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Introduction

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Nutrition and Immunity

Abstract

Having a variety of cells, organs, and mechanisms, the immune system is able to produce pleiotropic effects that are truly tangible throughout the body. Recently, the possibility of training the overall immunity has been sublated into literature. As a result, there is now pressure to explore factors affecting the immune system, more than before. Heritable and nonheritable factors interact to determine the immune health. In particular, study of healthy twins pointed to the substantial share that nonheritable factors, including nutritional factors, have in establishing immunological parameters. This chapter shows the basic ideas behind the book Nutrition and Immunity.

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References

  1. Janeway CA, Travers P, Walport M, Shlomchik MJ. Immunobiology: the immune system in health and disease. New York: Garland Science; 2005.

    Google Scholar 

  2. Akira S, Uematsu S, Takeuchi O. Pathogen recognition and innate immunity. Cell. 2006;124(4):783–801.

    Article  CAS  PubMed  Google Scholar 

  3. Janeway CA Jr, Medzhitov R. Innate immune recognition. Annu Rev Immunol. 2002;20(1):197–216.

    Article  CAS  PubMed  Google Scholar 

  4. Medzhitov R, Janeway CA. Innate immunity: the virtues of a nonclonal system of recognition. Cell. 1997;91(3):295–8.

    Article  CAS  PubMed  Google Scholar 

  5. Müller N, Ackenheil M. Psychoneuroimmunology and the cytokine action in the CNS: implications for psychiatric disorders. Prog Neuro-Psychopharmacol Biol Psychiatry. 1998;22(1):1–33.

    Article  Google Scholar 

  6. Grivennikov SI, Greten FR, Karin M. Immunity, inflammation, and cancer. Cell. 2010;140(6):883–99.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Heneka MT, Kummer MP, Latz E. Innate immune activation in neurodegenerative disease. Nat Rev Immunol. 2014;14(7):463.

    Article  CAS  PubMed  Google Scholar 

  8. Netea MG, Joosten LAB, Latz E, Mills KHG, Natoli G, Stunnenberg HG, et al. Trained immunity: a program of innate immune memory in health and disease. Science (New York, NY). 2016;352(6284):aaf1098–aaf.

    Article  CAS  Google Scholar 

  9. Netea MG. Training innate immunity: the changing concept of immunological memory in innate host defence. Eur J Clin Investig. 2013;43(8):881–4.

    Article  CAS  Google Scholar 

  10. Brodin P, Jojic V, Gao T, Bhattacharya S, Angel Cesar JL, Furman D, et al. Variation in the human immune system is largely driven by non-heritable influences. Cell. 2015;160(1):37–47.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Hotamisligil GS. Inflammation, metaflammation and immunometabolic disorders. Nature. 2017;542(7640):177.

    Article  CAS  PubMed  Google Scholar 

  12. Calder PC, Jackson AA. Undernutrition, infection and immune function. Nutr Res Rev. 2000;13(1):3–29.

    Article  CAS  PubMed  Google Scholar 

  13. Mathis D, Shoelson SE. Immunometabolism: an emerging frontier. Nat Rev Immunol. 2011;11(2):81.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. O’Neill LAJ, Kishton RJ, Rathmell J. A guide to immunometabolism for immunologists. Nat Rev Immunol. 2016;16(9):553.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  15. Hirosumi J, Tuncman G, Chang L, Görgün CZ, Uysal KT, Maeda K, et al. A central role for JNK in obesity and insulin resistance. Nature. 2002;420(6913):333.

    Article  CAS  PubMed  Google Scholar 

  16. Kawamori D, Kaneto H, Nakatani Y, Matsuoka T-a, Matsuhisa M, Hori M, et al. The forkhead transcription factor Foxo1 bridges the JNK pathway and the transcription factor PDX-1 through its intracellular translocation. J Biol Chem. 2006;281(2):1091–8.

    Article  CAS  PubMed  Google Scholar 

  17. Cross DAE, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature. 1995;378(6559):785.

    Article  CAS  PubMed  Google Scholar 

  18. Kops GJPL, Dansen TB, Polderman PE, Saarloos I, Wirtz KWA, Coffer PJ, et al. Forkhead transcription factor FOXO3a protects quiescent cells from oxidative stress. Nature. 2002;419(6904):316.

