Skip to main content

Delirium: Risk Factors, Contributors, Identification, Work-Up, and Treatment

  • Chapter
  • First Online:
Inpatient Geriatric Psychiatry

Abstract

Delirium is a common, serious, and life-threatening condition that is often missed and poorly managed. Increasing evidence argues that health-care providers need to assess the mental status of the patient as the “sixth vital sign.” Although functional neuroimaging and CSF biomarkers are being studied in delirium management, the diagnosis is a clinical one without a laboratory test or imaging to confirm it.

Delirium is associated with increased morbidity, mortality, slower rate of recovery, poor functional and cognitive recovery, decreased quality of life, hospital-acquired complications, placement in specialized intermediate and long-term care facilities, increased cost of care, and prolonged hospital stays. Management includes the rapid identification of the cause(s), and correcting it/them if possible. Managing risk factors such as dehydration, infection, polypharmacy, immobility, restraints, and sensory impairment is key in both identifying the cause and reducing the consequences and optimizing patient care. This chapter will explore the identification, work-up, risk factors, and management of this important condition.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Downing LJ, Caprio TV, Lyness JM. Geriatric psychiatry review: differential diagnosis and treatment of the 3 D’s – delirium, dementia, and depression. Curr Psychiatry Rep. 2013;15:365.

    Google Scholar 

  2. Leonard M, McInerney S, McFarland J, Condon C, Awan F, O’Connor M, et al. Comparison of cognitive and neuropsychiatric profiles in hospitalised elderly medical patients with delirium, dementia and comorbid delirium–dementia. BMJ Open. 2016;6(3):e009212.

    Article  Google Scholar 

  3. O’Sullivan R, Inouye SK, Meagher D. Delirium and depression: inter-relationship and overlap in elderly people. Lancet Psychiatry. 2014;1(4):303–11.

    Google Scholar 

  4. Hosker C, Ward D. Hypoactive delirium. BMJ. 2017;357:j2047.

    Google Scholar 

  5. Elie M, Rousseau F, Cole M, Primeau F, Mccusker J, Bellavance F. Prevalence and detection of delirium in elderly emergency department patients. CMAJ (Canadian Medical Association Journal = Journal De L’Association Medicale Canadienne). 2000;163(8):977–81.

    CAS  Google Scholar 

  6. Inouye SK, Westendorp RGJ, Saczynski JS. Delirium in elderly people. Lancet. 2014;383(9920):911–22.

    Article  Google Scholar 

  7. Inouye SK, Marcantonio ER, Metzger ED. Doing damage in delirium: the hazards of antipsychotic treatment in elderly persons. Lancet Psychiatry. 2014;1(4):312–5.

    Google Scholar 

  8. Collier R. Hospital-induced delirium hits hard. CMAJ. 2012;184(1):23–4.

    Article  Google Scholar 

  9. Flaherty J, Rudolph J, Shay K, Kamholz B, Boockvar K, Shaughnessy M, et al. Delirium is a serious and under-recognized problem: why assessment of mental status should be the sixth vital sign. J Am Med Dir Assoc. 2007;8(5):273–5.

    Article  Google Scholar 

  10. Oldham MA, Flaherty JH, Maldonado JR. Refining delirium: a transtheoretical model of delirium disorder with preliminary neurophysiologic subtypes. Am J Geriatr Psychiatry. 2018;26(9):913–24.

    Article  Google Scholar 

  11. Witlox J, Eurelings LSM, De Jonghe JFM, Kalisvaart KJ, Eikelenboom P, Van Gool WA. Delirium in elderly patients and the risk of postdischarge mortality, institutionalization, and dementia. (Clinical report). JAMA. 2010;304(4):443–51.

    Article  CAS  Google Scholar 

  12. Saczynski JS, Marcantonio ER, Quach L, Fong TG, Gross A, Inouye SK, Jones RN. Cognitive trajectories after postoperative delirium. N Engl J Med. 2012;367(1):30–9.

