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Dynamics of Cerebrospinal Fluid: From Theoretical Models to Clinical Applications

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Biomechanics of the Brain

Part of the book series: Biological and Medical Physics, Biomedical Engineering ((BIOMEDICAL))

Abstract

Quantitative assessment of CSF dynamics may support clinical intuition with a description of the CSF circulatory and compensatory dysfunction, particularly when both clinical and imaging evidence is subtle and ambiguous. For normal pressure hydrocephalus (NPH), the consensus regarding the use of physiological parameters in conjunction with clinical and imaging information is still uncertain, despite guidelines for the management of NPH published some time ago. Main trouble was that they have never been based on sufficiently hard clinical and experimental evidence. Current range of clinical applications for CSF dynamics testing includes hydrocephalus, idiopathic intracranial hypertension, craniosynostosis, traumatic brain injury – in the latter useful in differentiating post-traumatic hydrocephalus from atrophy and assessing CSF pathways following decompressive craniectomy. From the viewpoint of clinical diagnosis and modelling, three techniques are particularly useful: infusion test, overnight ICP monitoring, and non-invasive detection of CSF movement using phase-coded MRI. These techniques are described and discussed.

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Authors and Affiliations

  1. Neurosurgical Unit, University of Cambridge, Department of Clinical Neurosciences, Cambridge, UK

    Laurent Geregele, Afroditi Lalou, Piotr Smielewski, John D. Pickard, Marek Czosnyka & Zofia Czosnyka

  2. Department of Intensive Care, Ramsay Générale de Santé, Hôpital privé de la Loire, Saint Etienne, France

    Laurent Geregele

  3. Department of Imaging and Biophysics, University Hospital Amiens, Amiens, France

    Olivier Baledent

  4. Department of Neurosurgery B, Neurological Hospital Wertheimer, University of Lyon, Lyon, France

    Romain Manet

  5. Department of Neurosurgery and Traumatology, Public Pediatric Teaching Clinical Hospital, Medical University of Warsaw, Warsaw, Poland

    Slawomir Barszcz

  6. Institute of Biomedical Engineering and Instrumentation, Wroclaw University of Technology, Wrocław, Poland

    Magdalena Kasprowicz

  7. Institute of Electronic Systems, Warsaw Univeristy of Technology, Warsaw, Poland

    Marek Czosnyka

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    Karol Miller

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Geregele, L. et al. (2019). Dynamics of Cerebrospinal Fluid: From Theoretical Models to Clinical Applications. In: Miller, K. (eds) Biomechanics of the Brain. Biological and Medical Physics, Biomedical Engineering. Springer, Cham. https://doi.org/10.1007/978-3-030-04996-6_8

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