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Clinical and Pathological Features of Selected Human Retinal Degenerative Diseases

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Cell-Based Therapy for Degenerative Retinal Disease

Part of the book series: Stem Cell Biology and Regenerative Medicine ((STEMCELL))

Abstract

The following chapter provides an overview of several important retinal degenerative conditions, with a focus on phenotypic description and correlation with the genetic basis as currently understood. The conditions selected for this chapter have been subdivided into those associated with either a generalized retinal degeneration, such as retinitis pigmentosa, Leber congenital amaurosis, and choroideremia, or those causing degeneration primarily affecting the macula, including age-related macular degeneration, ABCA4 retinal dystrophy, and Best disease. For each condition, coverage is also given to important investigative findings with optical coherence tomography, fundus autofluorescence, retinal angiography, and electrodiagnostic testing in addition to a description of their characteristic clinical features. It is hoped this chapter will enhance the reader’s understanding of the clinical aspects of these conditions and provide a practical link to current research in the field of cell-based therapy.

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Authors and Affiliations

  1. Princess Alexandra Hospital, University of Queensland, Brisbane, QLD, Australia

    Michael C. Hogden

  2. Institute for Genomic Medicine, Columbia University, New York, NY, USA

    Stephen Tsang

  3. Edward S. Harkness Eye Institute, Columbia University Department of Ophthalmology, New York, NY, USA

    Stephen Tsang

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  1. Michael C. Hogden
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  2. Stephen Tsang
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Editors and Affiliations

  1. Institute of Ophthalmology and Visual Science, Rutgers New Jersey Medical School, Newark, NJ, USA

    Marco A. Zarbin

  2. Wilmer Eye Institute, Johns Hopkins University, School of Medicine, Baltimore, MD, USA

    Mandeep S. Singh

  3. Department of Surgery School of Medicine & Hospital Clinic of Barcelona, University of Barcelona, Barcelona, Spain

    Ricardo P. Casaroli-Marano

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Hogden, M.C., Tsang, S. (2019). Clinical and Pathological Features of Selected Human Retinal Degenerative Diseases. In: Zarbin, M., Singh, M., Casaroli-Marano, R. (eds) Cell-Based Therapy for Degenerative Retinal Disease . Stem Cell Biology and Regenerative Medicine. Humana Press, Cham. https://doi.org/10.1007/978-3-030-05222-5_3

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