Abstract
Delirium is a common, serious, and life-threatening condition that is often missed and poorly managed. Increasing evidence argues that health-care providers need to assess the mental status of the patient as the “sixth vital sign.” Although functional neuroimaging and CSF biomarkers are being studied in delirium management, the diagnosis is a clinical one without a laboratory test or imaging to confirm it.
Delirium is associated with increased morbidity, mortality, slower rate of recovery, poor functional and cognitive recovery, decreased quality of life, hospital-acquired complications, placement in specialized intermediate and long-term care facilities, increased cost of care, and prolonged hospital stays. Management includes the rapid identification of the cause(s), and correcting it/them if possible. Managing risk factors such as dehydration, infection, polypharmacy, immobility, restraints, and sensory impairment is key in both identifying the cause and reducing the consequences and optimizing patient care. This chapter will explore the identification, work-up, risk factors, and management of this important condition.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Downing LJ, Caprio TV, Lyness JM. Geriatric psychiatry review: differential diagnosis and treatment of the 3 D’s – delirium, dementia, and depression. Curr Psychiatry Rep. 2013;15:365.
Leonard M, McInerney S, McFarland J, Condon C, Awan F, O’Connor M, et al. Comparison of cognitive and neuropsychiatric profiles in hospitalised elderly medical patients with delirium, dementia and comorbid delirium–dementia. BMJ Open. 2016;6(3):e009212.
O’Sullivan R, Inouye SK, Meagher D. Delirium and depression: inter-relationship and overlap in elderly people. Lancet Psychiatry. 2014;1(4):303–11.
Hosker C, Ward D. Hypoactive delirium. BMJ. 2017;357:j2047.
Elie M, Rousseau F, Cole M, Primeau F, Mccusker J, Bellavance F. Prevalence and detection of delirium in elderly emergency department patients. CMAJ (Canadian Medical Association Journal = Journal De L’Association Medicale Canadienne). 2000;163(8):977–81.
Inouye SK, Westendorp RGJ, Saczynski JS. Delirium in elderly people. Lancet. 2014;383(9920):911–22.
Inouye SK, Marcantonio ER, Metzger ED. Doing damage in delirium: the hazards of antipsychotic treatment in elderly persons. Lancet Psychiatry. 2014;1(4):312–5.
Collier R. Hospital-induced delirium hits hard. CMAJ. 2012;184(1):23–4.
Flaherty J, Rudolph J, Shay K, Kamholz B, Boockvar K, Shaughnessy M, et al. Delirium is a serious and under-recognized problem: why assessment of mental status should be the sixth vital sign. J Am Med Dir Assoc. 2007;8(5):273–5.
Oldham MA, Flaherty JH, Maldonado JR. Refining delirium: a transtheoretical model of delirium disorder with preliminary neurophysiologic subtypes. Am J Geriatr Psychiatry. 2018;26(9):913–24.
Witlox J, Eurelings LSM, De Jonghe JFM, Kalisvaart KJ, Eikelenboom P, Van Gool WA. Delirium in elderly patients and the risk of postdischarge mortality, institutionalization, and dementia. (Clinical report). JAMA. 2010;304(4):443–51.
Saczynski JS, Marcantonio ER, Quach L, Fong TG, Gross A, Inouye SK, Jones RN. Cognitive trajectories after postoperative delirium. N Engl J Med. 2012;367(1):30–9.
Inouye SK, Marcantonio ER, Kosar CM, Tommet D, Schmitt EM, Travison TG, et al. The short-term and long-term relationship between delirium and cognitive trajectory in older surgical patients. Alzheimers Dement. 2016;12(7):766–75.
Reynish E, Hapca S, De Souza N, Cvoro V, Donnan P, Guthrie B. Epidemiology and outcomes of people with dementia, delirium, and unspecified cognitive impairment in the general hospital: prospective cohort study of 10,014 admissions. BMC Med. 2017;15(1):140.
American Psychiatric Association. Diagnostic and statistical manual of mental disorders: DSM-5. 5th ed. Arlington, VA, US: American Psychiatric Publishing, 2013.
Grover S, Kate N. Assessment scales for delirium: a review. World J Psychiatry. 2012;2(4):58–70.
Vasunilashorn SM, Ngo L, Kosar CM, Fong TG, Jones RN, Inouye SK, Marcantonio ER. Does apolipoprotein E genotype increase risk of postoperative delirium? Am J Geriatr Psychiatry. 2015;23(10):1029–37.
Cavallari M, Dai W, Guttmann C, Meier D, Ngo L, Hshieh T, et al. Neural substrates of vulnerability to postsurgical delirium as revealed by presurgical diffusion MRI. Brain. 2016;139(4):1282–94.
Rockwood K. Causes of delirium. Psychiatry. 2008;7(1):39–41.
Marcantonio ER. Delirium in hospitalized older adults. N Engl J Med. 2017;377:1456–66.
Magny E, Le Petitcorps H, Pociumban M, Bouksani-Kacher Z, Pautas E, Belmin J, Lafuente-Lafuente C. Predisposing and precipitating factors for delirium in community-dwelling older adults admitted to hospital with this condition: a prospective case series. PLoS One. 2018;13(2):E0193034.
