Abstract
Cutaneous melanoma is unique among cancers in that it can be readily identified through visual examination of the skin surface. In this chapter, we detail patterns of melanoma presentation as well as appropriate clinical assessment to facilitate early diagnosis. The major histogenic types of melanoma are superficial spreading melanoma, nodular melanoma, lentigo maligna melanoma, and acral lentiginous melanoma; each differs in their associations with age, sex, race, anatomic site, ultraviolet exposure, and molecular profile. The cardinal clinical feature of all types of melanoma, however, is change in size, shape, and color, eventually becoming distinctly different from the remainder of a patient’s skin lesions (i.e., the ugly duckling sign). Variant, uncommon clinical presentations of melanoma, such as amelanotic, desmoplastic, and spitzoid types, are summarized. Finally, we outline aids to the diagnosis of melanoma, including established tools, such as photography and dermoscopy, as well as emerging ones like reflectance confocal microscopy, artificial intelligence-based diagnostic systems, electrical impedance spectroscopy, and adhesive patch molecular assays.
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References
Abernethy JL, Soyer HP, Kerl H, Jorizzo JL, White WL (1994) Epidermotropic metastatic malignant melanoma simulating melanoma in situ. A report of 10 examples from two patients. Am J Surg Pathol 18:1140–1149
Adler NR, Wolfe R, Kelly JW, Haydon A, McArthur GA, McLean CA, Mar VJ (2017) Tumour mutation status and sites of metastasis in patients with cutaneous melanoma. Br J Cancer 117:1026–1035. https://doi.org/10.1038/bjc.2017.254
Aitken JF, Janda M, Elwood M, Youl PH, Ring IT, Lowe JB (2006) Clinical outcomes from skin screening clinics within a community-based melanoma screening program. J Am Acad Dermatol 54:105–114. https://doi.org/10.1016/j.jaad.2005.08.072
Alarcon I, Carrera C, Alos L, Palou J, Malvehy J, Puig S (2014) In vivo reflectance confocal microscopy to monitor the response of lentigo maligna to imiquimod. J Am Acad Dermatol 71:49–55. https://doi.org/10.1016/j.jaad.2014.02.043
Albert LS, Fewkes J, Sober AJ (1990) Metastatic lentigo maligna melanoma. J Dermatol Surg Oncol 16:56–58
Andersen WK, Silvers DN (1991) ‘Melanoma? It can’t be melanoma!’ A subset of melanomas that defies clinical recognition. JAMA 266:3463–3465
Argenziano G et al (2006) Dermoscopy improves accuracy of primary care physicians to triage lesions suggestive of skin cancer. J Clin Oncol 24:1877–1882. https://doi.org/10.1200/JCO.2005.05.0864
Argenziano G et al (2012) Accuracy in melanoma detection: a 10-year multicenter survey. J Am Acad Dermatol 67:54–59. https://doi.org/10.1016/j.jaad.2011.07.019
Arrington JH, Reed RJ, Ichinose H, Krementz ET (1977) Plantar lentiginous melanoma: a distinctive variant of human cutaneous malignant melanoma. Am J Surg Pathol 1:131–143
Aviles-Izquierdo JA, Molina-Lopez I, Rodriguez-Lomba E, Marquez-Rodas I, Suarez-Fernandez R, Lazaro-Ochaita P (2016) Who detects melanoma? Impact of detection patterns on characteristics and prognosis of patients with melanoma. J Am Acad Dermatol 75:967–974. https://doi.org/10.1016/j.jaad.2016.07.009
Bafounta ML, Beauchet A, Aegerter P, Saiag P (2001) Is dermoscopy (epiluminescence microscopy) useful for the diagnosis of melanoma? Results of a meta-analysis using techniques adapted to the evaluation of diagnostic tests. Arch Dermatol 137:1343–1350
Baran R, Kechijian P (1996) Hutchinson’s sign: a reappraisal. J Am Acad Dermatol 34:87–90
Baran LR, Ruben BS, Kechijian P, Thomas L (2018) Non-melanoma Hutchinson’s sign: a reappraisal of this important, remarkable melanoma simulant. J Eur Acad Dermatol Venereol 32:495–501. https://doi.org/10.1111/jdv.14715
Bastian BC (2014) The molecular pathology of melanoma: an integrated taxonomy of melanocytic neoplasia. Annu Rev Pathol 9:239–271. https://doi.org/10.1146/annurev-pathol-012513-104658
Berbaum KS, El-Khoury GY, Ohashi K, Schartz KM, Caldwell RT, Madsen M, Franken EA Jr (2007) Satisfaction of search in multitrauma patients: severity of detected fractures. Acad Radiol 14:711–722. https://doi.org/10.1016/j.acra.2007.02.016
Berlin L (2014) Radiologic errors, past, present and future. Diagnosi 1:79–84. https://doi.org/10.1515/dx-2013-0012
Betti R, Vergani R, Tolomio E, Santambrogio R, Crosti C (2003) Factors of delay in the diagnosis of melanoma. Eur J Dermatol 13:183–188
Bibbins-Domingo K et al (2016) Screening for skin cancer: US preventive services task force recommendation statement. JAMA 316:429–435. https://doi.org/10.1001/jama.2016.8465
Bowen JL (2006) Educational strategies to promote clinical diagnostic reasoning. N Engl J Med 355: 2217–2225. https://doi.org/10.1056/NEJMra054782
Bradford PT, Freedman DM, Goldstein AM, Tucker MA (2010) Increased risk of second primary cancers after a diagnosis of melanoma. Arch Dermatol 146:265–272. https://doi.org/10.1001/archdermatol.2010.2
Brady MS, Oliveria SA, Christos PJ, Berwick M, Coit DG, Katz J, Halpern AC (2000) Patterns of detection in patients with cutaneous melanoma. Cancer 89:342–347
Braga JC, Scope A, Klaz I, Mecca P, Spencer P, Marghoob AA (2008) Melanoma mimicking seborrheic keratosis: an error of perception precluding correct dermoscopic diagnosis. J Am Acad Dermatol 58:875–880. https://doi.org/10.1016/j.jaad.2007.12.011
Braun RP et al (2007a) Diagnosis and management of nail pigmentations. J Am Acad Dermatol 56:835–847. https://doi.org/10.1016/j.jaad.2006.12.021
Braun RP, Gaide O, Skaria AM, Kopf AW, Saurat JH, Marghoob AA (2007b) Exclusively benign dermoscopic pattern in a patient with acral melanoma. Arch Dermatol 143:1213–1215; author reply 1215–1216. https://doi.org/10.1001/archderm.143.9.1213-b
Braun RP, Scope A, Marghoob AA (2011) The “blink sign” in dermoscopy. Arch Dermatol 147:520. https://doi.org/10.1001/archdermatol.2011.82
Broekaert SM et al (2010) Genetic and morphologic features for melanoma classification. Pigment Cell Melanoma Res 23:763–770. https://doi.org/10.1111/j.1755-148X.2010.00778.x
