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S100 Proteins

Encyclopedia of Molecular Pharmacology

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Abstract

S100 proteins are the largest subgroup within the superfamily of Ca2+-binding proteins characterized by the specific Ca2+-binding motif, the EF-hand. S100 proteins are closely associated with cardiovascular diseases, various types of cancer, inflammation, autoimmune pathologies, and brain disorders. Mutations in S100A3 and S100A13 are linked to the pathophysiology of pulmonary fibrosis, a disease resulting in inflammation, fibrosis, and eventually death. S100 proteins are of great clinical use as biomarkers and potential drug targets, helping to improve the diagnosis of those human diseases in children and adults, leading to more selective therapeutic interventions.

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References

  • Al-Mutairy EA et al (2019) An atypical pulmonary fibrosis is associated with co-inheritance of mutations in the calcium binding protein genes S100A3 and S100A13. Eur Respir J. https://doi.org/10.1183/13993003.02041-2018

    CAS  PubMed  Google Scholar 

  • Ambartsumian N et al (2019) The multifaceted S100A4 protein in cancer and inflammation. In: Heizmann CW (ed) Calcium-binding proteins of the EF-hand superfamily: from basics to medical applications. Methods in molecular biology, vol 1929. Springer Protocols, Humana Press, New York

    Google Scholar 

  • Arumugam T et al (2013) Designing and developing S100P inhibitor 5-methyl cromolyn (C5OH) for pancreatic cancer therapy. Mol Cancer Ther 12:654–662

    CAS  PubMed  PubMed Central  Google Scholar 

  • Awad SM et al (2018) Serum levels of psoriasin (S100A7) and koebnerisin (S100A15) as potential markers of atherosclerosis in patients with psoriasis. Clin Exp Dermatol 43:262–267

    CAS  PubMed  Google Scholar 

  • Birlea SA (2017) S100B: correlation with active vitiligo depigmentation. J Invest Dermatol 137:1408–1410

    CAS  PubMed  Google Scholar 

  • Bresnick AR et al (2015) S100 proteins in cancer. Nat Rev Cancer 15:96–109

    CAS  PubMed  PubMed Central  Google Scholar 

  • Calderone V et al (2019) Reviewing the crystal structure of S100Z and other members of the S100 family: implications in calcium-regulated quaternary structure. In: Heizmann CW (ed) Calcium-binding proteins of the EF-hand superfamily: from basics to medical applications. Methods molecular biology, vol 1929. Springer Protocols, Humana Press, New York, pp 487–499

    Google Scholar 

  • Cavalier MC et al (2014) Covalent small molecule inhibitors of Ca(2+)-bound S100B. Biochemistry 53:6628–6640

    CAS  PubMed  PubMed Central  Google Scholar 

  • Cho CC et al (2016) Pentamidine blocks the interaction between mutant S100A5 and RAGE V domain and inhibits the RAGE signaling pathway. Biochem Biophys Commun 477:188–194

    CAS  Google Scholar 

  • D’Amico F et al (2016) S100A7: a rAMPing up AMP molecule in psoriasis. Cytokine Growth Factor Rev 32:97–104

    PubMed  Google Scholar 

  • Donato R et al (2002) Functions of S100 proteins. Curr Mol Med 13:24–57

    Google Scholar 

  • Fritz G et al (2002) The crystal structure of the metal-free human EF-hand protein S100A3 at 1.7-A resolution. J Biol Chem 277:33092–33098

    CAS  PubMed  Google Scholar 

  • Gebhardt C et al (2006) S100A8 and S100A9 in inflammation and cancer. Biochem Pharmacol 72:1622–1631

    CAS  PubMed  Google Scholar 

  • Hansen MT et al (2014) A link between inflammation and metastasis: serum amyloid A1 and A3 induce metastasis, and are targets of metastasis-inducing S100A4. Oncogene. https://doi.org/10.1038/onc.2013.568

    PubMed  Google Scholar 

  • Heizmann CW (2019a) S100 proteins: diagnostic and prognostic biomarkers in laboratory medicine. Biochim Biophys Acta Mol Cell Res 1866:1197–1206

    CAS  PubMed  Google Scholar 

  • Heizmann CW (2019b) Calcium-binding proteins of the EF-hand superfamily: from basics to medical applications. Methods molecular biology, vol 1929. Springer Protocols, Humana Press, New York, pp 157–186

    Google Scholar 

  • Holzinger D et al (2019) Alarmins of the S100-family in juvenile autoimmune and auto-inflammatory diseases. Front Immunol 10:182. https://doi.org/10.03389/fimmu.201900182.eCollection

