special topic conference on microtechnologies in medicine and biology, pp 531–536

    Google Scholar 

  • Lim HG, Jang S, Jang S, Seo SW, Jung GY (2018) Design and optimization of genetically encoded biosensors for high-throughput screening of chemicals. Curr Opin Biotechnol 54:18–25

    Article  CAS  PubMed  Google Scholar 

  • Liu J, Mattiasson B (2002) Microbial bod sensors for wastewater analysis. Water Res 36(15): 3786–3802

    Article  CAS  PubMed  Google Scholar 

  • Liu Q, Cai H, Xu Y, Xiao L, Yang M, Wang P (2007) Detection of heavy metal toxicity using cardiac cell-based biosensor. Biosens Bioelectron 22(12):3224–3229

    Article  CAS  PubMed  Google Scholar 

  • Liu L, Luo C, Ni X, Wang L, Yamauchi K, Nomura SM, Nakatsuji N, Chen Y (2010) A micro-channel-well system for culture and differentiation of embryonic stem cells on different types of substrate. Biomed Microdevices 12(3):505–511

    Article  CAS  PubMed  Google Scholar 

  • Liu YL, Qin Y, Jin ZH, Hu XB, Chen MM, Liu R, Amatore C, Huang WH (2017) A stretchable electrochemical sensor for inducing and monitoring cell mechanotransduction in real time. Angew Chem Int Ed 56(32):9454–9458

    Article  CAS  Google Scholar 

  • Liu C, Xu Y, Han X, Chang X (2018) The fabrication and the use of immobilized cells as test organisms in a ferricyanide-based toxicity biosensor. Environ Toxicol Chem 37(2):329–335

    Article  CAS  PubMed  Google Scholar 

  • Mamishev AV, Sundara-Rajan K, Yang F, Du Y, Zahn M (2004) Interdigital sensors and transducers. Proc IEEE 92(5):808–844

    Article  CAS  Google Scholar 

  • Marx KA, Zhou T, Montrone A, Schulze H, Braunhut SJ (2001) A quartz crystal microbalance cell biosensor: detection of microtubule alterations in living cells at nm nocodazole concentrations. Biosens Bioelectron 16(9–12):773–782

    Article  CAS  PubMed  Google Scholar 

  • Muramatsu H, Kajiwara K, Tamiya E, Karube I (1986) Piezoelectric immuno sensor for the detection of candida albicans microbes. Anal Chim Acta 188:257–261

    Article  Google Scholar 

  • Ng K, Gao B, Yong KW, Li Y, Shi M, Zhao X, Li Z, Zhang XH, Pingguan-Murphy B, Yang H, Xu F (2017) Paper-based cell culture platform and its emerging biomedical applications. Mater Today 20(1):32–44

    Article  CAS  Google Scholar 

  • Ni M, Tong WH, Choudhury D, Rahim NA, Iliescu C, Yu H (2009) Cell culture on mems platforms: a review. Int J Mol Sci 10(12):5411–5441

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Olsen EV, Pathirana ST, Samoylov AM, Barbaree JM, Chin BA, Neely WC, Vodyanoy V (2003) Specific and selective biosensor for salmonella and its detection in the environment. J Microbiol Methods 53(2):273–285

    Article  CAS  PubMed  Google Scholar 

  • Partovinia A, Rasekh B (2018) Review of the immobilized microbial cell systems for bioremediation of petroleum hydrocarbons polluted environments. Crit Rev Environ Sci Technol 48(1):1–38

    Article  CAS  Google Scholar 

  • Perullini M, Rivero MM, Jobbágy M, Mentaberry A, Bilmes SA (2007) Plant cell proliferation inside an inorganic host. J Biotechnol 127(3):542–548

    Article  CAS  PubMed  Google Scholar 

  • Peterson SL, Mcdonald A, Gourley PL, Sasaki DY (2005) Poly(dimethylsiloxane) thin films as biocompatible coatings for microfluidic devices: cell culture and flow studies with glial cells. J Biomed Mater Res A 72(1):10–18

    Article  PubMed  CAS  Google Scholar 

  • Qin D, Xia Y, Whitesides GM (2010) Soft lithography for micro-and nanoscale patterning. Nat Protoc 5(3):491

    Article  CAS  PubMed  Google Scholar 

  • Rodriguez-Mozaz S, Lopez De Alda MJ, Barceló D (2006) Biosensors as useful tools for environmental analysis and monitoring. Anal Bioanal Chem 386(4):1025–1041

    Article  CAS  PubMed  Google Scholar 

  • Romero-Vargas Castrillon S, Perreault FO, De Faria AF, Elimelech M (2015) Interaction of graphene oxide with bacterial cell membranes: insights from force spectroscopy. Environ Sci Technol Lett 2(4):112–117

    Article  CAS  Google Scholar 

  • Saem S, Zhu Y, Luu H, Moran-Mirabal J (2017) Bench-top fabrication of an all-pdms microfluidic electrochemical cell sensor integrating micro/nanostructured electrodes. Sensors 17(4):732

    Google Scholar 

  • Sekoai PT, Awosusi AA, Yoro KO, Singo M, Oloye O, Ayeni AO, Bodunrin M, Daramola MO (2018) Microbial cell immobilization in biohydrogen production: a short overview. Crit Rev Biotechnol 38(2):157–171

    Article  CAS  PubMed  Google Scholar 

  • Shacham-Diamand Y, Belkin S, Rishpon J, Elad T, Melamed S, Biran A, Yagur-Kroll S, Almog R, Daniel R, Ben-Yoav H, Rabner A, Vernick S, Elman N, Popovtzer R (2010) Optical and electrical interfacing technologies for living cell bio-chips. Curr Pharm Biotechnol 11(4): 376–383

