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Bone Repair and Regeneration Are Regulated by the Wnt Signaling Pathway

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Regenerative Medicine and Plastic Surgery

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Abstract

The Wnt signaling pathway is central to a large number of diverse cellular processes during embryological development, including those involved in the formation of bone and cartilage. Wnt signaling continues to play a critical role in the homeostasis, repair, and regeneration of bone in adults. Imbalances in this highly conserved and complex system contribute to a number of diseases, including impaired bone healing, autoimmune disease, and cancer. Critical-sized skeletal defects represent a major challenge to the reconstructive surgeon and are often associated with significant morbidity. The Wnt pathway is an attractive therapeutic target with potential to directly modulate stem cells responsible for skeletal tissue regeneration. Recent research indicates that Wnt ligands are able to promote bone growth, suggesting that Wnt factors could be used to stimulate bone healing of nonunions and large bony defects. This chapter explores the essential role of the Wnt pathway in bone regeneration.

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Authors and Affiliations

  1. Department of Plastic Surgery, BG University Hospital Bergmannsheil, Ruhr University Bochum, Bochum, Germany

    Khosrow Siamak Houschyar, Kamran Harati, Christoph Wallner, Marcus Lehnhardt & Björn Behr

  2. Burn Unit, Department for Plastic and Hand Surgery, Trauma Center Bergmannstrost Halle, Halle (Saale), Germany

    Khosrow Siamak Houschyar

  3. Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford School of Medicine, Stanford, CA, USA

    Zeshaan N. Maan, Malcolm P. Chelliah & Mimi R. Borrelli

  4. Department of Plastic and Hand Surgery, Burn Center-Clinic St. Georg, Leipzig, Germany

    Susanne Rein

  5. Department of Surgery, Shriners Hospital for Children-Galveston, University of Texas Medical Branch, Galveston, TX, USA

    Christian Tapking

  6. Department of Hand, Plastic and Reconstructive Surgery, Burn Trauma Center, BG Trauma Center Ludwigshafen, University of Heidelberg, Heidelberg, Germany

    Christian Tapking

  7. Department of Plastic and Hand Surgery, Burn Unit, Trauma Center Bergmannstrost Halle, Halle, Germany

    Georg Reumuth

  8. Department of Plastic Surgery and Hand Surgery, Gemeinschaftskrankenhaus Havelhoehe, Teaching Hospital of the Charité Berlin, Berlin, Germany

    Gerrit Grieb & Frank Siemers

  9. Department for Plastic Surgery and Hand Surgery, Division of Experimental Plastic Surgery, Technical University of Munich, Munich, Germany

    Dominik Duscher

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  1. Department for Plastic Surgery and Hand Surgery, Division of Experimental Plastic Surgery, Technical University of Munich, Munich, Germany

    Dominik Duscher

  2. Private Practice, Tustin, CA, USA

    Melvin A. Shiffman

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Houschyar, K.S. et al. (2019). Bone Repair and Regeneration Are Regulated by the Wnt Signaling Pathway. In: Duscher, D., Shiffman, M.A. (eds) Regenerative Medicine and Plastic Surgery. Springer, Cham. https://doi.org/10.1007/978-3-030-19962-3_17

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