Abstract
The terms cosmeceutical and evidence-based may not belong in the same phrase. Cosmeceuticals are considered by many scientists to represent fluff without stuff, and indeed the reader may come to a similar conclusion at the end of this chapter. Nevertheless, it is worthwhile to examine the state of the science for cosmeceuticals as they represent an ever-expanding field in dermatology with perhaps much yet unrealized promise. Cosmeceuticals extend beyond cosmetics to enhance skin functioning, usually aiming to return the skin to a more youthful state. For example, wrinkle-reducing moisturizers, antioxidant serums, and skin-lightening salves all fall into this category. Cosmeceuticals are somewhat confusing, however, as both prescription and over-the-counter (OTC) products have been labeled by this term. Drug cosmeceuticals include topical retinoids for improving dermal collagen production, topical minoxidil for enhanced scalp hair growth, and eflornithine for facial hair growth reduction. These products will not be discussed, as they are not available to the consumer except by prescription. The second category of cosmeceuticals includes OTC drugs, such as sunscreens and antiperspirants. These also are outside the realm of this chapter. The discussion will focus on cosmeceuticals that are topically applied for the purpose of improving skin appearance.
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References
Hussein G, Sankawa U, Goto H, Matsumoto K, Watanabe H. Astaxanthin, a carotenoid with potential in human health and nutrition. J Nat Prod. 2006;69(3):443–9.
Karppi J, Rissanen TH, Nyyssonen K, Kaikkonen J, Olsson AG, Voutilaninen S, et al. Effects of astaxanthin supplementation of lipid peroxidation. Int J Vitam Nutr Res. 2007;77(1):3–11.
Seki T. Effects of astaxanthin on human skin. Frag J. 2001;12:98–103.
Higuera-Ciapara I, Felix-Valenzuela L, Goycoolea FM. Astaxanthin: a review of its chemistry and applications. Crit Rev Food Sci Nutr. 2006;46(2):185–96.
Tso MO, Lam TT. Method of retarding and ameliorating central nervous system and eye damage. US Patent #5527533. Board of trustees of the University of Illinois, USA; 1996.
Pashkow FJ, Watumull DG, Campbell CL. Astaxanthin: a novel potential treatment for oxidative stress and inflammation in cardiovascular disease. Am J Cardiol. 2008;101(10A):58D–68.
Alves-Rodrigues A, Shao A. The science behind lutein. Toxicol Lett. 2004;150(1):57–83.
Barclay L. Lutein improves visual function in age-related macular degeneration. Medscape Medical News. http://www.medscape.com. Accessed 13 June 2011.
Hahn A, Mang B. Lutein and eye health-current state of discussion. Med Monatsschr Pharm. 2008;31(8):299–308.
Semba RD, Dagnelie G. Are lutein and zeaxanthin conditionally essential nutrients for eye health? Med Hypotheses. 2003;61(4):465–72.
American Association for Cancer Research Newsletter May 17; 2007, “No Magic Tomato?”.
Kligman LH, Do CH, Kligman AM. Topical retinoic acid enhances the repair of ultraviolet damaged dermal connective tissue. Connect Tissue Res. 1984;12:139–50.
Goodman DS. Vitamin A and retinoids in health and disease. N Engl J Med. 1984;310(16):1023–31.
Noy N. Interactions of retinoids with lipid bilayers and with membranes. In: Livrea MA, Packer L, editors. Retinoids. New York: Marcel Dekker; 1993. p. 17–27.
Duell EA, Derguini F, Kang S, Elder JT, Voorhees JJ. Extraction of human epidermis treated with retinol yields retro-retinoids in addition to free retinol and retinyl esters. J Invest Dermatol. 1996;107:178–82.
Kafi R, Swak HS, Schumacher WE, Cho S, Hanft VN, Hamilton TA, et al. Improvement of naturally aged skin with vitamin A (retinol). Arch Dermatol. 2007;143(5):606–12.
Hruza GJ. Retinol benefits naturally aged skin. J Watch Dermatol. 2007;6(6)
Arct J, Pytokowska K. Flavonoids as components of biologically active cosmeceuticals. Clin Dermatol. 2008;26:347–57.
Glazier MG, Bowman MA. A review of the evidence for the use of phytoestrogens as a replacement for traditional estrogen replacement therapy. Arch Intern Med. 2001;161:1161–72.
