Abstract
The vascular system comprises large-, medium- and small-sized vessels, classified as arteries or veins. This system is extremely diverse in structure, architecture and physiology. The vascular wall is composed of three layers: intima, media and adventitia. The intima layer is mainly formed by a monolayer of endothelial cells, which are important to the regulation of vascular smooth cell relaxation and contraction by the production of endothelial-derived relaxing and constricting factors. The media layer is mostly composed by vascular smooth muscle cells that play a major role in changes of vascular diameter and maintenance of vascular tone. In the adventitia, the perivascular adipose tissue has been described as an important regulator of vascular function and inflammation. In this chapter, we will describe the phenotype of endothelial cells, vascular smooth muscle cells and perivascular adipose tissue, focusing on their role to maintain vascular tone and integrity in health and disease.
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References
Hoeben A, Landuyt B, Highley MS, Wildiers H, Van Oosterom AT, De Bruijn EA. Vascular endothelial growth factor and angiogenesis. Pharmacol Rev. 2004;56(4):549–80.
Chi JT, Chang HY, Haraldsen G, Jahnsen FL, Troyanskaya OG, Chang DS, et al. Endothelial cell diversity revealed by global expression profiling. Proc Natl Acad Sci U S A. 2003;100(19):10623–8.
Zhao Y, Vanhoutte PM, Leung SW. Vascular nitric oxide: beyond eNOS. J Pharmacol Sci. 2015;129(2):83–94.
Ozkor MA, Quyyumi AA. Endothelium-derived hyperpolarizing factor and vascular function. Cardiol Res Pract. 2011;2011:156146.
Goto K, Ohtsubo T, Kitazono T. Endothelium-Dependent Hyperpolarization (EDH) in hypertension: the role of endothelial ion channels. Int J Mol Sci. 2018;19(1):E315.
Kohan DE, Rossi NF, Inscho EW, Pollock DM. Regulation of blood pressure and salt homeostasis by endothelin. Physiol Rev. 2011;91(1):1–77.
Mehta D, Ravindran K, Kuebler WM. Novel regulators of endothelial barrier function. Am J Physiol Lung Cell Mol Physiol. 2014;307(12):L924–35.
Pober JS, Sessa WC. Evolving functions of endothelial cells in inflammation. Nat Rev Immunol. 2007;7(10):803–15.
Hilenski LL, Griendling KK. Vascular smooth muscle. Vascular medicine: a companion to Braunwald’s heart disease. 2nd ed. Philadelphia: WB Saunders; 2013. p. 25–42.
Owens GK, Kumar MS, Wamhoff BR. Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev. 2004;84(3):767–801.
Rensen SS, Doevendans PA, van Eys GJ. Regulation and characteristics of vascular smooth muscle cell phenotypic diversity. Neth Heart J. 2007;15(3):100–8.
Moiseeva EP. Adhesion receptors of vascular smooth muscle cells and their functions. Cardiovasc Res. 2001;52(3):372–86.
Rzucidlo EM. Signaling pathways regulating vascular smooth muscle cell differentiation. Vascular. 2009;17(Suppl 1):S15–20.
Hynes RO. The extracellular matrix: not just pretty fibrils. Science. 2009;326(5957):1216–9.
Touyz RM, Alves-Lopes R, Rios FJ, Camargo LL, Anagnostopoulou A, Arner A, Montezano AC. Vascular smooth muscle contraction in hypertension. Cardiovasc Res. 2018;114(4):529–39.
Lian X, Gollasch M. A clinical perspective: contribution of dysfunctional perivascular adipose tissue (PVAT) to cardiovascular risk. Curr Hypertens Rep. 2016;18(11):82.
Costa RM, Neves KB, Tostes RC, Lobato NS. Perivascular adipose tissue as a relevant fat depot for cardiovascular risk in obesity. Front Physiol. 2018;9:253.
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Alves-Lopes, R., Touyz, R.M., Montezano, A.C. (2019). Cell Biology of Vessels. In: Touyz, R., Delles, C. (eds) Textbook of Vascular Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-16481-2_3
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DOI: https://doi.org/10.1007/978-3-030-16481-2_3
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