Bron JL, Jaspars EH, Molenkamp BG, Meijer S, Mooi WJ, van Leeuwen PA (2005) Three patients with a Spitz naevus that later turned out to be a melanoma. Ned Tijdschr Geneeskd 149:1852–1858
Bruijn JA, Mihm MC Jr, Barnhill RL (1992) Desmoplastic melanoma. Histopathology 20:197–205
Busam KJ (2005) Cutaneous desmoplastic melanoma. Adv Anat Pathol 12:92–102
Busam KJ, Pulitzer M (2008) Sentinel lymph node biopsy for patients with diagnostically controversial Spitzoid melanocytic tumors? Adv Anat Pathol 15:253–262. https://doi.org/10.1097/PAP.0b013e31818323ac
Busam KJ, Mujumdar U, Hummer AJ, Nobrega J, Hawkins WG, Coit DG, Brady MS (2004) Cutaneous desmoplastic melanoma: reappraisal of morphologic heterogeneity and prognostic factors. Am J Surg Pathol 28:1518–1525
Carli P, De Giorgi V, Chiarugi A, Stante M, Giannotti B (2002) Multiple synchronous cutaneous melanomas: implications for prevention. Int J Dermatol 41:583–585
Carli P et al (2004a) Addition of dermoscopy to conventional naked-eye examination in melanoma screening: a randomized study. J Am Acad Dermatol 50:683–689. https://doi.org/10.1016/j.jaad.2003.09.009
Carli P, De Giorgi V, Crocetti E, Mannone F, Massi D, Chiarugi A, Giannotti B (2004b) Improvement of malignant/benign ratio in excised melanocytic lesions in the ‘dermoscopy era’: a retrospective study 1997–2001. Br J Dermatol 150:687–692. https://doi.org/10.1111/j.0007-0963.2004.05860.x
Carli P et al (2004c) Self-detected cutaneous melanomas in Italian patients. Clin Exp Dermatol 29:593–596. https://doi.org/10.1111/j.1365-2230.2004.01628.x
Carli P, Chiarugi A, De Giorgi V (2005) Examination of lesions (including dermoscopy) without contact with the patient is associated with improper management in about 30% of equivocal melanomas. Dermatol Surg 31:169–172
Carrera C et al (2016) Validity and reliability of Dermoscopic criteria used to differentiate nevi from melanoma: a web-based international dermoscopy society study. JAMA Dermatol 152:798–806. https://doi.org/10.1001/jamadermatol.2016.0624
Carrera C et al (2017) Dermoscopic clues for diagnosing melanomas that resemble seborrheic keratosis. JAMA Dermatol 153:544–551. https://doi.org/10.1001/jamadermatol.2017.0129
Cassileth BR et al (1988) Patient and physician delay in melanoma diagnosis. J Am Acad Dermatol 18:591–598
Chamberlain AJ, Kelly JW (2004) Nodular melanomas and older men: a major challenge for community surveillance programs. Med J Aust 180:432
Chamberlain A, Ng J (2009) Cutaneous melanoma–atypical variants and presentations. Aust Fam Physician 38:476–482
Chamberlain AJ, Fritschi L, Giles GG, Dowling JP, Kelly JW (2002) Nodular type and older age as the most significant associations of thick melanoma in Victoria, Australia. Arch Dermatol 138:609–614
Chamberlain AJ, Fritschi L, Kelly JW (2003) Nodular melanoma: patients’ perceptions of presenting features and implications for earlier detection. J Am Acad Dermatol 48:694–701. https://doi.org/10.1067/mjd.2003.216
Chang AE, Karnell LH, Menck HR (1998) The National Cancer Data Base report on cutaneous and noncutaneous melanoma: a summary of 84,836 cases from the past decade. The American College of Surgeons Commission on Cancer and the American Cancer Society. Cancer 83:1664–1678
Chao E, Meenan CK, Ferris LK (2017) Smartphone-based applications for skin monitoring and melanoma detection. Dermatol Clin 35:551–557. https://doi.org/10.1016/j.det.2017.06.014
Chen JY et al (2008) Desmoplastic neurotropic melanoma: a clinicopathologic analysis of 128 cases. Cancer 113:2770–2778. https://doi.org/10.1002/cncr.23895
Chen T, Fallah M, Forsti A, Kharazmi E, Sundquist K, Hemminki K (2015) Risk of next melanoma in patients with familial and sporadic melanoma by number of previous melanomas. JAMA Dermatol 151:607–615. https://doi.org/10.1001/jamadermatol.2014.4777
Christos PJ et al (2000) Signs and symptoms of melanoma in older populations. J Clin Epidemiol 53:1044–1053
Clarke LE et al (2017) An independent validation of a gene expression signature to differentiate malignant melanoma from benign melanocytic nevi. Cancer 123:617–628. https://doi.org/10.1002/cncr.30385
Cohen LM (1995) Lentigo maligna and lentigo maligna melanoma. J Am Acad Dermatol 33:923–936; quiz 937–940
Cohen PR (2001) Metastatic tumors to the nail unit: subungual metastases. Dermatol Surg 27:280–293
Costa C, Megna M, Cappello M, Napolitano M, Monfrecola G, Scalvenzi M (2017) Melanoma frequency among symmetrical Spitzoid-looking lesions: a retrospective study. G Ital Dermatol Venereol. https://doi.org/10.23736/s0392-0488.17.05523-7
Crombie IK (1979) Racial differences in melanoma incidence. Br J Cancer 40:185–193
Cummins DL, Esche C, Barrett TL, Balch CM, Mofid M (2007) Lymph node biopsy results for desmoplastic malignant melanoma. Cutis 79:390–394
Curchin DJ, Harris VR, McCormack CJ, Smith SD (2018) Changing trends in the incidence of invasive melanoma in Victoria, 1985–2015. Med J Aust 208:265–269
Curtin JA et al (2005) Distinct sets of genetic alterations in melanoma. N Engl J Med 353:2135–2147. https://doi.org/10.1056/NEJMoa050092
Cust AE et al (2013) MC1R genotype as a predictor of early-onset melanoma, compared with self-reported and physician-measured traditional risk factors: an Australian case-control-family study. BMC Cancer 13:406. https://doi.org/10.1186/1471-2407-13-406
Dimitrakopoulos I, Lazaridis N, Skordalaki A (1998) Primary malignant melanoma of the oral cavity. Report of an unusual case. Aust Dent J 43:379–381
Dunne JA, Wormald JC, Steele J, Woods E, Odili J, Powell BW (2017) Is sentinel lymph node biopsy warranted for desmoplastic melanoma? A systematic review. J Plast Reconstr Aesthet Surg 70:274–280. https://doi.org/10.1016/j.bjps.2016.11.003
Ebenezer J (2006) Malignant melanoma of the oral cavity. Indian J Dent Res 17:94–96
Epstein DS, Lange JR, Gruber SB, Mofid M, Koch SE (1999) Is physician detection associated with thinner melanomas? JAMA 281:640–643