Friedman M, Brandon DL. Nutritional and health benefits of soy proteins. J Agric Food Chem. 2001;49(3):1069–86.
Sakai T, Kogiso M. Soy isoflavones and immunity. J Med Investig. 2008;55(3–4):167–73.
Sarkar FH, Li Y. Soy isoflavones and cancer prevention. Cancer Investig. 2003;21(5):817–8.
Omoni AO, Aluko RE. Soybean foods and their benefits: potential mechanisms of action. Nutr Rev. 2005;63(8):272–83.
Maheux R, Naud F, Rioux M, Grenier R, Lemay A, Guy J, et al. A randomized, double-blind, placebo-controlled study on the effect of conjugated estrogens on skin thickness. Am J Obstet Gynecol. 1994;170:642–9.
Wiseman H, O’Reilly JD, Adlercreutz H, Mallet AL, Bowey EA, Rowland IR, et al. Isoflavone phytoestrogens consumed in soy decrease F-2-isoprostane concentrations and increase resistance of low-density lipoprotein to oxidation in humans. Am J Clin Nutr. 2000;72:395–400.
Chen N, Scarpa R, Zhang L, Seiberg M, Lin CB. Nondenatured soy extracts reduce UVB-induced skin damage via multiple mechanisms. Photochem Photobiol. 2008;84(6):1551–9.
Hatcher H, Planalp R, Cho J, Torti FM, Torti SV. Curcumin: from ancient medicine to current clinical trials. Cell Mol Life Sci. 2008;65(11):1631–52.
Jagetia GC, Aggarwal BB. “Spicing up” of the immune system by curcumin. J Clin Immunol. 2007;27(1):19–35.
Egan ME, Pearson M, Weiner SA, Rajendran V, Rubin D, glockner-Pagel J, et al. Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects. Science. 2004;304(5670):600–2.
Kunnumakkara AB, Anand P, Aggarwal BB. Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins. Cancer Lett. 2008;269(2):199–225.
Katiyar SK, Korman NJ, Mukhtar H, Agarwal R. Protective effects of silymarin against photocarcinogenesis in a mouse skin model. J Natl Cancer Inst. 1997;89:556–66.
Katiyar SK. Silymarin and skin cancer prevention: anti-inflammatory, antioxidant and immunomodulatory effects (review). Int J Oncol. 2005;26(1):169–76.
Chatterjee L, Agarwal R, Mukhtar H. Ultraviolet B radiation-induced DNA lesions in mouse epidermis: an assessment sing a novel 32P-postlabeling technique. Biochem Biophys Res Commun. 1996;229:590–5.
Toklu HZ, Tunali-Akbay T, Erkanli G, Yuksel M, Ercan F, Sener G. Silymarin, the antioxidant component of Silybum marianum, protects against burn-induced oxidative skin injury. Burn. 2007;33(7):908–16.
Berardesca E, Cameli N, Cavallotti C, Levy JL, Pierard GE, de Paoli Ambrosi G. Combined effects of silymarin and methylsulfonylmethane in the management of rosacea: clinical and instrumental evaluation. J Cosmet Dermatol. 2008;7(1):8–14.
Pycnogenol. Drug information online: http://www.drugs.com/npp/pycnogenol.html. Accessed 7 Dec 2008.
Devaraj S, Vega-Lopez S, Kaul N, Schonlau F, Rohdewald P, Jialal I. Supplementation with a pine bark extract rich in polyphenols increases plasma antioxidant capacity and alters the plasma lipoprotein profile. Lipids. 2002;37:931–4.
Cesarone MR, Belcaro G, Rohdewald P, Pellegrini L, Ledda A, Vinciguerra G, et al. Improvement of diabetic microangiopathy with pycnogenol: a prospective, controlled study. Angiology. 2006;57(4):431–6.
Vinciguerra G, Belcaro G, Cesarone MR, Rohdewald P, Stuard S, Ricci A, et al. Cramps and muscular pain: prevention with pycnogenol in normal subjects, venous patients, athletes, claudicants and in diabetic microangiopathy. Angiology. 2006;57(3):331–9.
Cossins E, Lee R, Packer L. ESR studies of vitamin C regeneration, order of reactivity of natural source phytochemical preparations. Biochem Mol Biol Int. 1998;45:583–98.
