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The Microbiome Associated with Lung Cancer

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Microbiome and Cancer

Part of the book series: Current Cancer Research ((CUCR))

Abstract

Recent studies on the lung microbiome have renewed the interest in understanding the relationship between microbes and lung diseases. The complex symbiotic relationship between microbiota and host have led researchers to postulate that many host diseases, including cancer, are directly associated with the commensal microbiome. Evidence suggests that the lung microbiome may contribute to local host inflammatory changes, which include the Th17 response. In lung cancer, studies suggest that lung dysbiosis may affect different stages of carcinogenesis. In this article, we review the latest knowledge gained from microbiome studies and explore possible mechanisms of microbe-host interaction that may have relevance to lung cancer pathogenesis.

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Acknowledgement

Sources of support: This work was supported by K23 AI102970 (L.N.S.), DOD grant, A Breath of Hope Lung Foundation. Conflict of interest: No conflicts of interest are reported by any authors.

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  1. Division of Pulmonary, Critical Care and Sleep Medicine, New York University School of Medicine, New York, NY, USA

    Jun-Chieh J. Tsay, Vivek Murthy & Leopoldo N. Segal

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  1. Jun-Chieh J. Tsay
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  2. Vivek Murthy
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  3. Leopoldo N. Segal
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  1. Department of Otorhinolaryngology – Head and Neck Surgery Abramson Comprehensive Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA

    Erle S. Robertson

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Tsay, JC.J., Murthy, V., Segal, L.N. (2019). The Microbiome Associated with Lung Cancer. In: Robertson, E. (eds) Microbiome and Cancer. Current Cancer Research. Humana Press, Cham. https://doi.org/10.1007/978-3-030-04155-7_8

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  • DOI: https://doi.org/10.1007/978-3-030-04155-7_8

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