Esteva A, Kuprel B, Novoa RA, Ko J, Swetter SM, Blau HM, Thrun S (2017) Dermatologist-level classification of skin cancer with deep neural networks. Nature 542:115–118. https://doi.org/10.1038/nature21056
Feit NE, Dusza SW, Marghoob AA (2004) Melanomas detected with the aid of total cutaneous photography. Br J Dermatol 150:706–714. https://doi.org/10.1111/j.0007-0963.2004.05892.x
Ferris LK et al (2017a) Utility of a noninvasive 2-gene molecular assay for cutaneous melanoma and effect on the decision to biopsy. JAMA Dermatol 153:675–680. https://doi.org/10.1001/jamadermatol.2017.0473
Ferris LK et al (2017b) A large skin Cancer screening quality initiative: description and first-year outcomes. JAMA Oncol 3:1112–1115. https://doi.org/10.1001/jamaoncol.2016.6779
Ferrone CR, Ben Porat L, Panageas KS, Berwick M, Halpern AC, Patel A, Coit DG (2005) Clinicopathological features of and risk factors for multiple primary melanomas. JAMA 294:1647–1654. https://doi.org/10.1001/jama.294.13.1647
Fisher NM, Schaffer JV, Berwick M, Bolognia JL (2005) Breslow depth of cutaneous melanoma: impact of factors related to surveillance of the skin, including prior skin biopsies and family history of melanoma. J Am Acad Dermatol 53:393–406. https://doi.org/10.1016/j.jaad.2005.03.004
Flores ES, Cordova M, Kose K, Phillips W, Rossi A, Nehal K, Rajadhyaksha M (2015) Intraoperative imaging during Mohs surgery with reflectance confocal microscopy: initial clinical experience. J Biomed Opt 20:61103. https://doi.org/10.1117/1.jbo.20.6.061103
Fox GN (2005) ABCD-EFG for diagnosis of melanoma. Clin Exp Dermatol 30:707. https://doi.org/10.1111/j.1365-2230.2005.01857.x
Freeman EE et al (2018) Smartphone confocal microscopy for imaging cellular structures in human skin in vivo. Biomed Opt Express 9:1906–1915. https://doi.org/10.1364/boe.9.001906
Friedman RJ, Rigel DS, Kopf AW (1985) Early detection of malignant melanoma: the role of physician examination and self-examination of the skin. CA Cancer J Clin 35:130–151
Gachon J et al (2005) First prospective study of the recognition process of melanoma in dermatological practice. Arch Dermatol 141:434–438. https://doi.org/10.1001/archderm.141.4.434
Gaudy-Marqueste C et al (2017) Ugly duckling sign as a major factor of efficiency in melanoma detection. JAMA Dermatol 153:279–284. https://doi.org/10.1001/jamadermatol.2016.5500
Gelbard SN, Tripp JM, Marghoob AA, Kopf AW, Koenig KL, Kim JY, Bart RS (2002) Management of Spitz nevi: a survey of dermatologists in the United States. J Am Acad Dermatol 47:224–230
Geller AC, Swetter SM, Brooks K, Demierre MF, Yaroch AL (2007) Screening, early detection, and trends for melanoma: current status (2000–2006) and future directions. J Am Acad Dermatol 57:555–572; quiz 573-556. https://doi.org/10.1016/j.jaad.2007.06.032
Gerami P, Shea C, Stone MS (2006) Angiotropism in epidermotropic metastatic melanoma: another clue to the diagnosis. Am J Dermatopathol 28:429–433. https://doi.org/10.1097/01.dad.0000204761.40199.3f
Gerami P et al (2017) Development and validation of a noninvasive 2-gene molecular assay for cutaneous melanoma. J Am Acad Dermatol 76:114–120.e112. https://doi.org/10.1016/j.jaad.2016.07.038
Gibbs DC et al (2015) Inherited genetic variants associated with occurrence of multiple primary melanoma. Cancer Epidemiol Biomark Prev 24:992–997. https://doi.org/10.1158/1055-9965.epi-14-1426
Goldberg MS, Doucette JT, Lim HW, Spencer J, Carucci JA, Rigel DS (2007) Risk factors for presumptive melanoma in skin cancer screening: American Academy of Dermatology National Melanoma/skin cancer screening program experience 2001–2005. J Am Acad Dermatol 57:60–66. https://doi.org/10.1016/j.jaad.2007.02.010
Goodson AG, Florell SR, Hyde M, Bowen GM, Grossman D (2010) Comparative analysis of total body and dermatoscopic photographic monitoring of nevi in similar patient populations at risk for cutaneous melanoma. Dermatol Surg 36:1087–1098. https://doi.org/10.1111/j.1524-4725.2010.01589.x
Grob JJ, Bonerandi JJ (1998) The ‘ugly duckling’ sign: identification of the common characteristics of nevi in an individual as a basis for melanoma screening. Arch Dermatol 134:103–104
Guitera P, Li LX, Crotty K, Fitzgerald P, Mellenbergh R, Pellacani G, Menzies SW (2008) Melanoma histological Breslow thickness predicted by 75-MHz ultrasonography. Br J Dermatol 159:364–369. https://doi.org/10.1111/j.1365-2133.2008.08681.x
Guitera P, Pellacani G, Longo C, Seidenari S, Avramidis M, Menzies SW (2009) In vivo reflectance confocal microscopy enhances secondary evaluation of melanocytic lesions. J Invest Dermatol 129:131–138. https://doi.org/10.1038/jid.2008.193
Gutman D, Codella NC, Celebi E, Helba B, Marchetti M, Mishra N, Halpern A (2016) Skin lesion analysis toward melanoma detection: a challenge at the international symposium on biomedical imaging (ISBI) 2016, hosted by the International skin imaging collaboration (ISIC), arXiv preprint arXiv,160501397
Haenssle HA et al (2006) Results from an observational trial: digital epiluminescence microscopy follow-up of atypical nevi increases the sensitivity and the chance of success of conventional dermoscopy in detecting melanoma. J Invest Dermatol 126:980–985. https://doi.org/10.1038/sj.jid.5700119
Haenssle HA et al (2018) Man against machine: diagnostic performance of a deep learning convolutional neural network for dermoscopic melanoma recognition in comparison to 58 dermatologists. Ann Oncol. https://doi.org/10.1093/annonc/mdy166
Han SS, Kim MS, Lim W, Park GH, Park I, Chang SE (2018) Classification of the clinical images for benign and malignant cutaneous Tumors using a deep learning algorithm. J Invest Dermatol. https://doi.org/10.1016/j.jid.2018.01.028
Haneke E, Baran R (2001) Longitudinal melanonychia. Dermatol Surg 27:580–584
Haniffa MA, Lloyd JJ, Lawrence CM (2007) The use of a spectrophotometric intracutaneous analysis device in the real-time diagnosis of melanoma in the setting of a melanoma screening clinic. Br J Dermatol 156: 1350–1352. https://doi.org/10.1111/j.1365-2133.2007.07932.x