    CAS  PubMed  PubMed Central  Google Scholar 

  • Khan MI et al (2018) S100B as an antagonist to block the interaction between S100A1 and the RAGE V domain. PLoS One 13(2):e0190545

    PubMed  PubMed Central  Google Scholar 

  • Leclerc E, Heizmann CW (2011) The importance of Ca2+/Zn2+-signaling S100 proteins and their receptor RAGE in translational medicine: impact on diagnostics and therapy in human disorders. Front Biosci S3:1232–1262

    CAS  Google Scholar 

  • Lee DH et al (2016) Discovery at the interface: towards novel anti-proliferative agents targeting human estrogen receptor/S100 interactions. Cell Cycle 15:2806–2818

    CAS  PubMed  PubMed Central  Google Scholar 

  • Marenholz I et al (2004) S100 proteins in mouse and man: from evolution to function and pathology (including an update of the nomenclature). Biochem Biophys Res Commun 322:111–1122

    Google Scholar 

  • Maurakis S et al (2019) The novel interaction between Neisseria gonorrhoeae TdfJ and human S100A7 allows gonococci to subvert host Zinc restriction. PLoS Pathog. https://doi.org/10.1371/journal.ppat.1007937

    CAS  PubMed  PubMed Central  Google Scholar 

  • Moroz OV et al (2002) The structure of S100A12 in a hexameric form and its proposed role in receptor signaling. Acta Crystallogr D Biol Crystallogr 58:407–413

    CAS  PubMed  Google Scholar 

  • Ostendorp T et al (2007) Structural and functional insights into RAGE activation by multimeric S100B. EMBO J 26:3868–3878

    CAS  PubMed  PubMed Central  Google Scholar 

  • Padilla L et al (2017) S100A7: from mechanism to cancer therapy. Oncogene 36:6749–6761

    CAS  PubMed  Google Scholar 

  • Penumutchu SR et al (2014) Interaction between S100P and the anti-allergy drug cromolyn. Biochem Biophys Res Commun 454:404–409

    CAS  PubMed  Google Scholar 

  • Pleger ST et al (2007) Stable myocardial-specific AAV6-S100A1 gene therapy results in chronic functional heart failure rescue. Circulation 115:2506–2515

    CAS  PubMed  Google Scholar 

  • Riuzzi F et al (2019) S100 proteins in obesity: liaisons dangereuses. Cell Mol Life Sci. https://doi.org/10.1007/s00018-019-03257.4

  • Spratt DE et al (2019) A subset of calcium-binding S100 proteins show preferential heterodimerization. FEBS J 286:1859–1876

    CAS  PubMed  Google Scholar 

  • Syed DN et al (2018) Ousting RAGE in melanoma: a viable therapeutic target? Semin Cancer Biol 49:20–28

    CAS  PubMed  Google Scholar 

  • Vogl T et al (2018) Autoinhibitory regulation of S100A8/S100A9 alarmin activity locally restricts sterile imflammation. J Clin Invest. https://doi.org/10.1172/JCI89867

    PubMed  Google Scholar 

  • Wang W et al (2014) Differential effects of S100 proteins A2 and A6 on cardiac Ca2+ cycling and contractile performance. J Mol Cell Cardiol 72:117–125

    CAS  PubMed  PubMed Central  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Pediatrics, Division of Clinical Chemistry and Biochemistry, University of Zürich, Zürich, Switzerland

    Claus W. Heizmann

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  1. Claus W. Heizmann
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Correspondence to Claus W. Heizmann .

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Editors and Affiliations

  1. Max-Planck-Institut Herz/Lungenforschg., Bad Nauheim, Hessen, Germany

    Stefan Offermanns

  2. Presidential Office, Friedrich-Schiller University Jena, Jena, Thüringen, Germany

    Walter Rosenthal

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Heizmann, C.W. (2020). S100 Proteins. In: Offermanns, S., Rosenthal, W. (eds) Encyclopedia of Molecular Pharmacology. Springer, Cham. https://doi.org/10.1007/978-3-030-21573-6_225-1

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  • DOI: https://doi.org/10.1007/978-3-030-21573-6_225-1

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-21573-6

  • Online ISBN: 978-3-030-21573-6

  • eBook Packages: Springer Reference Biomedicine and Life SciencesReference Module Biomedical and Life Sciences

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Chapter history

  1. Latest

    S100 Proteins
    Published:
    02 September 2021

    DOI: https://doi.org/10.1007/978-3-030-21573-6_225-2

  2. Original

    S100 Proteins
    Published:
    13 May 2020

    DOI: https://doi.org/10.1007/978-3-030-21573-6_225-1

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