    Article  CAS  PubMed  Google Scholar 

  19. Marchetti V, Menghini R, Rizza S, Vivanti A, Feccia T, Lauro D, et al. Benfotiamine counteracts glucose toxicity effects on endothelial progenitor cell differentiation via Akt/FoxO signaling. Diabetes. 2006;55(8):2231–7.

    Article  CAS  PubMed  Google Scholar 

  20. Cohen P, Frame S. The renaissance of GSK3. Nat Rev Mol Cell Biol. 2001;2(10):769.

    Article  CAS  PubMed  Google Scholar 

  21. Jope RS, Yuskaitis CJ, Beurel E. Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics. Neurochem Res. 2007;32(4–5):577–95.

    Article  CAS  PubMed  Google Scholar 

  22. Aguirre V, Uchida T, Yenush L, Davis R, White MF. The c-Jun NH2-terminal kinase promotes insulin resistance during association with insulin receptor substrate-1 and phosphorylation of Ser307. J Biol Chem. 2000;275(12):9047–54.

    Article  CAS  PubMed  Google Scholar 

  23. Gibson GR, Roberfroid MB. Dietary modulation of the human colonic microbiota: introducing the concept of prebiotics. J Nutr. 1995;125(6):1401–12.

    Article  CAS  PubMed  Google Scholar 

  24. Lee YK, Mazmanian SK. Has the microbiota played a critical role in the evolution of the adaptive immune system? Science. 2010;330(6012):1768–73.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Wen L, Ley RE, Volchkov PY, Stranges PB, Avanesyan L, Stonebraker AC, et al. Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature. 2008;455(7216):1109.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Clarke TB, Davis KM, Lysenko ES, Zhou AY, Yu Y, Weiser JN. Recognition of peptidoglycan from the microbiota by Nod1 enhances systemic innate immunity. Nat Med. 2010;16(2):228.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Mazmanian SK, Liu CH, Tzianabos AO, Kasper DL. An immunomodulatory molecule of symbiotic bacteria directs maturation of the host immune system. Cell. 2005;122(1):107–18.

    Article  CAS  PubMed  Google Scholar 

  28. Pearson CI, McDevitt HO. Redirecting Th1 and Th2 responses in autoimmune disease. Curr Top Microbiol Immunol. 1999;238:79–122.

    CAS  PubMed  Google Scholar 

  29. Lee YK, Menezes JS, Umesaki Y, Mazmanian SK. Proinflammatory T-cell responses to gut microbiota promote experimental autoimmune encephalomyelitis. Proc Natl Acad Sci. 2011;108(Suppl 1):4615–22.

    Article  CAS  PubMed  Google Scholar 

  30. Wu H-J, Ivanov II, Darce J, Hattori K, Shima T, Umesaki Y, et al. Gut-residing segmented filamentous bacteria drive autoimmune arthritis via T helper 17 cells. Immunity. 2010;32(6):815–27.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Marcos A, Nova E, Montero A. Changes in the immune system are conditioned by nutrition. Eur J Clin Nutr. 2003;57(S1):S66.

    Article  CAS  PubMed  Google Scholar 

  32. Kjer-Nielsen L, Patel O, Corbett AJ, Le Nours J, Meehan B, Liu L, et al. MR1 presents microbial vitamin B metabolites to MAIT cells. Nature. 2012;491(7426):717–23.

    Article  CAS  PubMed  Google Scholar 

  33. Semba RD, Vitamin A. Immunity, and infection. Clin Infect Dis. 1994;19(3):489–99.

    Article  CAS  PubMed  Google Scholar 

  34. Bendich A. Carotenoids and the immune response. J Nutr. 1989;119(1):112–5.

    Article  CAS  PubMed  Google Scholar 

  35. Ross AC. Vitamin A status: relationship to immunity and the antibody response. Proc Soc Exp Biol Med. 1992;200(3):303–20.

    Article  CAS  PubMed  Google Scholar 

  36. Semba RD, Chiphangwi JD, Miotti PG, Dallabetta GA, Hoover DR, Canner JK, et al. Maternal vitamin A deficiency and mother-to-child transmission of HIV-1. Lancet. 1994;343(8913):1593–7.