Hawkins WG et al (2005) Desmoplastic melanoma: a pathologically and clinically distinct form of cutaneous melanoma. Ann Surg Oncol 12:207–213. https://doi.org/10.1245/aso.2005.03.022
Hayward NK et al (2017) Whole-genome landscapes of major melanoma subtypes. Nature 545:175–180. https://doi.org/10.1038/nature22071
Hennrikus D, Girgis A, Redman S, Sanson-Fisher RW (1991) A community study of delay in presenting with signs of melanoma to medical practitioners. Arch Dermatol 127:356–361
Herschorn A (2012) Dermoscopy for melanoma detection in family practice. Can Fam Physician 58:740–745, e372–748
Hibler BP, Cordova M, Wong RJ, Rossi AM (2015) Intraoperative real-time reflectance confocal microscopy for guiding surgical margins of lentigo maligna melanoma. Dermatol Surg 41:980–983. https://doi.org/10.1097/dss.0000000000000401
Hibler BP, Yelamos O, Cordova M, Sierra H, Rajadhyaksha M, Nehal KS, Rossi AM (2017) Handheld reflectance confocal microscopy to aid in the management of complex facial lentigo maligna. Cutis 99:346–352
Hofmann-Wellenhof R, Blum A, Wolf IH, Piccolo D, Kerl H, Garbe C, Soyer HP (2001) Dermoscopic classification of atypical melanocytic nevi (Clark nevi). Arch Dermatol 137:1575–1580
Horsham C, Loescher LJ, Whiteman DC, Soyer HP, Janda M (2016) Consumer acceptance of patient-performed mobile teledermoscopy for the early detection of melanoma. Br J Dermatol 175:1301–1310. https://doi.org/10.1111/bjd.14630
ISIC Archive. https://isic-archive.com/. Accessed 8 Mar 2018
Janda M, Youl PH, Lowe JB, Baade PD, Elwood M, Ring IT, Aitken JF (2006) What motivates men age > or =50 years to participate in a screening program for melanoma? Cancer 107:815–823. https://doi.org/10.1002/cncr.22051
Katalinic A et al (2012) Does skin cancer screening save lives? An observational study comparing trends in melanoma mortality in regions with and without screening. Cancer 118:5395–5402. https://doi.org/10.1002/cncr.27566
Keefe M, Dick DC, Wakeel RA (1990) A study of the value of the seven-point checklist in distinguishing benign pigmented lesions from melanoma. Clin Exp Dermatol 15:167–171
Kelly JW, Yeatman JM, Regalia C, Mason G, Henham AP (1997) A high incidence of melanoma found in patients with multiple dysplastic naevi by photographic surveillance. Med J Aust 167:191–194
Kelly JW, Chamberlain AJ, Staples MP, McAvoy B (2003) Nodular melanoma. No longer as simple as ABC. Aust Fam Physician 32:706–709
Kittler H, Seltenheim M, Dawid M, Pehamberger H, Wolff K, Binder M (1999) Morphologic changes of pigmented skin lesions: a useful extension of the ABCD rule for dermatoscopy. J Am Acad Dermatol 40:558–562
Kittler H, Pehamberger H, Wolff K, Binder M (2002) Diagnostic accuracy of dermoscopy. Lancet Oncol 3:159–165
Kittler H et al (2006) Identification of clinically featureless incipient melanoma using sequential dermoscopy imaging. Arch Dermatol 142:1113–1119. https://doi.org/10.1001/archderm.142.9.1113
Koh HK et al (1984) Lentigo maligna melanoma has no better prognosis than other types of melanoma. J Clin Oncol 2:994–1001. https://doi.org/10.1200/jco.1984.2.9.994
Koh HK, Miller DR, Geller AC, Clapp RW, Mercer MB, Lew RA (1992) Who discovers melanoma? Patterns from a population-based survey. J Am Acad Dermatol 26:914–919
Kopf AW, Salopek TG, Slade J, Marghoob AA, Bart RS (1995) Techniques of cutaneous examination for the detection of skin cancer. Cancer 75:684–690
Korotkov K, Quintana J, Puig S, Malvehy J, Garcia R (2015) A new total body scanning system for automatic change detection in multiple pigmented skin lesions. IEEE Trans Med Imaging 34:317–338. https://doi.org/10.1109/tmi.2014.2357715
Kose K et al (2017) Automated video-mosaicking approach for confocal microscopic imaging in vivo: an approach to address challenges in imaging living tissue and extend field of view. Sci Rep 7:10759. https://doi.org/10.1038/s41598-017-11072-9
Krupinski EA (2005) Visual search of mammographic images: influence of lesion subtlety. Acad Radiol 12:965–969. https://doi.org/10.1016/j.acra.2005.03.071
Krupinski EA et al (2006) Eye-movement study and human performance using telepathology virtual slides: implications for medical education and differences with experience. Hum Pathol 37:1543–1556. https://doi.org/10.1016/j.humpath.2006.08.024
Kundel HL (2006) History of research in medical image perception. J Am Coll Radiol 3:402–408. https://doi.org/10.1016/j.jacr.2006.02.023
Lallas A et al (2014) Atypical Spitz tumours and sentinel lymph node biopsy: a systematic review. Lancet Oncol 15:e178–e183. https://doi.org/10.1016/s1470-2045(13)70608-9
Lallas A et al (2015) Likelihood of finding melanoma when removing a Spitzoid-looking lesion in patients aged 12 years or older. J Am Acad Dermatol 72:47–53. https://doi.org/10.1016/j.jaad.2014.09.037
Leachman SA et al (2009) Selection criteria for genetic assessment of patients with familial melanoma. J Am Acad Dermatol 61:677.e671-614. https://doi.org/10.1016/j.jaad.2009.03.016
Leyden JJ, Spott DA, Goldschmidt H (1972) Diffuse and banded melanin pigmentation in nails. Arch Dermatol 105:548–550
Lin MJ, Mar V, McLean C, Wolfe R, Kelly JW (2014) Diagnostic accuracy of malignant melanoma according to subtype. Australas J Dermatol 55:35–42. https://doi.org/10.1111/ajd.12121
Liu W et al (2005) What features do patients notice that help to distinguish between benign pigmented lesions and melanomas? The ABCD(E) rule versus the seven-point checklist. Melanoma Res 15:549–554
Liu W, Dowling JP, Murray WK, McArthur GA, Thompson JF, Wolfe R, Kelly JW (2006) Rate of growth in melanomas: characteristics and associations of rapidly growing melanomas. Arch Dermatol 142:1551–1558. https://doi.org/10.1001/archderm.142.12.1551
Liu W et al (2007) Distinct clinical and pathological features are associated with the BRAF(T1799A(V600E)) mutation in primary melanoma. J Invest Dermatol 127:900–905. https://doi.org/10.1038/sj.jid.5700632
