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Sleep, Sleep Disorders, and Immune Function

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Allergy and Sleep

Abstract

The complex interactions between sleep and immune function have been an area of significant interest. Studies have clearly demonstrated that sleep deprivation imposes major adverse effects on host defense mechanisms and on the magnitude and characteristics of the inflammatory response. Consequently, disorders of sleep per se or conversely those disorders affecting sleep homeostasis are increasingly being found to impact on immune function. Here we provide an overview of sleep and the immune system and discuss the current theories regarding sleep disruption and its impact on the immune system. As an example of such potential interactions, we then examine one of the most common pediatric sleep disorders, namely, obstructive sleep apnea (OSA), and illustrate its intricate interactions with the immune system.

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Financial Support

LKG and DG are supported by National Institutes of Health grant HL130984. DG is also supported by the Herbert T. Abelson Chair in Pediatrics.

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Authors and Affiliations

  1. Department of Paediatric Respiratory Medicine, Royal Brompton Hospital, London, UK

    Hui-Leng Tan

  2. Department of Child Health Research Institute, University of Missouri School of Medicine, Columbia, MO, USA

    Leila Kheirandish-Gozal

  3. Department of Child Health, University of Missouri School of Medicine, Columbia, MO, USA

    David Gozal

Authors
  1. Hui-Leng Tan
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  2. Leila Kheirandish-Gozal
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Editors and Affiliations

  1. Northwestern University, Feinberg School of Medicine, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, USA

    Anna Fishbein

  2. Northwestern University, Feinberg School of Medicine, Ann & Robert H. Lurie Children’s Hospital of Chicago, Chicago, IL, USA

    Stephen H. Sheldon

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Tan, HL., Kheirandish-Gozal, L., Gozal, D. (2019). Sleep, Sleep Disorders, and Immune Function. In: Fishbein, A., Sheldon, S. (eds) Allergy and Sleep. Springer, Cham. https://doi.org/10.1007/978-3-030-14738-9_1

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  • DOI: https://doi.org/10.1007/978-3-030-14738-9_1

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