    Article  CAS  PubMed  Google Scholar 

  37. Kunisawa J, Kiyono H. Vitamin-mediated regulation of intestinal immunity. Front Immunol. 2013;4:189.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  38. Iwata M, Hirakiyama A, Eshima Y, Kagechika H, Kato C, Song S-Y. Retinoic acid imprints gut-homing specificity on T cells. Immunity. 2004;21(4):527–38.

    Article  CAS  PubMed  Google Scholar 

  39. Mora JR, Iwata M, Eksteen B, Song S-Y, Junt T, Senman B, et al. Generation of gut-homing IgA-secreting B cells by intestinal dendritic cells. Science. 2006;314(5802):1157.

    Article  CAS  PubMed  Google Scholar 

  40. Villamor E, Fawzi WW. Effects of vitamin A supplementation on immune responses and correlation with clinical outcomes. Clin Microbiol Rev. 2005;18(3):446.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Spinas E, Saggini A, Kritas SK, Cerulli G, Caraffa A, Antinolfi P, et al. Crosstalk between vitamin B and immunity. J Biol Regul Homeost Agents. 2015;29(2):283–8.

    CAS  PubMed  Google Scholar 

  42. Kunisawa J. Metabolic changes during B cell differentiation for the production of intestinal IgA antibody. Cell Mol Life Sci. 2017;74(8):1503–9.

    Article  CAS  PubMed  Google Scholar 

  43. Hu S, He W, Du X, Huang Y, Fu Y, Yang Y, et al. Vitamin B1 helps to limit Mycobacterium tuberculosis growth via regulating innate immunity in a peroxisome proliferator-activated receptor-gamma-dependent manner. Front Immunol. 2018;9:1778.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  44. Kunisawa J, Sugiura Y, Wake T, Nagatake T, Suzuki H, Nagasawa R, et al. Mode of bioenergetic metabolism during B cell differentiation in the intestine determines the distinct requirement for vitamin B1. Cell Rep. 2015;13(1):122–31.

    Article  CAS  PubMed  Google Scholar 

  45. Ahn I-P, Kim S, Lee Y-H. Vitamin B1 functions as an activator of plant disease resistance. Plant Physiol. 2005;138(3):1505–15.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  46. Le Bourhis L, Martin E, Peguillet I, Guihot A, Froux N, Core M, et al. Antimicrobial activity of mucosal-associated invariant T cells. Nat Immunol. 2010;11(8):701–8.

    Article  PubMed  CAS  Google Scholar 

  47. Young MH, Gapin L. Mucosal associated invariant T cells: don’t forget your vitamins. Cell Res. 2013;23(4):460–2.

    Article  CAS  PubMed  Google Scholar 

  48. Le Bourhis L, Mburu YK, Lantz O. MAIT cells, surveyors of a new class of antigen: development and functions. Curr Opin Immunol. 2013;25(2):174–80.

    Article  PubMed  CAS  Google Scholar 

  49. Chen L, Feng L, Jiang W-D, Jiang J, Wu P, Zhao J, et al. Dietary riboflavin deficiency decreases immunity and antioxidant capacity, and changes tight junction proteins and related signaling molecules mRNA expression in the gills of young grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2015;45(2):307–20.

    Article  CAS  PubMed  Google Scholar 

  50. Araki S, Suzuki M, Fujimoto M, Kimura M. Enhancement of resistance to bacterial infection in mice by vitamin B2. J Vet Med Sci. 1995;57(4):599–602.

    Article  CAS  PubMed  Google Scholar 

  51. Schramm M, Wiegmann K, Schramm S, Gluschko A, Herb M, Utermohlen O, et al. Riboflavin (vitamin B2) deficiency impairs NADPH oxidase 2 (Nox2) priming and defense against Listeria monocytogenes. Eur J Immunol. 2014;44(3):728–41.

    Article  CAS  PubMed  Google Scholar 

  52. Singh N, Gurav A, Sivaprakasam S, Brady E, Padia R, Shi H, et al. Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis. Immunity. 2014;40(1):128–39.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  53. Kamanna VS, Kashyap ML. Mechanism of action of niacin. Am J Cardiol. 2008;101(8):S20–S6.