Luo S, Sepehr A, Tsao H (2011a) Spitz nevi and other Spitzoid lesions part I. Background and diagnoses. J Am Acad Dermatol 65:1073–1084. https://doi.org/10.1016/j.jaad.2011.04.040
Luo S, Sepehr A, Tsao H (2011b) Spitz nevi and other Spitzoid lesions part II. Natural history and management. J Am Acad Dermatol 65:1087–1092. https://doi.org/10.1016/j.jaad.2011.06.045
Luttrell MJ, Hofmann-Wellenhof R, Fink-Puches R, Soyer HP (2011) The AC rule for melanoma: a simpler tool for the wider community. J Am Acad Dermatol 65:1233–1234. https://doi.org/10.1016/j.jaad.2011.05.012
Maj M et al (2015) High frequency ultrasonography: a complementary diagnostic method in evaluation of primary cutaneous melanoma. G Ital Dermatol Venereol 150:595–601
Maldonado JL et al (2003) Determinants of BRAF mutations in primary melanomas. J Natl Cancer Inst 95:1878–1890
Malvehy J et al (2014) Clinical performance of the Nevisense system in cutaneous melanoma detection: an international, multi-centre, prospective and blinded clinical trial on efficacy and safety. Br J Dermatol. https://doi.org/10.1111/bjd.13121
Manahan MN et al (2015) A pilot trial of mobile, patient-performed teledermoscopy. Br J Dermatol 172:1072–1080. https://doi.org/10.1111/bjd.13550
Mancebo SE, Marchetti MA, Hollmann TJ, Marghoob AA, Busam KJ, Halpern AC (2015) Melanoma in situ colonizing basal cell carcinoma: a case report and review of the literature. Dermatol Pract Concept 5:25–30. https://doi.org/10.5826/dpc.0501a04
Manci EA, Balch CM, Murad TM, Soong SJ (1981) Polypoid melanoma, a virulent variant of the nodular growth pattern. Am J Clin Pathol 75:810–815
Mann G, A/Prof Anne Cust, Damian D, Dr Paul Fishburn, Kelly J, Victoria Mar MBBS, FACD, PhD, Soyer P, Cancer Council Australia Melanoma Guidelines Working Party Cancer Council Australia Melanoma Guidelines Working Party. Clinical practice guidelines for the diagnosis and management of melanoma. Cancer Council Australia, Sydney. https://wiki.cancer.org.au/australiawiki/index.php?oldid=186153. Accessed 20 June 2018
Mar V, Roberts H, Wolfe R, English DR, Kelly JW (2013a) Nodular melanoma: a distinct clinical entity and the largest contributor to melanoma deaths in Victoria, Australia. J Am Acad Dermatol 68:568–575. https://doi.org/10.1016/j.jaad.2012.09.047
Mar VJ et al (2013b) BRAF/NRAS wild-type melanomas have a high mutation load correlating with histologic and molecular signatures of UV damage. Clin Cancer Res 19:4589–4598. https://doi.org/10.1158/1078-0432.ccr-13-0398
Mar VJ, Chamberlain AJ, Kelly JW, Murray WK, Thompson JF (2017) Clinical practice guidelines for the diagnosis and management of melanoma: melanomas that lack classical clinical features. Med J Aust 207:348–350
Marchetti MA, Chung E, Halpern AC (2015) Screening for Acral lentiginous melanoma in dark-skinned individuals. JAMA Dermatol 151:1055–1056. https://doi.org/10.1001/jamadermatol.2015.1347
Marchetti MA et al (2018) Results of the 2016 international skin imaging collaboration international symposium on biomedical imaging challenge: comparison of the accuracy of computer algorithms to dermatologists for the diagnosis of melanoma from dermoscopic images. J Am Acad Dermatol:78, 270–277.e271. https://doi.org/10.1016/j.jaad.2017.08.016
Marek AJ, Chu EY, Ming ME, Kovarik CL (2016) Assessment of smartphone applications for total body digital photography-guided skin exams by patients. J Am Acad Dermatol 75:1063–1064.e1061. https://doi.org/10.1016/j.jaad.2016.06.005
Marghoob AA (1999) The dangers of atypical mole (dysplastic nevus) syndrome. Teaching at-risk patients to protect themselves from melanoma. Postgrad Med 105:147–148, 151-142, 154 passim. https://doi.org/10.3810/pgm.1999.06.624
Marghoob AA, Scope A (2009) The complexity of diagnosing melanoma. J Invest Dermatol 129:11–13. https://doi.org/10.1038/jid.2008.388
Marghoob AA, Slade J, Kopf AW, Salopek TG, Rigel DS, Bart RS (1996) Risk of developing multiple primary cutaneous melanomas in patients with the classic atypical-mole syndrome: a case-control study. Br J Dermatol 135:704–711
Marghoob AA, Korzenko AJ, Changchien L, Scope A, Braun RP, Rabinovitz H (2007) The beauty and the beast sign in dermoscopy. Dermatol Surg 33:1388–1391. https://doi.org/10.1111/j.1524-4725.2007.33298.x
Martorell-Calatayud A et al (2011) Defining fast-growing melanomas: reappraisal of epidemiological, clinical, and histological features. Melanoma Res 21:131–138. https://doi.org/10.1097/CMR.0b013e328342f312
Maurichi A et al (2010) Pure desmoplastic melanoma: a melanoma with distinctive clinical behavior. Ann Surg 252:1052–1057. https://doi.org/10.1097/SLA.0b013e3181efc23c
McCormack CJ et al (2014) Atypical Spitzoid neoplasms: a review of potential markers of biological behavior including sentinel node biopsy. Melanoma Res 24:437–447. https://doi.org/10.1097/cmr.0000000000000084
McGovern TW, Litaker MS (1992) Clinical predictors of malignant pigmented lesions. A comparison of the Glasgow seven-point checklist and the American Cancer Society’s ABCDs of pigmented lesions. J Dermatol Surg Oncol 18:22–26
McKenna JK, Florell SR, Goldman GD, Bowen GM (2006) Lentigo maligna/lentigo maligna melanoma: current state of diagnosis and treatment. Dermatol Surg 32:493–504. https://doi.org/10.1111/j.1524-4725.2006.32102.x
McLaughlin CC, Wu XC, Jemal A, Martin HJ, Roche LM, Chen VW (2005) Incidence of noncutaneous melanomas in the U.S. Cancer 103:1000–1007. https://doi.org/10.1002/cncr.20866
McPherson M, Elwood M, English DR, Baade PD, Youl PH, Aitken JF (2006) Presentation and detection of invasive melanoma in a high-risk population. J Am Acad Dermatol 54:783–792. https://doi.org/10.1016/j.jaad.2005.08.065
Mehregan DA, Bergeon MT, Mehregan DR (1995) Epidermotropic metastatic malignant melanoma. Cutis 55:225–227
Menge TD, Hibler BP, Cordova MA, Nehal KS, Rossi AM (2016) Concordance of handheld reflectance confocal microscopy (RCM) with histopathology in the diagnosis of lentigo maligna (LM): a prospective study. J Am Acad Dermatol 74:1114–1120. https://doi.org/10.1016/j.jaad.2015.12.045
