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Central and Peripheral Nervous Disorders

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Health and Gender

Abstract

There is increasing attention on determinants of health including not only the genetic and biological differences between males and females defining what we usually call “sex” but also psychological, environmental, and sociocultural factors that define what is commonly called “gender” and which may affect disproportionally men’s and women’s health.

“Dimorphic neurology” focuses on differences between men and women in the causes, manifestations, response to treatments, and outcomes of neurological diseases.

In these pages the authors focus on the implications of sex, gender, and some of the most frequent neurologic diseases, such as stroke, dementia, epilepsy, migraine, and multiple sclerosis.

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References

  1. Rocca WA, Mielke MM, Vemuri P, Miller VM. Sex and gender differences in the causes of dementia: a narrative review. Maturitas. 2014;79(2):196–201.

    Article  PubMed  PubMed Central  Google Scholar 

  2. US Public Health Service. Agenda for research on women’s health for the 21st century. A report of the Task Force on the NIH Women’s Health Research Agenda for the 21st Century, vol. 5. Bethesda, MD: National Institutes of Health; 1999. (DHHS publication no. (NIH) 99-4389).

    Google Scholar 

  3. Institute of Medicine. Women’s health research: progress, pitfalls, and promise. Washington, DC: The National Academies Press; 2010.

    Google Scholar 

  4. Woods NF, Tsui AO. Editorial: Epidemiologic approaches to women’s health. Epidemiol Rev. 2014;36:1–4.

    Article  PubMed  Google Scholar 

  5. Ahnstedt H, McCullough LD, Cipolla MJ. The importance of considering sex differences in translational stroke research. Transl Stroke Res. 2016;7(4):261–73.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Shekhar S, Travis OK, He X, Roman RJ, Fan F. Menopause and ischemic stroke: a brief review. MOJ Toxicol. 2017;3(4) https://doi.org/10.15406/mojt.2017.03.00059.

  7. SPREAD. (Stroke Prevention And Educational Awareness Diffusion) - Ictus cerebrale: linee guida italiane di prevenzione e trattamento - VIII Edizione.

    Google Scholar 

  8. Bushnell C, McCullough LD, Awad IA, Chireau MV, Fedder WN, Furie KL, Howard VJ, Lichtman JH, Lisabeth LD, Piña IL, Reeves MJ, Rexrode KM, Saposnik G, Singh V, Towfighi A, Vaccarino V, Walters MR, on behalf of the American Heart Association Stroke Council, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, Council on Epidemiology and Prevention, and Council for High Blood Pressure Research. Guidelines for the prevention of stroke in women. A statement for healthcare professionals from the American Heart Association/American Stroke Association. Stroke. 2014;45:1545–88.

    Article  PubMed  Google Scholar 

  9. Samai AA, Martin-Schild S. Sex differences in predictors of ischemic stroke: current perspectives. Vasc Health Risk Manag. 2015;11:427–36.

    PubMed  PubMed Central  Google Scholar 

  10. Gryglas A, Smigiel R. Migraine and stroke: What’s the link? What to do? Curr Neurol Neurosci Rep. 2017;17:22.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Kurth T, Winter AC, Eliassen AH, Dushkes R, Mukamal KJ, Rimm EB, Willett WC, Manson JE, Rexrode KM. Migraine and risk of cardiovascular disease in women: prospective cohort study. BMJ. 2016;353:i2610.

    Article  PubMed  PubMed Central  Google Scholar 

  12. Reeves MJ, Bushnell CD, Howard G, Gargano JW, Duncan PW, Lynch G, Khatiwoda A, Lisabeth L. Sex differences in stroke: epidemiology, clinical presentation, medical care, and outcomes. Lancet Neurol. 2008;7(10):915–26.

    Article  PubMed  PubMed Central  Google Scholar 

  13. Boheme AK, Carr BG, Kasner SE, Albright KC, Kallan MJ, Elkind MSV, Branas CC, Mullen MT. Sex differences in rt-PA utilization at hospitals treating stroke: the national inpatient sample. Front Neurol. 2017;8:500. https://doi.org/10.3389/fneur.2017.00500.

    Article  Google Scholar 

  14. Berglund A, Schenk-Gustafsson K, von Euler M. Sex differences in the presentation of stroke. Maturitas. 2017;99:47–50.

    Article  CAS  PubMed  Google Scholar 

  15. Kim TD, Jung YH, Caso V, Bushnell CD, Saposnik G, on behalf of the Women’s Disparities Working Group. Countries with women inequalities have higher stroke mortality. Int J Stroke. 2017;12(8):869–74.