    Article  CAS  Google Scholar 

  54. Stephenson M, Rowatt E, Harrison K. The production of acetylcholine by a strain of Lactobacillus plantarum. Microbiology. 1947;1(3):279–98.

    CAS  Google Scholar 

  55. Rowatt E. The relation of pantothenic acid to acetylcholine formation by a strain of Lactobacillus plantarum. Microbiology. 1948;2(1):25–30.

    CAS  Google Scholar 

  56. Rivera-Calimlim L, Hartley D, Osterhout D. Effects of ethanol and pantothenic acid on brain acetylcholine synthesis. Br J Pharmacol. 1988;95(1):77–82.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. Gominak SC. Vitamin D deficiency changes the intestinal microbiome reducing B vitamin production in the gut. The resulting lack of pantothenic acid adversely affects the immune system, producing a “pro-inflammatory” state associated with atherosclerosis and autoimmunity. Med Hypotheses. 2016;94:103–7.

    Article  CAS  PubMed  Google Scholar 

  58. Li L, Feng L, Jiang W-D, Jiang J, Wu P, Kuang S-Y, et al. Dietary pantothenic acid deficiency and excess depress the growth, intestinal mucosal immune and physical functions by regulating NF-κB, TOR, Nrf2 and MLCK signaling pathways in grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2015;45(2):399–413.

    Article  CAS  PubMed  Google Scholar 

  59. Meydani SN, Ribaya-Mercado JD, Russell RM, Sahyoun N, Morrow FD, Gershoff SN. Vitamin B− 6 deficiency impairs interleukin 2 production and lymphocyte proliferation in elderly adults. Am J Clin Nutr. 1991;53(5):1275–80.

    Article  CAS  PubMed  Google Scholar 

  60. Cheng CH, Chang SJ, Lee BJ, Lin KL, Huang YC. Vitamin B 6 supplementation increases immune responses in critically ill patients. Eur J Clin Nutr. 2006;60(10):1207.

    Article  CAS  PubMed  Google Scholar 

  61. Folkers K, Morita M, McRee J. The activities of coenzyme Q10 and vitamin B6 for immune responses. Biochem Biophys Res Commun. 1993;193(1):88–92.

    Article  CAS  PubMed  Google Scholar 

  62. Kunisawa J, Hashimoto E, Ishikawa I, Kiyono H. A pivotal role of vitamin B9 in the maintenance of regulatory T cells in vitro and in vivo. PLoS One. 2012;7(2):e32094.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  63. Kinoshita M, Kayama H, Kusu T, Yamaguchi T, Kunisawa J, Kiyono H, et al. Dietary folic acid promotes survival of Foxp3+ regulatory T cells in the colon. J Immunol. 2012;189(6):2869–78.

    Article  CAS  PubMed  Google Scholar 

  64. Courtemanche C, Elson-Schwab I, Mashiyama ST, Kerry N, Ames BN. Folate deficiency inhibits the proliferation of primary human CD8+ T lymphocytes in vitro. J Immunol (Baltimore: 1950). 2004;173(5):3186–92.

    CAS  Google Scholar 

  65. Tamura J, Kubota K, Murakami H, Sawamura M, Matsushima T, Tamura T, et al. Immunomodulation by vitamin B12: augmentation of CD8+ T lymphocytes and natural killer (NK) cell activity in vitamin B12-deficient patients by methyl-B12 treatment. Clin Exp Immunol. 1999;116(1):28–32.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  66. Tewary A, Patra BC. Use of vitamin C as an immunostimulant. Effect on growth, nutritional quality, and immune response of Labeo rohita (Ham.). Fish Physiol Biochem. 2008;34(3):251–9.

    Article  CAS  PubMed  Google Scholar 

  67. Kennes B, Dumont I, Brohee D, Hubert C, Neve P. Effect of vitamin C supplements on cell-mediated immunity in old people. Gerontology. 1983;29(5):305–10.

    Article  CAS  PubMed  Google Scholar 

  68. Härtel C, Strunk T, Bucsky P, Schultz C. Effects of vitamin C on intracytoplasmic cytokine production in human whole blood monocytes and lymphocytes. Cytokine. 2004;27(4–5):101–6.

