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Mild Blast-Induced Traumatic Brain Injury Model

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Animal Models of Acute Neurological Injury

Part of the book series: Springer Series in Translational Stroke Research ((SSTSR))

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Abstract

Blast injuries from explosive events can be simulated in a laboratory setting through a variety of means. Different elements of blast-induced traumatic brain injuries can be recapitulated in the laboratory setting in tandem or in isolation to investigate a variety of research questions. The research question of interest will dictate choices regarding the modality of blast generation, animal positioning, head fixation, and body protection. Due to the relatively young nature of the field and the various blast injury models, consensus opinions have not been reached with regard to model designs, exposure conditions, and outcome evaluations. This chapter outlines one procedure for administering a diffuse, closed-head mild blast-induced TBI (mild bTBI) to rats via open-ended shock tube and includes discussion on the impact of differing choices with regard to model design, exposure conditions, and outcome evaluations.

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Author information

Authors and Affiliations

  1. College of Veterinary Medicine, Department of Basic Medical Sciences, Purdue University, Indianapolis, IN, USA

    Riyi Shi

  2. Weldon School of Biomedical Engineering, Purdue University, Indianapolis, IN, USA

    Riyi Shi & Nicholas Race

  3. School of Medicine, Indiana University, Indianapolis, IN, USA

    Nicholas Race

Authors
  1. Riyi Shi
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  2. Nicholas Race
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Corresponding author

Correspondence to Riyi Shi .

Editor information

Editors and Affiliations

  1. Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

    Jun Chen

  2. Department of Anatomy and Cell Biology, Indiana University School of Medicine, Indianapolis, IN, USA

    Zao C. Xu

  3. Indiana University School of Medicine, SNRI SCBIRG, Indianapolis, IN, USA

    Xiao Ming Xu

  4. Center for Neuroscience Research, Loma Linda University School of Medicine, Loma Linda, CA, USA

    John H. Zhang

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Shi, R., Race, N. (2019). Mild Blast-Induced Traumatic Brain Injury Model. In: Chen, J., Xu, Z., Xu, X., Zhang, J. (eds) Animal Models of Acute Neurological Injury. Springer Series in Translational Stroke Research. Springer, Cham. https://doi.org/10.1007/978-3-030-16082-1_27

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  • DOI: https://doi.org/10.1007/978-3-030-16082-1_27

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-16080-7

  • Online ISBN: 978-3-030-16082-1

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