    Article  PubMed  Google Scholar 

  16. Livingston G, Sommerlad A, Orgeta V, Costafreda SG, Huntley J, Ames D, Ballard C, Banerjee S, Burns A, Cohen-Mansfield J, Cooper C, Fox N, Gitlin LN, Howard R, Kales HC, Larson EB, Ritchie K, Rockwood K, Sampson EL, Samus Q, Schneider LS, Selbæk G, Teri L, Mukadam N. Dementia prevention, intervention and care. Lancet. 2017;390(10113):2673–734.

    Article  PubMed  Google Scholar 

  17. Bannett D. Public health importance of vascular dementia and Alzheimer’s disease with cerebrovascular disease. Int J Clin Pract Suppl. 2001;(120):41–8.

    Google Scholar 

  18. Rizzi L, Rosset I, Roriz-Cruz M. Global epidemiology of dementia: Alzheimer’s and vascular types. BioMed Res Int. 2014;2014:908915, 8 pages.

    Article  Google Scholar 

  19. Mielke MM, Vemuri P, Rocca WA. Clinical epidemiology of Alzheimer’s disease: assessing sex and gender differences. Clin Epidemiol. 2014;6:37–48.

    Article  PubMed  PubMed Central  Google Scholar 

  20. Stern Y. Cognitive reserve. Neuropsychologia. 2009;47(10):2015–28.

    Article  PubMed  PubMed Central  Google Scholar 

  21. Headache Classification Committee of the International Headache Society. The international classification of headache disorders, 3rd edition (beta version). Cephalalgia. 2013;33(9):629–808.

    Article  Google Scholar 

  22. IHME. Global burden of disease study 2015 (GBD 2015). Seattle, WA: Institute for Health Metrics and Evaluation; 2016.

    Google Scholar 

  23. Victor TW, Hu X, Campbell JC, Buse DC, Lipton RB. Migraine prevalence by age and sex in the United States: a life-span study. Cephalalgia. 2010;30:1065–72.

    Article  CAS  PubMed  Google Scholar 

  24. Russell MB, Rasmussen BK, Thorvaldsen P, Olesen J. Prevalence and sex-ratio of the subtypes of migraine. Int J Epidemiol. 1995;24:612–8.

    Article  CAS  PubMed  Google Scholar 

  25. Vetvik KG, MacGregor EA. Sex differences in the epidemiology, clinical features, and pathophysiology of migraine. Lancet Neurol. 2017;16(1):76–87.

    Article  CAS  PubMed  Google Scholar 

  26. Granella F, Sances G, Allais G, Nappi RE, Tirelli A, Benedetto C, Brundu B, Facchinetti F, Nappi G. Characteristics of menstrual and nonmenstrual attacks in women with menstrually related migraine referred to headache centres. Cephalalgia. 2004;24(9):707–16.

    Article  CAS  PubMed  Google Scholar 

  27. WHO. Medical eligibility criteria for contraceptive use. 5th ed. Geneva: World Health Organization; 2015.

    Google Scholar 

  28. Ripa P, Ornello R, Degan D, Tiseo C, Stewart J, Pistoia F, Carolei A, Sacco S. Migraine in menopausal women: a systematic review. Int J Womens Health. 2015;7:773–82.

    PubMed  PubMed Central  Google Scholar 

  29. Maasumi K, Tepper SJ, Kriegler JS. Menstrual migraine and treatment options: review. Headache. 2017;57(2):194–208.

    Article  PubMed  Google Scholar 

  30. Allais GB, Rolando S, Benedetto C. La donna emicranica. In: Bonavita V, Bussone G, Casucci G, Frediani F, Manzoni GC, editors. Le Cefalee- Clinica e Terapia. Milano, Italy: Cortina Editore, press; 2015.

    Google Scholar 

  31. Segal BM, Cohen JA, Antel J. Americas Committee for Treatment and Research in Multiple Sclerosis Forum 2017: Environmental factors, genetics, and epigenetics in MS susceptibility and clinical course. Mult Scler J. 2018;24(1):4–5.

    Article  Google Scholar 

  32. Canto E, Oksenberg JR. Multiple sclerosis genetics. Mult Scler J. 2018;24(1):75–9.

    Article  CAS  Google Scholar 

  33. Dunn SE, Lee H, Pavri FR and Zhang MA. Sex-based differences in Multiple Sclerosis (Part I): biology of disease incidence. Curr Topics Behav Neurosci. 2015. https://doi.org/10.1007/7854_2015_371.