    Article  PubMed  CAS  Google Scholar 

  69. Waagbø R, Glette J, Raa-Nilsen E, Sandnes K. Dietary vitamin C, immunity and disease resistance in Atlantic salmon (Salmo salar). Fish Physiol Biochem. 1993;12(1):61–73.

    Article  PubMed  Google Scholar 

  70. Wintergerst ES, Maggini S, Hornig DH. Immune-enhancing role of vitamin C and zinc and effect on clinical conditions. Ann Nutr Metab. 2006;50(2):85–94.

    Article  CAS  PubMed  Google Scholar 

  71. Adams JS, Hewison M. Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity. Nat Rev Endocrinol. 2008;4(2):80.

    Article  CAS  Google Scholar 

  72. Pludowski P, Holick MF, Pilz S, Wagner CL, Hollis BW, Grant WB, et al. Vitamin D effects on musculoskeletal health, immunity, autoimmunity, cardiovascular disease, cancer, fertility, pregnancy, dementia and mortality—a review of recent evidence. Autoimmun Rev. 2013;12(10):976–89.

    Article  CAS  PubMed  Google Scholar 

  73. Cutolo M, Otsa K. Review: vitamin D, immunity and lupus. Lupus. 2008;17(1):6–10.

    Article  CAS  PubMed  Google Scholar 

  74. Martineau AR, Wilkinson RJ, Wilkinson KA, Newton SM, Kampmann B, Hall BM, et al. A single dose of vitamin D enhances immunity to mycobacteria. Am J Respir Crit Care Med. 2007;176(2):208–13.

    Article  CAS  PubMed  Google Scholar 

  75. Palacios C, Gonzalez L. Is vitamin D deficiency a major global public health problem? J Steroid Biochem Mol Biol. 2014;144:138–45.

    Article  CAS  PubMed  Google Scholar 

  76. Cashman KD, Dowling KG, Škrabáková Z, Gonzalez-Gross M, Valtueña J, De Henauw S, et al. Vitamin D deficiency in Europe: pandemic? Am J Clin Nutr. 2016;103(4):1033–44.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  77. Moriguchi S, Muraga M. Vitamin E and immunity. Vitam Horm. 2000;59:305–36.

    Article  CAS  PubMed  Google Scholar 

  78. Meydani SN, Barklund MP, Liu S, Meydani M, Miller RA, Cannon JG, et al. Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects. Am J Clin Nutr. 1990;52(3):557–63.

    Article  CAS  PubMed  Google Scholar 

  79. Pallast EG, Schouten EG, de Waart FG, Fonk HC, Doekes G, von Blomberg BM, et al. Effect of 50- and 100-mg vitamin E supplements on cellular immune function in noninstitutionalized elderly persons. Am J Clin Nutr. 1999;69(6):1273–81.

    Article  CAS  PubMed  Google Scholar 

  80. Meydani SN, Meydani M, Verdon CP, Shapiro AA, Blumberg JB, Hayes KC. Vitamin E supplementation suppresses prostaglandin E21 synthesis and enhances the immune response of aged mice. Mech Ageing Dev. 1986;34(2):191–201.

    Article  CAS  PubMed  Google Scholar 

  81. Tengerdy RP, Brown JC. Effect of vitamin E and A on humoral immunity and phagocytosis in E. coli infected chicken. Poult Sci. 1977;56(3):957–63.

    Article  CAS  PubMed  Google Scholar 

  82. Gore AB, Qureshi MA. Enhancement of humoral and cellular immunity by vitamin E after embryonic exposure. Poult Sci. 1997;76(7):984–91.

    Article  CAS  PubMed  Google Scholar 

  83. Chavance M, Herbeth B, Fournier C, Janot C, Vernhes G. Vitamin status, immunity and infections in an elderly population. Eur J Clin Nutr. 1989;43(12):827–35.

    CAS  PubMed  Google Scholar 

  84. Meydani S, Meydani M, Blumberg JB, et al. Vitamin e supplementation and in vivo immune response in healthy elderly subjects: a randomized controlled trial. JAMA. 1997;277(17):1380–6.