Clegg A, Young J. Which medications to avoid in people at risk of delirium: a systematic review. Age Ageing. 2011;40(1):23–9.
Porsteinsson AP, Drye LT, Pollock BG, Devanand DP, Frangakis C, Ismail Z, Marano C, Meinert CL, Mintzer JE, Munro CA, Pelton G, Rabins PV, Rosenberg PB, Schneider LS, Shade DM, Weintraub D, Yesavage J, Lyketsos CG, CitAD Research Group. Effect of citalopram on agitation in Alzheimer disease: the CitAD randomized clinical trial. JAMA. 2014;311(7):682–91.
Gross P. Clinical management of SIADH. Ther Adv Endocrinol Metabol. 2012;3(2):61–73.
Dunkley EJ, Isbister GK, Sibbritt D, Dawson AH, Whyte IM. The hunter serotonin toxicity criteria: simple and accurate diagnostic decision rules for serotonin toxicity. QJM. 2003;96(9):635–42.
Boyer EW, Shannon M. The serotonin syndrome. N Engl J Med. 2005;352(11):1112–20.
Oruch R, Pryme IF, Engelsen B, Lund A. Neuroleptic malignant syndrome: an easily overlooked neurologic emergency. Neuropsychiatr Dis Treat. 2017;13:161.
Ballard C, Margallo-Lana M, Juszczak E, Douglas S, Swann A, Thomas A, et al. Quetiapine and rivastigmine and cognitive decline on Alzheimer’s disease: randomized double blind placebo controlled trial. Br Med J. 2005;330(7496):874–7.
Schuckit MA. Recognition and management of withdrawal delirium (Delirium Tremens). N Engl J Med. 2014;371(22):2109–13.
Anderson BJ, Reilly JP, Shashaty MG, Palakshappa JA, Wysoczanski A, Dunn TG, et al. Admission plasma levels of the neuronal injury marker neuron-specific enolase are associated with mortality and delirium in sepsis. J Crit Care. 2016;36:18–23.
Young J, Murthy L, Westby M, Akunne A, O’Mahony R. Diagnosis, prevention, and management of delirium: summary of NICE guidance. Br Med J. 2010;28(341):c3704
Zaubler T, Murphy K, Rizzuto L, Santos R, Skotzko C, Giordano J, Bustami R, Inouye SK. Quality improvement and cost savings with multicomponent delirium interventions: replication of the Hospital Elder Life Program in a community hospital. Psychosomatics. 2013;54(3):219–26.
Inouye SK, Bogardus ST Jr, Baker DI, Leo-Summers L, Cooney LM Jr. The Hospital Elder Life Program: a model of care to prevent cognitive and functional decline in older hospitalized patients. J Am Geriatr Soc. 2000;48(12):1697–706.
Hshieh TT, Yang T, Gartaganis SL, Jirong Yue J, Inouye SK. Hospital elder life program: systematic review and meta-analysis of effectiveness. Am J Geriatr Psychiatry. 2018;26(10):1015–33.
Breitbart W, Marotta R, Platt MM, Weisman H, Derevenco M, Grau C, Corbera K, Raymond S, Lund S, Jacobson P. A double-blind trial of haloperidol, chlorpromazine, and lorazepam in the treatment of delirium in hospitalized AIDS patients. Am J Psychiatry. 1996;153(2):231–7.
Boettger S, Jenewein J, Breitbart W. Haloperidol, risperidone, olanzapine and aripiprazole in the management of delirium: a comparison of efficacy, safety, and side effects. Palliat Support Care. 2015;13(4):1079–85.
Girard TD, Exline MC, Carson SS, et al. Haloperidol and ziprasidone for treatment of delirium in critical illness. N Engl J Med. 2018;379(26):2506–16.
American Geriatrics Society Abstracted Clinical Practice Guideline for Postoperative Delirium in Older Adults. J Am Geriatr Soc. 2015;63(1):142–50.
Neufeld KJ, Yue J, Robinson TN, Inouye SK, Needham DM. Antipsychotic medication for prevention and treatment of delirium in hospitalized adults: a systematic review and meta-analysis. J Am Geriatr Soc. 2016;64(4):705–14.
Mu JL, Lee AM, Joynt G. Pharmacologic agents for the prevention and treatment of delirium in patients undergoing cardiac surgery: systematic review and metaanalysis. Crit Care Med. 2015;43(1):194–204.
Cole M, Ciampi A, Belzile E, Zhong L. Persistent delirium in older hospital patients: a systematic review of frequency and prognosis. Age Ageing. 2009;38(1):19–26.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2019 Springer Nature Switzerland AG
About this chapter
Cite this chapter
Lau, T., Kozyra, E., Cheng, C. (2019). Delirium: Risk Factors, Contributors, Identification, Work-Up, and Treatment. In: Fenn, H., Hategan, A., Bourgeois, J. (eds) Inpatient Geriatric Psychiatry . Springer, Cham. https://doi.org/10.1007/978-3-030-10401-6_12
Download citation
DOI: https://doi.org/10.1007/978-3-030-10401-6_12
Published:
Publisher Name: Springer, Cham
Print ISBN: 978-3-030-10400-9
Online ISBN: 978-3-030-10401-6
eBook Packages: MedicineMedicine (R0)