Schonlau F. The cosmetic pycnogenol. J Appl Cosmetol. 2002;20:241–6.
Kim YJ, Kang KS, Yokozawa T. The anti-melanogenic effect of pycnogenol by its anti-oxidative actions. Food Chem Toxicol. 2008;46(7):2466–71.
Rona C, Vailati F, Berardesca D. The cosmetic treatment of wrinkles. J Cosmet Dermatol. 2004;3(1):26–34.
Joyeux M, Lobstein A, Anton R, Mortier F. Comparative antilipoperoxidant, antinecrotic and scavenging properties of terpenes and biflavones from Ginkgo and some flavonoids. Planta Med. 1995;61:126–9.
Kim SJ, Lim MH, Chun IK, Won YH. Effects of flavonoids of Ginkgo biloba on proliferation of human skin fibroblast. Skin Pharmacol. 1997;10:200–5.
Hsu S. Green tea and the skin. J Am Acad Dermatol. 2005;52:1049–59.
US FDA/CFSAN Letter Responding to Health Claim Petition dated January 27, 2004: Green tea and Reduced Risk of Cancer Health Claim (Docket number 2004Q-0083).
US FDA/CFSAN Qualified Health Claims: Letter of Denial Green Tea and Reduced Risk of Cardiovascular Disease (Docket number 2005Q-0297).
Katiyar SK, Elmets CA. Green tea and skin. Arch Dermatol. 2000;136:989–94.
Geria NM. Green, black or white, it fits beauty to a “t”. HAPPI. 2006:46–50.
Abstract 6. J Am Coll Nutr. 2006;25(5).
Abstract 7. J Am Coll Nutr. 2006;25(5).
Chui AD, Chan JL, Kern DG, et al. Double-blinded, placebo-controlled trial of green tea extracts in the clinical and histologic appearance of photoaging skin. Dermatol Surg. 2005;31(7 Pt 2):855–60.
Katiyar SK, Elmets CA, Agarwal R, et al. Protection against ultraviolet-B radiation-induced local and systemic suppression of contact hypersensitivity and edema responses in C3H/HeN mice by green tea polyphenols. Photochem Photobiol. 1995;62:855–61.
Elmets CA, Singh D, Tubesing K, Matsui MS, Katiyar SK, Mukhtar H. Green tea polyphenols as chemopreventive agents against cutaneous photodamage. J Am Acad Dermatol. 2001;44:425–32.
Katiyar SK, Afaq F, Perez A, Mukhtar H. Green tea polyphenol treatment to human skin prevents formation of ultraviolet light B-induced pyrimidine dimers in DNA. Clin Cancer Res. 2000;6:3864–9.
Ahmad N, Mukhtar H. Cutaneous photochemoprotection by green tea. A brief review. Skin Pharmacol Appl Ski Physiol. 2001;14:69–76.
Mukhtar H, Katiyar SK, Agarwal R. Green tea and skin – anticarcinogenic effects. J Invest Dermatol. 1994;102:3–7.
Jurenka JS. Therapeutic applications of pomegranate (Punica granatum L.): a review. Altern Med Rev. 2008;13(2):128–44.
Pacheco-Palencia LA, Noratto G, Hingorani L, Talcott ST, Mertens-Talcott SU. Protective effects of standardized pomegranate (Punica granatum L.) polyphenolic extract in ultraviolet-irradiated human skin fibroblasts. J Agric Food Chem. 2008;56(18):8434–41.
Aviram M, Rosenblat M, Gaitini D, Nitecki S, Hoffman A, Dornfeld L, et al. Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness, blood pressure and LDL oxidation. Clin Nutr. 2004;23(3):423–33.
Aviram M, Dornfeld L, Rosenblat M, et al. Pomegranate juice consumption reduces oxidative stress, atherogenic modifications to LDL, and platelet aggregation: studies in humans and in atherosclerotic apolipoprotein e-deficient mice. Am J Clin Nutr. 2000;71:1062–76.
Esmaillzadeh A, Tahbaz F, Gaieni I, Alavi-Majd H, Azadbakht L. Concentrated pomegranate juice improves profiles in diabetic patients with hyperlipidemia. J Med Food. 2004;7(3):305–8.
McKeown E. Aloe vera. Cosmet Toilet. 1987;102:64–5.
Waller T. Aloe vera. Cosmet Toilet. 1992;107:53–4.