    Chapter  Google Scholar 

  34. Waubant E. Effect of puberty on multiple sclerosis risk and course. Mult Scler J. 2018;24(1):32–5.

    Article  Google Scholar 

  35. Bove R, Gilmore W. Hormones and MS: risk factors, biomarkers and therapeutic targets. Mult Scler. 2018;24(1):17–21.

    Article  CAS  PubMed  Google Scholar 

  36. Kotzamani D, Panou T, Mastorodemos V, et al. Rising incidence of Multiple Sclerosis in females associated with urbanization. Neurology. 2012;78:1728–35.

    Article  CAS  PubMed  Google Scholar 

  37. Dunn SE, Lee H, Pavri FR and Zhang MA. Sex-based differences in Multiple Sclerosis (Part II): rising incidence of Multiple Sclerosis in women and the vulnerability of men to progression of this disease. Curr Topics Behav Neurosci. 2015. https://doi.org/10.1007/7854_2015_371.

    Chapter  Google Scholar 

  38. Langer-Gould A, Jun W, Lucas R, Smith J, Gonzales E, Amezcua L, Haraszti S, Chen LH, Quach H, James JA, Barcellos LF, Xiang AH. Epstein-Barr virus, cytomegalovirus and multiple sclerosis susceptibility. A multiethnic study. Neurology. 2017;89:130–7.

    Google Scholar 

  39. Degelman ML, Herman KM. Smoking and multiple sclerosis: a systematic review and meta-analysis using the Bradford Hill criteria for causation. Mult Scler Relat Disord. 2017;17:207–16.

    Article  PubMed  Google Scholar 

  40. Shoemaker TJ, Mowry EM. A review of vitamin D supplementation as disease-modifying therapy. Mult Scler J. 2018;24(1):6–11.

    Article  CAS  Google Scholar 

  41. Ponsonby AL, Lucas RM, van der Mei IA, et al. Offspring number, pregnancy, and risk of a first clinical demyelinating event: the AusImmune Study. Neurology. 2012;78:867–74.

    Article  PubMed  Google Scholar 

  42. Bangar S, Shastri A, El-Sayeh H, Cavanna AE. Women with epilepsy: clinically relevant issues. Funct Neurol. 2016;31(3):127–34.

    CAS  PubMed  PubMed Central  Google Scholar 

  43. Foldvary-Schaefer N, Falcone T. Catamenial epilepsy: pathophysiology, diagnosis, and management. Neurology. 2003;61(Suppl 2):S2–15.

    Article  CAS  PubMed  Google Scholar 

  44. Herzog AG. Menstrual disorders in women with epilepsy. Neurology. 2006;66(Suppl 3):S23–8.

    Article  PubMed  Google Scholar 

  45. Morrell MJ. Epilepsy in women: the science of why it is special. Neurology. 1999;53(Suppl 1):S42–8.

    CAS  PubMed  Google Scholar 

  46. Feely M, Gibson J. Intermittent clobazam for catamenial epilepsy: tolerance avoided. J Neurol Neurosurg Psychiatry. 1984;47:1279–82.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  47. Herzog AG, Fowler KM, Smithson SD, et al. Progesterone vs placebo therapy for women with epilepsy: a randomized clinical trial. Neurology. 2012;78:1959–66.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  48. Sabers A, Ohman I, Christensen J, et al. Oral contraceptives reduce lamotrigine plasma levels. Neurology. 2003;61:570571.

    Article  CAS  Google Scholar 

  49. Gaffield ME, Culwell KR, Lee CR. The use of hormonal contraception among women taking anticonvulsant therapy. Contraception. 2011;83:16–29.

    Article  CAS  PubMed  Google Scholar 

  50. O’Brien MD, Guillebaud J. Contraception for women taking antiepileptic drugs. J Fam Plann Reprod Health Care. 2010;36:239–42.

    Article  PubMed  Google Scholar 

  51. Dutton C, Foldvary-Schaefer N. Contraception in women with epilepsy: pharmacokinetic interactions, contraceptive options, and management. Int Rev Neurobiol. 2008;83:113–34.

    Article  PubMed  Google Scholar 

  52. Hu X, Wang J, Dong W, et al. A meta-analysis of polycystic ovary syndrome in women taking valproate for epilepsy. Epilepsy Res. 2011;97:73–82.

    Article  CAS  PubMed  Google Scholar 

  53. Zhou JQ, Zhou LM, Chen LJ, et al. Polycystic ovary syndrome in patients with epilepsy: a study in 102 Chinese women. Seizure. 2012;21:729–33.