    Article  CAS  PubMed  Google Scholar 

  • Shacham-Diamand Y, Almog R, Daniel R, Rabner A, Popovtzer R (2011) Nano-bio interfacing with living cell biochips. In: Sattler KD (ed) Handbook of nanophysics: nanomedicine and nanorobotics. CRC Press, Boca Raton

    Google Scholar 

  • Si R-W, Yang Y, Yu Y-Y, Han S, Zhang C-L, Sun D-Z, Zhai D-D, Liu X, Yong Y-C (2016) Wiring bacterial electron flow for sensitive whole-cell amperometric detection of riboflavin. Anal Chem 88(22):11222–11228

    Article  CAS  PubMed  Google Scholar 

  • Su L, Jia W, Hou C, Lei Y (2011) Microbial biosensors: a review. Biosens Bioelectron 26(5):1788–1799

    Article  CAS  PubMed  Google Scholar 

  • Thrush E, Levi O, Cook LJ, Deich J, Kurtz A, Smith SJ, Moerner WE, Harris JS (2005) Monolithically integrated semiconductor fluorescence sensor for microfluidic applications. Sens Actuators B Chem 105(2):393–399

    Article  CAS  Google Scholar 

  • Tran TB, Son SJ, Min J (2016) Nanomaterials in label-free impedimetric biosensor: current process and future perspectives. Biochip J 10(4):318–330

    Article  CAS  Google Scholar 

  • Van Der Meer JR, Belkin S (2010) Where microbiology meets microengineering: design and applications of reporter bacteria. Nat Rev Microbiol 8(7):511–522

    Article  PubMed  CAS  Google Scholar 

  • Verma N, Sharma R, Kumar S (2016) Advancement towards microfluidic approach to develop economical disposable optical biosensor for lead detection. Austin J Biosens Bioelectron 2(2):1021

    Google Scholar 

  • Wang X, Ben Ahmed N, S Alvarez G, V Tuttolomondo M, Hélary C, F Desimone M, Coradin T (2015) Sol-gel encapsulation of biomolecules and cells for medicinal applications. Curr Top Med Chem 15(3):223–244

    Article  PubMed  CAS  Google Scholar 

  • Wen G, Wen X, Shuang S, Choi MMF (2014) Whole-cell biosensor for determination of methanol. Sens Actuators B Chem 201:586–591

    Article  CAS  Google Scholar 

  • Wong LS, Lee YH, Surif S (2013) Whole cell biosensor using anabaena torulosa with optical transduction for environmental toxicity evaluation. J Sens 2013:1

    Article  CAS  Google Scholar 

  • Xia YN, Whitesides GM (1998) Soft lithography. Annu Rev Mater Sci 37(5):551–575

    Google Scholar 

  • Yoetz-Kopelman T, Dror Y, Shacham-Diamand Y, Freeman A (2016) “Cells-on-beads”: a novel immobilization approach for the construction of whole-cell amperometric biosensors. Sens Actuators B Chem 232:758–764

    Article  CAS  Google Scholar 

  • Zeck G, Fromherz P (2001) Noninvasive neuroelectronic interfacing with synaptically connected snail neurons immobilized on a semiconductor chip. PNAS 98(18):10457–10462

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Zhang Y, Bai X, Wang X, Shiu KK, Zhu Y, Jiang H (2014) Highly sensitive graphene-pt nanocomposites amperometric biosensor and its application in living cell H2O2 detection. Anal Chem 86(19):9459–9465

    Article  CAS  PubMed  Google Scholar 

  • Zhu M, Baffou G, Meyerbröker N, Polleux J (2012) Micropatterning thermoplasmonic gold nanoarrays to manipulate cell adhesion. ACS Nano 6(8):7227–7233

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Nanobioelectronics Laboratory (NBEL), Department of Biomedical Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel

    Rajendra P. Shukla & Hadar Ben-Yoav

  2. Department of Biomedical Engineering, Ben-Gurion University of the Negev, Beer-Sheva, Israel

    Avia Lavon

Authors
  1. Rajendra P. Shukla
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  2. Avia Lavon
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  3. Hadar Ben-Yoav
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Corresponding author

Correspondence to Hadar Ben-Yoav .

Editor information

Editors and Affiliations

  1. UMR CNRS 6144 GEPEA, Institut Universitaire de Technologie, La Roche sur Yon, France

    Gérald Thouand

Section Editor information

  1. Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel

    Shimshon Belkin

  2. University of Miami, Miami, FL, USA

    Sylvia Daunert

  3. Imperial College London, London, UK

    Paul Freemont

  4. Université catholique de Louvain, Mons, Belgium

    Julie Hermans

  5. School of Bioscience and Biotechnology, Tokyo University of Technology, Hachioji-Shi, Tokyo, Japan

    Isao Karube

  6. Ecole Polytechnique de Montreal, Montréal, QC, Canada

    Sylvain Martel

  7. Department of Chemistry “G. Ciamician”, University of Bologna, Bologna, Italy

    Elisa Michelini

  8. Dept of Chemistry “G. Ciamician”, University of Bologna, BOLOGNA, Bologna, Italy

    Aldo Roda

  9. Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel

    Shimshon Belkin

  10. Faculty of Medicine, Imperial College, London, UK

    Paul Freemont

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Shukla, R.P., Lavon, A., Ben-Yoav, H. (2022). Integration of Sensor Cells into Hardware Platforms. In: Thouand, G. (eds) Handbook of Cell Biosensors. Springer, Cham. https://doi.org/10.1007/978-3-030-23217-7_122

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