Menzies SW et al (2008) Dermoscopic evaluation of amelanotic and hypomelanotic melanoma. Arch Dermatol 144:1120–1127. https://doi.org/10.1001/archderm.144.9.1120
Menzies SW et al (2013) Dermoscopic evaluation of nodular melanoma. JAMA Dermatol 149:699–709. https://doi.org/10.1001/jamadermatol.2013.2466
Meyer N et al (2014) High-frequency ultrasonography but not 930-nm optical coherence tomography reliably evaluates melanoma thickness in vivo: a prospective validation study. Br J Dermatol 171:799–805. https://doi.org/10.1111/bjd.13129
Molina D, Sanchez JL (1995) Pigmented longitudinal bands of the nail. A clinicopathologic study. Am J Dermatopathol 17:539–541
Moloney FJ et al (2014) Detection of primary melanoma in individuals at extreme high risk: a prospective 5-year follow-up study. JAMA Dermatol 150:819–827. https://doi.org/10.1001/jamadermatol.2014.514
Monheit G et al (2011) The performance of MelaFind: a prospective multicenter study. Arch Dermatol 147:188–194. https://doi.org/10.1001/archdermatol.2010.302
Morris JB, Alfonso SV, Hernandez N, Fernandez MI (2017) Use of and intentions to use dermoscopy among physicians in the United States. Dermatol Pract Concept 7:7–16. https://doi.org/10.5826/dpc.0702a02
Moynihan GD (1994) The 3 Cs of melanoma: time for a change? J Am Acad Dermatol 30:510–511
Murali R et al (2010) Prognostic factors in cutaneous desmoplastic melanoma: a study of 252 patients. Cancer 116:4130–4138. https://doi.org/10.1002/cncr.25148
Murzaku EC, Hayan S, Rao BK (2014) Methods and rates of dermoscopy usage: a cross-sectional survey of US dermatologists stratified by years in practice. J Am Acad Dermatol 71:393–395. https://doi.org/10.1016/j.jaad.2014.03.048
Navarrete-Dechent C, Dusza SW, Liopyris K, Marghoob AA, Halpern AC, Marchetti MA (2018) Automated dermatological diagnosis: hype or reality? J Invest Dermatol. https://doi.org/10.1016/j.jid.2018.04.040
Negin BP, Riedel E, Oliveria SA, Berwick M, Coit DG, Brady MS (2003) Symptoms and signs of primary melanoma: important indicators of Breslow depth. Cancer 98:344–348. https://doi.org/10.1002/cncr.11513
Ng JC, Swain S, Dowling JP, Wolfe R, Simpson P, Kelly JW (2010) The impact of partial biopsy on histopathologic diagnosis of cutaneous melanoma: experience of an Australian tertiary referral service. Arch Dermatol 146:234–239. https://doi.org/10.1001/archdermatol.2010.14
Norman G (2006) Building on experience–the development of clinical reasoning. N Engl J Med 355: 2251–2252. https://doi.org/10.1056/NEJMe068134
Okamoto N et al (2014) A melanocyte – cmelanoma precursor niche in sweat glands of volar skin. Pigment Cell Melanoma Res 27:1039–1050. https://doi.org/10.1111/pcmr.12297
Oliveria SA, Christos PJ, Halpern AC, Fine JA, Barnhill RL, Berwick M (1999) Patient knowledge, awareness, and delay in seeking medical attention for malignant melanoma. J Clin Epidemiol 52:1111–1116
Olsen CM et al (2018a) Risk stratification for melanoma: models derived and validated in a purpose-designed prospective cohort. J Natl Cancer Inst. https://doi.org/10.1093/jnci/djy023
Olsen J, Holmes J, Jemec GB (2018b) Advances in optical coherence tomography in dermatology-a review. J Biomed Opt 23:1–10. https://doi.org/10.1117/1.jbo.23.4.040901
Palicka GA, Rhodes AR (2010) Acral melanocytic nevi: prevalence and distribution of gross morphologic features in white and black adults. Arch Dermatol 146:1085–1094. https://doi.org/10.1001/archdermatol.2010.299
Pan Y, Adler NR, Wolfe R, McLean CA, Kelly JW (2017) Nodular melanoma is less likely than superficial spreading melanoma to be histologically associated with a naevus. Med J Aust 207:333–338
Patrick RJ, Fenske NA, Messina JL (2007) Primary mucosal melanoma. J Am Acad Dermatol 56:828–834. https://doi.org/10.1016/j.jaad.2006.06.017
Pellacani G, Pepe P, Casari A, Longo C (2014) Reflectance confocal microscopy as a second-level examination in skin oncology improves diagnostic accuracy and saves unnecessary excisions: a longitudinal prospective study. Br J Dermatol. https://doi.org/10.1111/bjd.13148
Phan A, Touzet S, Dalle S, Ronger-Savle S, Balme B, Thomas L (2007) Acral lentiginous melanoma: histopathological prognostic features of 121 cases. Br J Dermatol 157:311–318. https://doi.org/10.1111/j.1365-2133.2007.08031.x
Phan A, Dalle S, Touzet S, Ronger-Savle S, Balme B, Thomas L (2010) Dermoscopic features of acral lentiginous melanoma in a large series of 110 cases in a white population. Br J Dermatol 162:765–771. https://doi.org/10.1111/j.1365-2133.2009.09594.x
Posther KE, Selim MA, Mosca PJ, Stanley WE, Johnson JL, Tyler DS, Seigler HF (2006) Histopathologic characteristics, recurrence patterns, and survival of 129 patients with desmoplastic melanoma. Ann Surg Oncol 13:728–739. https://doi.org/10.1245/aso.2006.03.091
Puig S et al (2005) Role of the CDKN2A locus in patients with multiple primary melanomas. J Clin Oncol 23:3043–3051. https://doi.org/10.1200/jco.2005.08.034
Rayner JE, Laino AM, Nufer KL, Adams L, Raphael AP, Menzies SW, Soyer HP (2018) Clinical perspective of 3D Total body photography for early detection and screening of melanoma. Front Med 5:152. https://doi.org/10.3389/fmed.2018.00152
Read J, Wadt KA, Hayward NK (2016) Melanoma genetics. J Med Genet 53:1–14. https://doi.org/10.1136/jmedgenet-2015-103150
Reintgen DS, McCarty KM Jr, Cox E, Seigler HF (1982) Malignant melanoma in black American and white American populations. A comparative review. JAMA 248:1856–1859
Revesz G (1985) Conspicuity and uncertainty in the radiographic detection of lesions. Radiology 154:625–628. https://doi.org/10.1148/radiology.154.3.3969462
Revesz G, Kundel HL (1977) Psychophysical studies of detection errors in chest radiology. Radiology 123:559–562. https://doi.org/10.1148/123.3.559
Reyes BA, Robins P (1988) Wood’s lamp and surgical margins in malignant melanoma in situ. J Dermatol Surg Oncol 14:22
Rhodes AR (1998) Intervention strategy to prevent lethal cutaneous melanoma: use of dermatologic photography to aid surveillance of high-risk persons. J Am Acad Dermatol 39:262–267