    Article  CAS  PubMed  Google Scholar 

  85. Nockels CF, editor. Protective effects of supplemental vitamin E against infection. Vitamin E supplementation. Fed Proc. 1979;38(7):2134–8.

    Google Scholar 

  86. Odeleye OE, Watson RR. The potential role of vitamin E in the treatment of immunologic abnormalities during acquired immune deficiency syndrome. Prog Food Nutr Sci. 1991;15(1–2):1–19.

    CAS  PubMed  Google Scholar 

  87. Arthur JR, McKenzie RC, Beckett GJ. Selenium in the immune system. J Nutr. 2003;133(5):1457S–9S.

    Article  CAS  PubMed  Google Scholar 

  88. Chang CCC, Ślesak I, Jordá L, Sotnikov A, Melzer M, Miszalski Z, et al. Arabidopsis chloroplastic glutathione peroxidases play a role in cross talk between photooxidative stress and immune responses. Plant Physiol. 2009;150(2):670.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  89. Kehl-Fie TE, Skaar EP. Nutritional immunity beyond iron: a role for manganese and zinc. Curr Opin Chem Biol. 2010;14(2):218–24.

    Article  CAS  PubMed  Google Scholar 

  90. Rink L, Haase H. Zinc homeostasis and immunity. Trends Immunol. 2007;28(1):1–4.

    Article  CAS  PubMed  Google Scholar 

  91. Prasad AS. Zinc: role in immunity, oxidative stress and chronic inflammation. Curr Opin Clin Nutr Metab Care. 2009;12(6):646–52.

    Article  CAS  PubMed  Google Scholar 

  92. Ogden CL, Carroll MD, Kit BK, Flegal KM. Prevalence of childhood and adult obesity in the United States, 2011–2012. JAMA. 2014;311(8):806–14.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  93. Ogden CL, Carroll MD, Fryar CD, Flegal KM. Prevalence of obesity among adults and youth: United States, 2011–2014. US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Health Statistics, Washington, D.C.; 2015.

    Google Scholar 

  94. Osborn O, Olefsky JM. The cellular and signaling networks linking the immune system and metabolism in disease. Nat Med. 2012;18(3):363.

    Article  CAS  PubMed  Google Scholar 

  95. Valdés-Ramos R, Benitez-Arciniega AD. Nutrition and immunity in cancer. Br J Nutr. 2007;98(S1):S127–S32.

    Article  PubMed  CAS  Google Scholar 

  96. Wärnberg J, Gomez-Martinez S, Romeo J, Díaz LE, Marcos A. Nutrition, inflammation, and cognitive function. Ann N Y Acad Sci. 2009;1153(1):164–75.

    Article  PubMed  CAS  Google Scholar 

  97. DeLegge MH, Smoke A. Neurodegeneration and inflammation. Nutr Clin Pract. 2008;23(1):35–41.

    Article  PubMed  Google Scholar 

  98. Vir SC, Love AHG. Nutritional status of institutionalized and noninstitutionalized aged in Belfast, Northern Ireland. Am J Clin Nutr. 1979;32(9):1934–47.

    Article  CAS  PubMed  Google Scholar 

  99. Gillette-Guyonnet S, Secher M, Vellas B. Nutrition and neurodegeneration: epidemiological evidence and challenges for future research. Br J Clin Pharmacol. 2013;75(3):738–55.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  100. Meydani M. Nutrition interventions in aging and age-associated disease. Ann N Y Acad Sci. 2001;928(1):226–35.

    Article  CAS  PubMed  Google Scholar 

  101. Macia L, Thorburn AN, Binge LC, Marino E, Rogers KE, Maslowski KM, et al. Microbial influences on epithelial integrity and immune function as a basis for inflammatory diseases. Immunol Rev. 2011;245(1):164–76.

    Article  Google Scholar 

  102. Müller M, Kersten S. Nutrigenomics: goals and strategies. Nat Rev Genet. 2003;4(4):315.

    Article  PubMed  CAS  Google Scholar 

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Saghazadeh, A., Mahmoudi, M., Rezaei, N. (2019). Introduction. In: Mahmoudi, M., Rezaei, N. (eds) Nutrition and Immunity. Springer, Cham. https://doi.org/10.1007/978-3-030-16073-9_1

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