Maenthaisong R, Chaiyakunapruk N, Niruntraporn S, Kongkaew C. The efficacy of aloe vera for burn wound healing: a systematic review. Burns. 2007;33(6):713–8.
Orafidiya LO, Agbani EO, Oyedele AO, Babalola OO, Onayemi O, Aiyedun FF. The effect of aloe vera gel on the anti-acne properties of the essential oil of Ocimum gratissimum Linn leaf-a preliminary clinical investigation. Int J Aromather. 2004;14(1):15–21.
Puvabanditsin P, Vongtongsri R. Efficacy of aloe vera cream in prevention and treatment of sunburn and suntan. J Med Assoc Thail. 2005;88(Suppl 4):S173–6.
Reuter J, Jocher A, Stump J, Grossjohann B, Franke G, Sshempp CM. Investigation of the anti-inflammatory potential of aloe vera gel (97.5%) in the ultraviolet erythema test. Skin Pharmacol Physiol. 2008;21(2):106–10.
Hoppe U, Bergemann J, Diembeck W, Ennen J, Gohla S, Harris I, et al. Coenzyme Q10, a cutaneous antioxidant and energizer. Biofactors. 1999;9(2–4):371–8.
Blatt T, Mundt C, Mummert C, Maksiuk T, Wolber R, Keyhani R, et al. Modulation of oxidative stresses in human aging skin. Z Gerontol Geriatr. 1999;32(2):83–8.
Sohal RS, Kamzalov S, Sumien N, Ferguson M, Rebrin I, Heinrich KR, et al. Effect of coenzyme Q10 intake on endogenous coenzyme Q content, mitochondrial electron transport chain, antioxidant defenses, and life span of mice. Free Radic Biol Med. 2006;40(3):480–7.
Passi S, DePita O, Grandinetti M, Simotti C, Littarru GP. The combined use of oral and topical lipophilic antioxidants increases their levels both in sebum and stratum corneum. Biofactors. 2003;18(1–4):289–97.
Fuller B, Smith D, Howerton A, Kern D. Anti-inflammatory effects of coQ10 and colorless carotenoids. J Cosmet Dermatol. 2006;5(1):30–8.
Espinal-Perez LE, Moncada B, Castanedo-Cazares JP. A double blind randomized trial of 5% ascorbic acid vs. 4% hydroquinone in melasma. Int J Dermatol. 2004;43(8):604–7.
Amer M, Metwalli M. Topical liquiritin improves melasma. Int J Dermatol. 2000;39(4):299–301.
Beitner H. Randomized, placebo-controlled, double blind study on the clinical efficacy of a cream containing 5% alpha-lipoic acid related to photoageing of facial skin. Br J Dermatol. 2003;149(4):841–9.
Lim JT. Treatment of melasma using kojic acid in a gel containing hydroquinone and glycolic acid. Dermatol Surg. 1999;25:282–4.
Garcia A, Fulton JE Jr. The combination of glycolic acid and hydroquinone or kojic acid for the treatment of melasma and related conditions. Dermatol Surg. 1996;22(5):443–7.
Choi S, Lee SK, Kim JE, et al. Aloesin inhibits hyperpigmentation induced by UV radiation. Clin Exp Dermatol. 2002;27:513–5.
Jones K, Hughes J, Hong M, et al. Modulation of melanogenesis by aloesin: a competitive inhibitor of tyrosinase. Pigment Cell Res. 2002;15:335–40.
Wang Z, Li X, Yang Z, He X, Tu J, Zhang T. Effects of aloesin on melanogenesis in pigmented skin equivalents. Int J Cosmet Sci. 2008;30(2):121–30.
Hori I, Nihei K, Kubo I. Structural criteria for depigmenting mechanism of arbutin. Phytother Res. 2004;18:475–9.
Jun SY, Park KM, Choi KW, Jang MK, Kang HY, Lee SH, et al. Inhibitory effects of arbutin-beta-glycosides synthesized from enzymatic transglycosylation for melanogenesis. Biotechnol Lett. 2008;30(4):743–8.
Fitzpatrick RE, Rostan EF. Reversal of photodamage with topical growth factors: a pilot study. J Cosmet Laser Ther. 2003;5:25–34.
Mehta RC, Fitzpatrick RE. Endogenous growth factors as cosmeceuticals. Dermatol Ther. 2007;20(5):350–9.
