Abstract
Basic knowledge of retinal autofluorescence lifetime features can be gained by investigating cohorts of healthy eyes of subjects over a broad age range. Comparison with fundus autofluorescence intensity imaging and optical coherence tomography allows to correlate findings of FLIO with conventional imaging methods. Individual lifetime parameters can be analyzed in both spectral channels generating characteristic fluorescence lifetime distribution patterns. In general, the shortest FLIO lifetimes are located in the macular center. The optic nerve head and the vessels feature longer lifetimes compared to the surrounding retina. With age, FLIO lifetimes increase. Lens opacities lead to a prolongation of fluorescence lifetimes independent of age in both spectral channels. FLIO data of healthy retinae provide reference values to compare FLIO changes in retinal diseases.
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Dysli, C., Dysli, M. (2019). FLIO in the Healthy Eye. In: Zinkernagel, M., Dysli, C. (eds) Fluorescence Lifetime Imaging Ophthalmoscopy. Springer, Cham. https://doi.org/10.1007/978-3-030-22878-1_8
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DOI: https://doi.org/10.1007/978-3-030-22878-1_8
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