    Article  CAS  Google Scholar 

  13. Inouye SK, Marcantonio ER, Kosar CM, Tommet D, Schmitt EM, Travison TG, et al. The short-term and long-term relationship between delirium and cognitive trajectory in older surgical patients. Alzheimers Dement. 2016;12(7):766–75.

    Article  Google Scholar 

  14. Reynish E, Hapca S, De Souza N, Cvoro V, Donnan P, Guthrie B. Epidemiology and outcomes of people with dementia, delirium, and unspecified cognitive impairment in the general hospital: prospective cohort study of 10,014 admissions. BMC Med. 2017;15(1):140.

    Article  Google Scholar 

  15. American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-5. 5th ed. Arlington, VA, US: American Psychiatric Publishing, 2013.

    Google Scholar 

  16. Grover S, Kate N. Assessment scales for delirium: a review. World J Psychiatry. 2012;2(4):58–70.

    Article  Google Scholar 

  17. Vasunilashorn SM, Ngo L, Kosar CM, Fong TG, Jones RN, Inouye SK, Marcantonio ER. Does apolipoprotein E genotype increase risk of postoperative delirium? Am J Geriatr Psychiatry. 2015;23(10):1029–37.

    Article  Google Scholar 

  18. Cavallari M, Dai W, Guttmann C, Meier D, Ngo L, Hshieh T, et al. Neural substrates of vulnerability to postsurgical delirium as revealed by presurgical diffusion MRI. Brain. 2016;139(4):1282–94.

    Article  Google Scholar 

  19. Rockwood K. Causes of delirium. Psychiatry. 2008;7(1):39–41.

    Article  Google Scholar 

  20. Marcantonio ER. Delirium in hospitalized older adults. N Engl J Med. 2017;377:1456–66.

    Article  Google Scholar 

  21. Magny E, Le Petitcorps H, Pociumban M, Bouksani-Kacher Z, Pautas E, Belmin J, Lafuente-Lafuente C. Predisposing and precipitating factors for delirium in community-dwelling older adults admitted to hospital with this condition: a prospective case series. PLoS One. 2018;13(2):E0193034.

    Article  Google Scholar 

  22. Clegg A, Young J. Which medications to avoid in people at risk of delirium: a systematic review. Age Ageing. 2011;40(1):23–9.

    Article  Google Scholar 

  23. Porsteinsson AP, Drye LT, Pollock BG, Devanand DP, Frangakis C, Ismail Z, Marano C, Meinert CL, Mintzer JE, Munro CA, Pelton G, Rabins PV, Rosenberg PB, Schneider LS, Shade DM, Weintraub D, Yesavage J, Lyketsos CG, CitAD Research Group. Effect of citalopram on agitation in Alzheimer disease: the CitAD randomized clinical trial. JAMA. 2014;311(7):682–91.

    Article  CAS  Google Scholar 

  24. Gross P. Clinical management of SIADH. Ther Adv Endocrinol Metabol. 2012;3(2):61–73.

    Article  CAS  Google Scholar 

  25. Dunkley EJ, Isbister GK, Sibbritt D, Dawson AH, Whyte IM. The hunter serotonin toxicity criteria: simple and accurate diagnostic decision rules for serotonin toxicity. QJM. 2003;96(9):635–42.

    Article  CAS  Google Scholar 

  26. Boyer EW, Shannon M. The serotonin syndrome. N Engl J Med. 2005;352(11):1112–20.

    Article  CAS  Google Scholar 

  27. Oruch R, Pryme IF, Engelsen B, Lund A. Neuroleptic malignant syndrome: an easily overlooked neurologic emergency. Neuropsychiatr Dis Treat. 2017;13:161.

    Article  CAS  Google Scholar 

  28. Ballard C, Margallo-Lana M, Juszczak E, Douglas S, Swann A, Thomas A, et al. Quetiapine and rivastigmine and cognitive decline on Alzheimer’s disease: randomized double blind placebo controlled trial. Br Med J. 2005;330(7496):874–7.

