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DNA Methylation: Biological Implications and Modulation of Its Aberrant Dysregulation

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The DNA, RNA, and Histone Methylomes

Part of the book series: RNA Technologies ((RNATECHN))

Abstract

The alteration of the DNA methylation pattern is often related to the onset of diseases based on epigenetic dysregulation, primarily cancer. In this scenery the development of DNA methyltransferase inhibitors is one of the most attractive challenges for anticancer therapy. The present chapter proposes a comprehensive classification of the DNA methyltransferase inhibitors known in literature, on the basis of their natural or synthetic nature and their mechanism of action.

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  1. Authors “Alessia Lucidi” and “Daniela Tomaselli” have contributed equally to this chapter.

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  1. Department of Chemistry and Technologies of Drugs, Sapienza University of Rome, Roma, Italy

    Alessia Lucidi, Daniela Tomaselli, Dante Rotili & Antonello Mai

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  1. Alessia Lucidi
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  1. Nanobiomedical Center, Adam Mickiewicz University, Poznań, Poland

    Stefan Jurga

  2. Nanobiomedical Center, Adam Mickiewicz University, Poznań, Poland

    Jan Barciszewski

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Lucidi, A., Tomaselli, D., Rotili, D., Mai, A. (2019). DNA Methylation: Biological Implications and Modulation of Its Aberrant Dysregulation. In: Jurga, S., Barciszewski, J. (eds) The DNA, RNA, and Histone Methylomes. RNA Technologies. Springer, Cham. https://doi.org/10.1007/978-3-030-14792-1_12

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