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Primary Hyperparathyroidism

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Metabolic Bone Diseases

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Abstract

Primary hyperparathyroidism (PHPT) is a major cause of hypercalcemia in the population. Although many cases of PHPT today present with mild symptoms or are asymptomatic at time of diagnosis, we describe a case of a 22-year-old man who presented with overt skeletal manifestations of PHPT. The major clinical manifestations of primary hyperparathyroidism are reviewed including skeletal, renal, neuropsychiatric, gastrointestinal, and cardiovascular manifestations. Patients suspected of having PHPT require a workup to exclude secondary causes of elevated parathyroid hormone such as vitamin D deficiency, familial hypocalciuric hypercalcemia, and medication side effects such as thiazides, lithium, bisphosphonates, and denosumab. The management of PHPT is reviewed, including indications for parathyroidectomy as well as when medical therapy, such as cinacalcet, may be indicated. This chapter provides a detailed description of the workup and management of PHPT that can be used by the practicing endocrinologist.

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Authors and Affiliations

  1. Division of Endocrinology, Metabolism and Molecular Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA

    Clare O’Connor, Joshua A. Levine & Allison Hahr

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  1. Clare O’Connor
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  2. Joshua A. Levine
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  3. Allison Hahr
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Correspondence to Allison Hahr .

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Editors and Affiliations

  1. Division of Endocrinology and Metabolism, Loyola University Medical Center, Maywood, IL, USA

    Pauline M. Camacho

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O’Connor, C., Levine, J.A., Hahr, A. (2019). Primary Hyperparathyroidism. In: Camacho, P. (eds) Metabolic Bone Diseases. Springer, Cham. https://doi.org/10.1007/978-3-030-03694-2_2

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  • DOI: https://doi.org/10.1007/978-3-030-03694-2_2

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-03693-5

  • Online ISBN: 978-3-030-03694-2

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