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Uveal Melanoma: Resection Techniques

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Clinical Ophthalmic Oncology

Abstract

Local resection of uveal melanoma can be performed transretinally with a vitreous cutter (i.e., endoresection) or trans-sclerally (i.e., exoresection). These operations can be undertaken as primary procedures, with or without neoadjuvant radiotherapy, or they can be performed as treatment for exudative and neovascular complications (i.e., ‘toxic tumor syndrome’).

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References

  1. Lagrange F. Traite des tumeurs de l’oeil de l’orbite et des annexes. Paris: Steinheil; 1901.

    Google Scholar 

  2. Stallard HB. Partial choroidectomy. Br J Ophthalmol. 1966;50(11):660–2.

    Article  CAS  Google Scholar 

  3. Damato BE, Stewart JM, Afshar AR, et al. Surgical resection of choroidal melanoma. In: Schachat AP, editor. Ryan’s Retina. 3. 6 ed. Philadelphia: Elsevier; 2018. p. 2591–600.

    Google Scholar 

  4. Konstantinidis L, Groenewald C, Coupland SE, et al. Long-term outcome of primary endoresection of choroidal melanoma. Br J Ophthalmol. 2014;98(1):82–5.

    Article  Google Scholar 

  5. Peyman GA, Gremillion CM. Eye wall resection in the management of uveal neoplasms. Jpn J Ophthalmol. 1989;33(4):458–71.

    CAS  PubMed  Google Scholar 

  6. Shields JA, Shields CL, Shah P, et al. Partial lamellar sclerouvectomy for ciliary body and choroidal tumors. Ophthalmology. 1991;98(6):971–83.

    Article  CAS  Google Scholar 

  7. Kertes PJ, Johnson JC, Peyman GA. Internal resection of posterior uveal melanomas. Br J Ophthalmol. 1998;82(10):1147–53.

    Article  CAS  Google Scholar 

  8. Garcia-Arumi J, Leila M, Zapata MA, et al. Endoresection technique with/without brachytherapy for management of high posterior choroidal melanoma: extended follow-up results. Retina. 2015;35(4):628–37.

    Article  Google Scholar 

  9. Schilling H, Bornfeld N, Talies S, et al. Endoresection of large uveal melanomas after pretreatment by single-dose stereotactic convergence irradiation with the leksell gamma knife--first experience on 46 cases. Klinische Monatsblatter fur Augenheilkunde. 2006;223(6):513–20.

    Article  CAS  Google Scholar 

  10. Char DH, Miller T, Crawford JB. Uveal tumour resection. Br J Ophthalmol. 2001;85(10):1213–9.

    Article  CAS  Google Scholar 

  11. Biewald E, Lautner H, Gok M, et al. Endoresection of large uveal melanomas: clinical results in a consecutive series of 200 cases. Br J Ophthalmol. 2017;101(2):204–8.

    Article  Google Scholar 

  12. Damato B, Kacperek A, Chopra M, et al. Proton beam radiotherapy of iris melanoma. Int J Radiat Oncol Biol Phys. 2005;63(1):109–15.

    Article  Google Scholar 

  13. Shields CL, Naseripour M, Shields JA, et al. Custom-designed plaque radiotherapy for nonresectable iris melanoma in 38 patients: tumor control and ocular complications. Am J Ophthalmol. 2003;135(5):648–56.

    Article  Google Scholar 

  14. Thariat J, Rahmi A, Salleron J, et al. Proton beam therapy for iris melanomas in 107 patients. Ophthalmology. 2018;125(4):606–14.

    Article  Google Scholar 

  15. Singh AD. Small incision guarded hydroaspiration of iris lesions. Br J Ophthalmol. 2017;101(11):1570–5.

    Article  Google Scholar 

  16. Damato BE, Foulds WS. Ciliary body tumours and their management. Trans Ophthalmol Soc U K. 1986;105(Pt 2):257–64.

    PubMed  Google Scholar 

  17. Gunduz K, Shields CL, Shields JA, et al. Plaque radiotherapy of uveal melanoma with predominant ciliary body involvement. Arch Ophthalmol. 1999;117(2):170–7.

    Article  CAS  Google Scholar 

  18. Rospond-Kubiak I, Damato B. The surgical approach to the management of anterior uveal melanomas. Eye. 2014;28(6):741–7.