Richard MA et al (2000a) Delays in diagnosis and melanoma prognosis (I): the role of patients. Int J Cancer 89:271–279
Richard MA et al (2000b) Delays in diagnosis and melanoma prognosis (II): the role of doctors. Int J Cancer 89:280–285
Rigel DS, Carucci JA (2000) Malignant melanoma: prevention, early detection, and treatment in the 21st century. CA Cancer J Clin 50:215–236; quiz 237–240
Rocha L, Menzies SW, Lo S, Avramidis M, Khoury R, Jackett L, Guitera P (2017) Analysis of an electrical impedance spectroscopy system in short-term digital dermoscopy imaging of melanocytic lesions. Br J Dermatol 177:1432–1438. https://doi.org/10.1111/bjd.15595
Rogers RS, Gibson LE (1997) Mucosal, genital, and unusual clinical variants of melanoma. Mayo Clin Proc 72:362–366. https://doi.org/10.1016/s0025-6196(11)63338-7
Rosen T (2006) Acral lentiginous melanoma misdiagnosed as verruca plantaris: a case report. Dermatol Online J 12:3
Rowe CJ, Law MH, Palmer JM, MacGregor S, Hayward NK, Khosrotehrani K (2015) Survival outcomes in patients with multiple primary melanomas. J Eur Acad Dermatol Venereol 29:2120–2127. https://doi.org/10.1111/jdv.13144
Saida T (2000) Malignant melanoma on the sole: how to detect the early lesions efficiently. Pigment Cell Res 13(Suppl 8):135–139
Saida T, Yoshida N, Ikegawa S, Ishihara K, Nakajima T (1990) Clinical guidelines for the early detection of plantar malignant melanoma. J Am Acad Dermatol 23:37–40
Saida T, Ishihara Y, Tokuda Y (1993) Effective detection of plantar malignant melanoma. Int J Dermatol 32:722–725
Salerni G et al (2012) Benefits of total body photography and digital dermatoscopy (“two-step method of digital follow-up”) in the early diagnosis of melanoma in patients at high risk for melanoma. J Am Acad Dermatol 67:e17–e27. https://doi.org/10.1016/j.jaad.2011.04.008
Schmid-Wendtner MH, Baumert J, Stange J, Volkenandt M (2002) Delay in the diagnosis of cutaneous melanoma: an analysis of 233 patients. Melanoma Res 12:389–394
Schmoeckel C, Wildi G, Schafer T (2007) Spitz nevus versus malignant melanoma: spitz nevi predominate on the thighs in patients younger than 40 years of age, melanomas on the trunk in patients 40 years of age or older. J Am Acad Dermatol 56:753–758. https://doi.org/10.1016/j.jaad.2006.11.037
Scolyer RA, Thompson JF (2005) Desmoplastic melanoma: a heterogeneous entity in which subclassification as “pure” or “mixed” may have important prognostic significance. Ann Surg Oncol 12:197–199. https://doi.org/10.1245/aso.2005.12.914
Scope A et al (2006) Predominant dermoscopic patterns observed among nevi. J Cutan Med Surg 10:170–174. https://doi.org/10.2310/7750.2006.00045
Scope A et al (2008) The “ugly duckling” sign: agreement between observers. Arch Dermatol 144:58–64. https://doi.org/10.1001/archdermatol.2007.15
Serarslan G, Akcaly C, Atik E (2004) Acral lentiginous melanoma misdiagnosed as tinea pedis: a case report. Int J Dermatol 43:37–38
Shaikh WR, Xiong M, Weinstock MA (2012) The contribution of nodular subtype to melanoma mortality in the United States, 1978 to 2007. Arch Dermatol 148:30–36. https://doi.org/10.1001/archdermatol.2011.264
SIAscopy (2018) https://medxhealth.com/en/ Accessed 8 January 2019
Somach SC, Taira JW, Pitha JV, Everett MA (1996) Pigmented lesions in actinically damaged skin. Histopathologic comparison of biopsy and excisional specimens. Arch Dermatol 132:1297–1302
Soon SL, Solomon AR Jr, Papadopoulos D, Murray DR, McAlpine B, Washington CV (2003) Acral lentiginous melanoma mimicking benign disease: the Emory experience. J Am Acad Dermatol 48:183–188. https://doi.org/10.1067/mjd.2003.63
Stam-Posthuma JJ, van Duinen C, Scheffer E, Vink J, Bergman W (2001) Multiple primary melanomas. J Am Acad Dermatol 44:22–27
Stang A, Jockel KH (2016) Does skin cancer screening save lives? A detailed analysis of mortality time trends in Schleswig-Holstein and Germany. Cancer 122:432–437. https://doi.org/10.1002/cncr.29755
Stang A, Garbe C, Autier P, Jockel KH (2016) The many unanswered questions related to the German skin cancer screening programme. Eur J Cancer 64:83–88. https://doi.org/10.1016/j.ejca.2016.05.029
Stevens NG, Liff JM, Weiss NS (1990) Plantar melanoma: is the incidence of melanoma of the sole of the foot really higher in blacks than whites? Int J Cancer 45:691–693
Tacastacas JD et al (2014) Update on primary mucosal melanoma. J Am Acad Dermatol 71: 366–375. https://doi.org/10.1016/j.jaad.2014.03.031
Tejera-Vaquerizo A, Barrera-Vigo MV, Lopez-Navarro N, Herrera-Ceballos E (2010) Growth rate as a prognostic factor in localized invasive cutaneous melanoma. J Eur Acad Dermatol Venereol 24:147–154. https://doi.org/10.1111/j.1468-3083.2009.03367.x
Temoshok L, DiClemente RJ, Sweet DM, Blois MS, Sagebiel RW (1984) Factors related to patient delay in seeking medical attention for cutaneous malignant melanoma. Cancer 54:3048–3053
Thomas L, Tranchand P, Berard F, Secchi T, Colin C, Moulin G (1998) Semiological value of ABCDE criteria in the diagnosis of cutaneous pigmented tumors. Dermatology 197:11–17. https://doi.org/10.1159/000017969
Thomas NE et al (2007) Number of nevi and early-life ambient UV exposure are associated with BRAF-mutant melanoma. Cancer Epidemiol Biomark Prev 16:991–997. https://doi.org/10.1158/1055-9965.epi-06-1038
Thomas NE et al (2014) Comparison of clinicopathologic features and survival of Histopathologically Amelanotic and pigmented melanomas: a population-based study. JAMA Dermatol. https://doi.org/10.1001/jamadermatol.2014.1348
Titus-Ernstoff L, Perry AE, Spencer SK, Gibson J, Ding J, Cole B, Ernstoff MS (2006) Multiple primary melanoma: two-year results from a population-based study. Arch Dermatol 142:433–438. https://doi.org/10.1001/archderm.142.4.433
Tromme I et al (2012) Availability of digital dermoscopy in daily practice dramatically reduces the number of excised melanocytic lesions: results from an observational study. Br J Dermatol 167:778–786. https://doi.org/10.1111/j.1365-2133.2012.11042.x