Atkin DH, Trookman NS, Rizer RL, Schreck LE, Ho ET, Gotz V, Ford RO, Mehta RC. Combination of physiologically balanced growth factors with antioxidants for reversal of facial photodamage. J Cosmet Laser Ther. 2010;12(1):14–20.
Adair JH, Parette MP, Altinoglu EI, Kester M. Nanoparticle alternatives for drug delivery. ACS Nano. 2010;4(9):4967–70.
Kellar RS, Hubka M, Rheins LA, et al. Hypoxic conditioned culture medium from fibroblasts grown under embryonic-like conditions supports healing following post-laser resurfacing. J Cosmet Dermatol. 2009;8:190–6.
Zimber MP, Mansbridge JN, Taylor M, et al. Human cell-conditioned media produced under embryonic-like conditions result in improved healing time after laser resurfacing. Aesthet Plast Surg. 2012;36:431–7.
Mansbridge JN, Liu K, Pinney RE, Patch R, Ratcliffe A, Naughton GK. Growth factors secreted by fibroblasts: role in healing diabetic foot ulcers. Diabetes Obes Metab. 1999;1:265–79.
Bruce S, Karnik J, Dryer L, Burkholder D. Anti-aging proof of concept study: results and summary. J Drugs Dermatol. 2014;13:1074–81.
Gold MH, Biron J. A novel skin cream containing a mixture of human growth factors and cytokines for the treatment of adverse events associated with photodynamic therapy. J Drugs Dermatol. 2006;5:796–8.
Zettersten EM, Ghadially R, Feingold KR, Crumrine D, Elias PM. Optimal ratios of topical stratum corneum lipids improve barrier recovery in chronologically aged skin. J Am Acad Dermatol. 1997;37(3 Pt 1):403–8.
Vielhaber G, Lange S, Ley J, Koch O. N-palmitoyl-4-hydroxy-L-proline palmityl ester: a pseudoceramide that provides efficient skin barrier repair and protection. IFSCC Magazine. 2005;8.
Veraldi S, De Micheli P, Schianchi R, Lunardon L. Treatment of pruritus in mild-to-moderate atopic dermatitis with a topical non-steroidal agent. J Drugs Dermatol. 2009;8(6):537–9.
Mizushima H, Fukasawa J, Suzuki T. Phase behavior of artificial stratum corneum lipids containing a synthetic pseudo-ceramide: a study of the function of cholesterol. J Lipid Res. 1996;37:361–7. [PubMed: 9026533].
Park BD, Youm JK, Jeong SK, Choi EH, Ahn SH, Lee SH. The characterization of molecular organization of multilamellar emulsions containing pseudoceramide and type III synthetic ceramide. J Invest Dermatol. 2003;121:794–801. [PubMed: 14632198].
Noli C, Della Valle MF, Miolo A, Medori C, Schievano C. Efficacy of ultra-micronized palmitoylethanolamide in canine atopic dermatitis: an open-label multi-centre study. Skinalia Clinical Research Group. Vet Dermatol. 2015;26(6):432–40. e101.
Eberlein B, Eicke C, Reinhardt HW, Ring J. Adjuvant treatment of atopic eczema: assessment of an emollient containing N-palmitoylethanolamine (ATOPA study). J Eur Acad Dermatol Venereol. 2008;22(1):73–82.
Facci L, Toso RD, Romanello S, Buriani A, Skaper SD, Leon A. Mast cells express a peripheral cannabinoid receptor with differential sensitivity to anandamide andpalmitoylethanolamide. Proc Natl Acad Sci U S A. 1995;92:3376–80.
Ständer S, Schmelz M, Metze D, Luger T, Rukwied R. Distribution of cannabinoid receptor 1 (CB1) and 2 (CB2) on sensory nerve fibers and adnexal structures in human skin. J Dermatol Sci. 2005;38:177–88.
Nassiri-Asl M, Hosseinzadeh H. Review of the pharmacological effects of Vitis vinifera (Grape) and its bioactive compounds. Phytother Res. 2009;23(9):1197–204.
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Draelos, Z.D. (2019). Cosmeceuticals. In: Alam, M. (eds) Evidence-Based Procedural Dermatology. Springer, Cham. https://doi.org/10.1007/978-3-030-02023-1_30
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