    Article  PubMed  Google Scholar 

  54. Morrell MJ, Hayes FJ, Sluss PM, et al. Hyperandrogenism, ovulatory dysfunction, and polycystic ovary syndrome with valproate versus lamotrigine. Ann Neurol. 2008;64:200–11.

    Article  CAS  PubMed  Google Scholar 

  55. Zelená V, Kuba R, Soška V, et al. Depression as a prominent cause of sexual dysfunction in women with epilepsy. Epilepsy Behav. 2011;20:539–44.

    Article  PubMed  Google Scholar 

  56. Harden CL, Meador KJ, Pennell PB, et al. Practice parameter update: management issues for women with epilepsy - focus on pregnancy (an evidence-based review): teratogenesis and perinatal outcomes: report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and American Epilepsy Society. Neurology. 2009;73:133–41.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  57. EURAP Study Group. Seizure control and treatment in pregnancy: observations from the EURAP epilepsy pregnancy registry. Neurology. 2006;66:354–60.

    Article  Google Scholar 

  58. Vajda FJ, Hitchcock A, Graham J, et al. Foetal malformations and seizure control: 52 months data of the Australian Pregnancy Registry. Eur J Neurol. 2006;13:645–54.

    Article  CAS  PubMed  Google Scholar 

  59. Tomson T, Battino D, Bonizzoni E, et al. Comparative risk of major congenital malformations with eight different antiepileptic drugs: a prospective cohort study of the EURAP registry. Lancet Neurol. 2018;17:530–8.

    Article  CAS  PubMed  Google Scholar 

  60. Bromley R, Weston J, Adab N, et al. Treatment for epilepsy in pregnancy: neurodevelopmental outcomes in the child. Cochrane Database Syst Rev. 2014;10:CD010236.

    Google Scholar 

  61. Meador KJ, Baker GA, Browning N, et al. Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs. N Engl J Med. 2009;360:1597–605.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  62. Christensen J, Grønborg TK, Sørensen MJ, et al. Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism. JAMA. 2013;309:1696–703.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  63. Baker GA, Bromley RL, Briggs M, et al. IQ at 6 years after utero exposure to antiepileptic drugs. Neurology. 2015;84:1–9.

    Article  CAS  Google Scholar 

  64. Harden CL, Pennell PB, Koppel BS, et al. Management issues for women with epilepsy – focus on pregnancy (an evidence-based review): III. Vitamin K, folic acid, blood levels, and breast-feeding: Report of the Quality Standards Subcommittee and Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology and the American Epilepsy Society. Epilepsia. 2009;50:1247–55.

    Article  PubMed  Google Scholar 

  65. Crawford P. Best practice guidelines for the management of women with epilepsy. Epilepsia. 2005;46(Suppl 9):117–24.

    Article  PubMed  Google Scholar 

  66. Harden CL, Pulver MC, Ravdin L, et al. The effect of menopause and perimenopause on the course of epilepsy. Epilepsia. 1999;40:1402–7.

    Article  CAS  PubMed  Google Scholar 

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  • Johnson EL, Kaplan PW. Caring for transgender patients with epilepsy. Epilepsia. 2017;58(10):1667–72.

    Article  PubMed  Google Scholar 

  • Katan M, Luft A. Global burden of stroke. Semin Neurol. 2018;38(2):208–11.

    Article  PubMed  Google Scholar 

  • Kuzma E, Lurida I, Moore SF, Levine DA, Okoumunne OC, Llewellyn DJ. Stroke and dementia risk: a systematic review and meta-analysis. Alzheimer’s Dement. 2018;14(11):1416–26.

    Article  Google Scholar 

  • Rankin K, Bove R. Caring for women with Multiple Sclerosis across the lifespan. Curr Neurol Neurosci Rep. 2018;18(7):36.

    Article  PubMed  Google Scholar 

  • Sadr SS, Javanbakht J, Javidan AN, Ghaffarpour M, Khamse S, Naghshband Z. Descriptive epidemiology: prevalence, incidence, sociodemographic factors, socioeconomic domains, and quality of life of epilepsy: an update and systematic review. Arch Med Sci. 2018;14(4):717–24.

    PubMed  Google Scholar 

  • Vetvik KG, MacGregor EA. Sex differences in the epidemiology, clinical features, and pathophysiology of migraine. Lancet Neurol. 2017;16(1):76–87.

    Article  CAS  PubMed  Google Scholar 

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Pastorelli, F., Favoni, V., Cevoli, S., Michelucci, R. (2019). Central and Peripheral Nervous Disorders. In: Tarricone, I., Riecher-Rössler, A. (eds) Health and Gender. Springer, Cham. https://doi.org/10.1007/978-3-030-15038-9_22

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