    Article  CAS  Google Scholar 

  19. Naumann GO, Rummelt V. Block excision of tumors of the anterior uvea. Report on 68 consecutive patients. Ophthalmology. 1996;103(12):2017–27; discussion 27–8

    Article  CAS  Google Scholar 

  20. Damato BE, Paul J, Foulds WS. Predictive factors of visual outcome after local resection of choroidal melanoma. Br J Ophthalmol. 1993;77(10):616–23.

    Article  CAS  Google Scholar 

  21. Bechrakis NE, Bornfeld N, Zoller I, et al. Iodine 125 plaque brachytherapy versus transscleral tumor resection in the treatment of large uveal melanomas. Ophthalmology. 2002;109(10):1855–61.

    Article  Google Scholar 

  22. Kivela T, Puusaari I, Damato B. Transscleral resection versus iodine brachytherapy for choroidal malignant melanomas 6 millimeters or more in thickness: a matched case-control study. Ophthalmology. 2003;110(11):2235–44.

    Article  Google Scholar 

  23. Damato BE, Paul J, Foulds WS. Risk factors for residual and recurrent uveal melanoma after trans-scleral local resection. Br J Ophthalmol. 1996;80(2):102–8.

    Article  CAS  Google Scholar 

  24. Kim JW, Damato BE, Hiscott P. Noncontiguous tumor recurrence of posterior uveal melanoma after transscleral local resection. Arch Ophthalmol. 2002;120(12):1659–64.

    Article  Google Scholar 

  25. Damato B. Adjunctive plaque radiotherapy after local resection of uveal melanoma. Front Radiat Ther Oncol. 1997;30:123–32.

    Article  CAS  Google Scholar 

  26. Damato B, Groenewald CP, McGalliard JN, et al. Rhegmatogenous retinal detachment after transscleral local resection of choroidal melanoma. Ophthalmology. 2002;109(11):2137–43.

    Article  Google Scholar 

  27. Damato BE, Paul J, Foulds WS. Risk factors for metastatic uveal melanoma after trans-scleral local resection. Br J Ophthalmol. 1996;80(2):109–16.

    Article  CAS  Google Scholar 

  28. Foulds WS, Damato BE, Burton RL. Local resection versus enucleation in the management of choroidal melanoma. Eye. 1987;1. ( Pt 6:676–9.

    Article  Google Scholar 

  29. Damato B. Choroidal melanoma endoresection, dandelions and allegory-based medicine. Br J Ophthalmol. 2008;92(8):1013–4.

    Article  Google Scholar 

  30. Hadden PW, Hiscott PS, Damato BE. Histopathology of eyes enucleated after endoresection of choroidal melanoma. Ophthalmology. 2004;111(1):154–60.

    Article  Google Scholar 

  31. Damato B, Wong D, Green FD, et al. Intrascleral recurrence of uveal melanoma after transretinal “endoresection”. Br J Ophthalmol. 2001;85(1):114–5.

    Article  CAS  Google Scholar 

  32. Bechrakis NE, Foerster MH. Neoadjuvant proton beam radiotherapy combined with subsequent endoresection of choroidal melanomas. Int Ophthalmol Clin. 2006;46(1):95–107.

    Article  Google Scholar 

  33. Rice JC, Liebenberg L, Scholtz RP, et al. Fatal air embolism during endoresection of choroidal melanoma. Retin Cases Brief Rep. 2014;8(2):127–9.

    Article  Google Scholar 

  34. Schalenbourg A, Coupland S, Kacperek A, et al. Iridocyclectomy for neovascular glaucoma caused by proton-beam radiotherapy of pigmented ciliary adenocarcinoma. Graefe’s Arch Clin Exp Ophthalmol = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 2008;246(10):1499–501.

    Article  Google Scholar 

  35. Damato EM, Damato B, Sibbring JS, et al. Ciliary body melanoma with partial deletion of chromosome 3 detected with multiplex ligation-dependent probe amplification. Graefe’s Arch Clin Exp Ophthalmol = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie. 2008;246(11):1637–40.

    Article  CAS  Google Scholar 

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Correspondence to Bertil E. Damato .

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Damato, B.E., Groenewald, C. (2019). Uveal Melanoma: Resection Techniques. In: Damato, B., Singh, A. (eds) Clinical Ophthalmic Oncology. Springer, Cham. https://doi.org/10.1007/978-3-030-17879-6_16

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  • DOI: https://doi.org/10.1007/978-3-030-17879-6_16

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-17878-9

  • Online ISBN: 978-3-030-17879-6

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