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Nanobiomaterial Advances in Cardiovascular Tissue Engineering

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Cardiovascular Regenerative Medicine

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Abstract

Myocardial infarction (MI) is projected to increase globally in the coming decades. The long-term outlook for patients with ischemic heart injury undergoing current treatment modalities is bleak, due to the lack of regenerative capacity of native heart tissue. Tissue engineering and regenerative medicine have developed numerous strategies to repair or replace injured myocardium. One of the most promising strategies to date is the attempt to engineer tissues and cells at the nanoscale by utilizing nanobiomaterials to mimic the native nanoscale structure of the heart. Nanobiomaterials have proliferated enormously in the past few decades and have great potential for creating biomimetic systems that can replace or repair injured myocardium. Tissue engineering scaffolds with precisely controlled nanotopography, electrically conductive nanomaterials with the potential for mimicking conductive pathways in the heart, and numerous nanocarriers for targeted cardiac drug delivery have now been achieved. In this chapter we review the rationale for engineering biological tissues at the nanoscale as well as recent applications in nanofabrication and nanomedicine for cardiac regeneration.

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Acknowledgments

This work was supported by American Heart Association grant # 17SDG33660925 / P.P.S.S. Abadi /2017.

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Authors and Affiliations

  1. Department of Mechanical Engineering-Engineering Mechanics, Michigan Technological University, Houghton, MI, USA

    Michael J. Hill & Parisa P. S. S. Abadi

  2. Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

    Morteza Mahmoudi

  3. Precision Health Program, Department of Radiology, College of Human Medicine, Michigan State University, East Lansing, MI, USA

    Morteza Mahmoudi

  4. Department of Biomedical Engineering, Department of Materials Science and Engineering, Michigan Technological University, Houghton, MI, USA

    Parisa P. S. S. Abadi

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  1. Michael J. Hill
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  3. Parisa P. S. S. Abadi
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Correspondence to Parisa P. S. S. Abadi .

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Editors and Affiliations

  1. Department of Biomedical Engineering, Emory University School of Medicine and Georgia Institute of Technology, Atlanta, GA, USA

    Vahid Serpooshan

  2. Cardiovascular Institute and Department of Medicine, Division of Cardiovascular Medicine, Stanford University, Stanford, CA, USA

    Sean M. Wu

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Hill, M.J., Mahmoudi, M., Abadi, P.P.S.S. (2019). Nanobiomaterial Advances in Cardiovascular Tissue Engineering. In: Serpooshan, V., Wu, S. (eds) Cardiovascular Regenerative Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-20047-3_5

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