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Anti-interferon-γ Therapy for Cytokine Storm Syndromes

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Cytokine Storm Syndrome

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Abstract

A vast body of evidence provides support to a central role of exaggerated production of interferon-γ (IFN-γ) in causing hypercytokinemia and signs and symptoms of hemophagocytic lymphohistiocytosis (HLH). In this chapter, we describe briefly the roles of IFN-γ in innate and adaptive immunity and in host defense, summarize results from animal models of primary HLH and secondary HLH with a particular emphasis on targeted therapeutic approaches, review data on biomarkers associated with activation of the IFN-γ pathway, and discuss initial efficacy and safety results of IFN-γ neutralization in humans.

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Authors and Affiliations

  1. Division of Rheumatology, Ospedale Pediatrico Bambino Gesù, Rome, Italy

    Fabrizio De Benedetti

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  1. Fabrizio De Benedetti
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Correspondence to Fabrizio De Benedetti .

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Editors and Affiliations

  1. UAB School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA

    Randy Q. Cron

  2. Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA

    Edward M. Behrens

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De Benedetti, F. (2019). Anti-interferon-γ Therapy for Cytokine Storm Syndromes. In: Cron, R., Behrens, E. (eds) Cytokine Storm Syndrome. Springer, Cham. https://doi.org/10.1007/978-3-030-22094-5_33

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