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Microparticles and Exosomes in Cell-Cell Communication

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Textbook of Vascular Medicine

Abstract

Growing evidence indicates that cells are able to communicate with neighbouring and distant cells in the body by production of extracellular vesicles (EV). EV are classified according to their size and mechanisms of formation. Exosomes and microparticles are the most extensively studied clinically relevant forms of EV, and they often reflect the activation status of the parent cell, by carrying similar surface markers and cargo. Because of these molecular characteristics, EV are considered to be mediators of cell activation by transferring molecules (e.g., proteins, lipids, and nucleic acids) to neighbouring or distant cell populations. Increased levels of circulating EV have been observed in various diseases, including hypertension, atherosclerosis, kidney diseases, and cancer. In this chapter, we will address the formation of different EV and their importance in cell-cell communication, controlling basic cellular functions in homeostatic and pathologic conditions associated with cardiovascular diseases. In addition, we highlight their role as biomarkers and discuss the potential of EV as therapeutic tools.

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Author information

Authors and Affiliations

  1. Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK

    Francisco J. Rios, Rhian M. Touyz & Augusto C. Montezano

  2. Kidney Research Centre, Ottawa Hospital Research Institute, University of Ottawa, Ottawa, ON, Canada

    Dylan Burger

Authors
  1. Francisco J. Rios
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  2. Rhian M. Touyz
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  3. Augusto C. Montezano
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  4. Dylan Burger
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Corresponding author

Correspondence to Francisco J. Rios .

Editor information

Editors and Affiliations

  1. Institute of Cardiovascular and Medical Science, University of Glasgow, Glasgow, UK

    Rhian M. Touyz

  2. Institute of Cardiovascular and Medical Science, University of Glasgow, Glasgow, UK

    Christian Delles

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Rios, F.J., Touyz, R.M., Montezano, A.C., Burger, D. (2019). Microparticles and Exosomes in Cell-Cell Communication. In: Touyz, R., Delles, C. (eds) Textbook of Vascular Medicine. Springer, Cham. https://doi.org/10.1007/978-3-030-16481-2_15

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  • DOI: https://doi.org/10.1007/978-3-030-16481-2_15

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-16480-5

  • Online ISBN: 978-3-030-16481-2

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