Abstract
Chronic nonbacterial osteomyelitis (CNO) covers a wide clinical spectrum with mild courses of short duration with inflammation of single bones at one end, and chronically active or recurrent bone inflammation with symmetric involvement of multiple bones at the other
Lack of response to antibiotic treatment and absence of B symptoms in a chronic course, complete or partial symptomatic response to NSAIDs, flares after discontinuation, sterile cultures of bone tissue, and inflammatory infiltrates in histopathology, support a diagnosis of CNO in a patient with chronic osteomyelitis
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Hedrich, C.M. (2019). Bone Pain in Upper Leg, Hip, Lower Back. In: Rezaei, N. (eds) Pediatric Immunology. Springer, Cham. https://doi.org/10.1007/978-3-030-21262-9_108
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