Truong A, Strazzulla L, March J, Boucher KM, Nelson KC, Kim CC, Grossman D (2016) Reduction in nevus biopsies in patients monitored by total body photography. J Am Acad Dermatol 75:135–143.e135. https://doi.org/10.1016/j.jaad.2016.02.1152
Ulusal BG, Karatas O, Yildiz AC, Oztan Y (2003) Primary malignant melanoma of the maxillary gingiva. Dermatol Surg 29:304–307
Usher-Smith JA, Emery J, Kassianos AP, Walter FM (2014) Risk prediction models for melanoma: a systematic review. Cancer Epidemiol Biomark Prev 23:1450–1463. https://doi.org/10.1158/1055-9965.epi-14-0295
Varey AHR et al (2017) Neurotropic melanoma: an analysis of the clinicopathological features, management strategies and survival outcomes for 671 patients treated at a tertiary referral center. Mod Pathol 30:1538–1550. https://doi.org/10.1038/modpathol.2017.76
VECTRA WB360 3D Whole Body Imaging System. http://www.canfieldsci.com/imaging-systems/vectra-wb360-imaging-system/. Accessed 29 Dec 2015
Vestergaard ME, Macaskill P, Holt PE, Menzies SW (2008) Dermoscopy compared with naked eye examination for the diagnosis of primary melanoma: a meta-analysis of studies performed in a clinical setting. Br J Dermatol 159:669–676. https://doi.org/10.1111/j.1365-2133.2008.08713.x
Vuong K, McGeechan K, Armstrong BK, Cust AE (2014) Risk prediction models for incident primary cutaneous melanoma: a systematic review. JAMA Dermatol 150:434–444. https://doi.org/10.1001/jamadermatol.2013.8890
Vyas R, Thompson CL, Zargar H, Selph J, Gerstenblith MR (2016) Epidemiology of genitourinary melanoma in the United States: 1992 through 2012. J Am Acad Dermatol 75:144–150. https://doi.org/10.1016/j.jaad.2015.10.015
Walter FM et al (2012) Effect of adding a diagnostic aid to best practice to manage suspicious pigmented lesions in primary care: randomised controlled trial. BMJ 345:e4110. https://doi.org/10.1136/bmj.e4110
Wang Y, Zhao Y, Ma S (2016) Racial differences in six major subtypes of melanoma: descriptive epidemiology. BMC Cancer 16:691. https://doi.org/10.1186/s12885-016-2747-6
Warycha MA et al (2008) Changes in the presentation of nodular and superficial spreading melanomas over 35 years. Cancer 113:3341–3348. https://doi.org/10.1002/cncr.23955
Watts CG, Dieng M, Morton RL, Mann GJ, Menzies SW, Cust AE (2015) Clinical practice guidelines for identification, screening and follow-up of individuals at high risk of primary cutaneous melanoma: a systematic review. Br J Dermatol 172:33–47. https://doi.org/10.1111/bjd.13403
Watts CG, Cust AE, Menzies SW, Mann GJ, Morton RL (2017) Cost-effectiveness of skin surveillance through a specialized Clinic for Patients at high risk of melanoma. J Clin Oncol 35:63–71. https://doi.org/10.1200/jco.2016.68.4308
Weinstock MA (2006) ABCD, ABCDE, and ABCCCDEEEEFNU. Arch Dermatol 142:528. https://doi.org/10.1001/archderm.142.4.528-a
Weinstock MA, Brodsky GL (1998) Bias in the assessment of family history of melanoma and its association with dysplastic nevi in a case-control study. J Clin Epidemiol 51:1299–1303
White WL, Hitchcock MG (1998) Dying dogma: the pathological diagnosis of epidermotropic metastatic malignant melanoma. Semin Diagn Pathol 15:176–188
Whited JD, Grichnik JM (1998) The rational clinical examination. Does this patient have a mole or a melanoma? JAMA 279:696–701
Whiteman DC, Watt P, Purdie DM, Hughes MC, Hayward NK, Green AC (2003) Melanocytic nevi, solar keratoses, and divergent pathways to cutaneous melanoma. J Natl Cancer Inst 95:806–812
Wiesner T, Kutzner H, Cerroni L, Mihm MC Jr, Busam KJ, Murali R (2016) Genomic aberrations in spitzoid melanocytic tumours and their implications for diagnosis, prognosis and therapy. Pathology 48:113–131. https://doi.org/10.1016/j.pathol.2015.12.007
Wu X, Oliveria SA, Yagerman S, Chen L, DeFazio J, Braun R, Marghoob AA (2015) Feasibility and efficacy of patient-initiated Mobile Teledermoscopy for short-term monitoring of clinically atypical nevi. JAMA Dermatol 151:489–496. https://doi.org/10.1001/jamadermatol.2014.3837
Wu S, Cho E, Li WQ, Qureshi AA (2017) History of keratinocyte carcinoma and risk of melanoma: a prospective cohort study. J Natl Cancer Inst 109. https://doi.org/10.1093/jnci/djw268
Yagerman SE, Chen L, Jaimes N, Dusza SW, Halpern AC, Marghoob A (2014) ‘Do UC the melanoma?’ Recognising the importance of different lesions displaying unevenness or having a history of change for early melanoma detection. Australas J Dermatol 55:119–124. https://doi.org/10.1111/ajd.12143
Yelamos O et al (2017) Correlation of handheld reflectance confocal microscopy with radial video Mosaicing for margin mapping of Lentigo Maligna and Lentigo Maligna melanoma. JAMA Dermatol 153:1278–1284. https://doi.org/10.1001/jamadermatol.2017.3114
Yokoyama S et al (2011) A novel recurrent mutation in MITF predisposes to familial and sporadic melanoma. Nature 480:99–103. https://doi.org/10.1038/nature10630
Yu C, Yang S, Kim W, Jung J, Chung KY, Lee SW, Oh B (2018) Acral melanoma detection using a convolutional neural network for dermoscopy images. PLoS One 13:e0193321. https://doi.org/10.1371/journal.pone.0193321
Zabel RJ, Vinson RP, McCollough ML (2000) Malignant melanoma arising in a seborrheic keratosis. J Am Acad Dermatol 42:831–833
Zalaudek I (2006) Man sees only what he knows. Arch Dermatol 142:530. https://doi.org/10.1001/archderm.142.4.530-a
Zalaudek I et al (2008) Three roots of melanoma. Arch Dermatol 144:1375–1379. https://doi.org/10.1001/archderm.144.10.1375
Zhang J et al (2016) Factors associated with biopsy site identification, postponement of surgery, and patient confidence in a dermatologic surgery practice. J Am Acad Dermatol 74:1185–1193. https://doi.org/10.1016/j.jaad.2015.12.019
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Halpern, A.C., Marghoob, A.A., Sober, A.J., Mar, V., Marchetti, M.A. (2020). Clinical Presentations of Melanoma. In: Balch, C., et al. Cutaneous Melanoma. Springer, Cham. https://doi.org/10.1007/978-3-030-05070-2_9
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