    Article  CAS  Google Scholar 

  29. Schuckit MA. Recognition and management of withdrawal delirium (Delirium Tremens). N Engl J Med. 2014;371(22):2109–13.

    Article  Google Scholar 

  30. Anderson BJ, Reilly JP, Shashaty MG, Palakshappa JA, Wysoczanski A, Dunn TG, et al. Admission plasma levels of the neuronal injury marker neuron-specific enolase are associated with mortality and delirium in sepsis. J Crit Care. 2016;36:18–23.

    Article  CAS  Google Scholar 

  31. Young J, Murthy L, Westby M, Akunne A, O’Mahony R. Diagnosis, prevention, and management of delirium: summary of NICE guidance. Br Med J. 2010;28(341):c3704

    Article  Google Scholar 

  32. Zaubler T, Murphy K, Rizzuto L, Santos R, Skotzko C, Giordano J, Bustami R, Inouye SK. Quality improvement and cost savings with multicomponent delirium interventions: replication of the Hospital Elder Life Program in a community hospital. Psychosomatics. 2013;54(3):219–26.

    Article  Google Scholar 

  33. Inouye SK, Bogardus ST Jr, Baker DI, Leo-Summers L, Cooney LM Jr. The Hospital Elder Life Program: a model of care to prevent cognitive and functional decline in older hospitalized patients. J Am Geriatr Soc. 2000;48(12):1697–706.

    Article  CAS  Google Scholar 

  34. Hshieh TT, Yang T, Gartaganis SL, Jirong Yue J, Inouye SK. Hospital elder life program: systematic review and meta-analysis of effectiveness. Am J Geriatr Psychiatry. 2018;26(10):1015–33.

    Article  Google Scholar 

  35. Breitbart W, Marotta R, Platt MM, Weisman H, Derevenco M, Grau C, Corbera K, Raymond S, Lund S, Jacobson P. A double-blind trial of haloperidol, chlorpromazine, and lorazepam in the treatment of delirium in hospitalized AIDS patients. Am J Psychiatry. 1996;153(2):231–7.

    Article  CAS  Google Scholar 

  36. Boettger S, Jenewein J, Breitbart W. Haloperidol, risperidone, olanzapine and aripiprazole in the management of delirium: a comparison of efficacy, safety, and side effects. Palliat Support Care. 2015;13(4):1079–85.

    Article  Google Scholar 

  37. Girard TD, Exline MC, Carson SS, et al. Haloperidol and ziprasidone for treatment of delirium in critical illness. N Engl J Med. 2018;379(26):2506–16.

    Google Scholar 

  38. American Geriatrics Society Abstracted Clinical Practice Guideline for Postoperative Delirium in Older Adults. J Am Geriatr Soc. 2015;63(1):142–50.

    Article  Google Scholar 

  39. Neufeld KJ, Yue J, Robinson TN, Inouye SK, Needham DM. Antipsychotic medication for prevention and treatment of delirium in hospitalized adults: a systematic review and meta-analysis. J Am Geriatr Soc. 2016;64(4):705–14.

    Article  Google Scholar 

  40. Mu JL, Lee AM, Joynt G. Pharmacologic agents for the prevention and treatment of delirium in patients undergoing cardiac surgery: systematic review and metaanalysis. Crit Care Med. 2015;43(1):194–204.

    Article  CAS  Google Scholar 

  41. Cole M, Ciampi A, Belzile E, Zhong L. Persistent delirium in older hospital patients: a systematic review of frequency and prognosis. Age Ageing. 2009;38(1):19–26.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Timothy Lau .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Lau, T., Kozyra, E., Cheng, C. (2019). Delirium: Risk Factors, Contributors, Identification, Work-Up, and Treatment. In: Fenn, H., Hategan, A., Bourgeois, J. (eds) Inpatient Geriatric Psychiatry . Springer, Cham. https://doi.org/10.1007/978-3-030-10401-6_12

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-10401-6_12

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-10400-9

  • Online ISBN: 978-3-030-10401-6

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics