Skip to main content
  • 1088 Accesses

Abstract

Nausea and vomiting are common symptoms that develop due to a variety of different etiologies. In this chapter, we will review the pathophysiology and epidemiology of nausea and vomiting, describe the broad differential of this common disorder, review the steps of a basic diagnostic evaluation, and discuss treatment options.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

eBook
USD 16.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Quigley EMM, Hasler WL, Parkman HP. AGA technical review on nausea and vomiting. Gastroenterology. 2001;120(1):263–86.

    Article  CAS  Google Scholar 

  2. Sharkey KA, Darmani NA, Parker LA. Regulation of nausea and vomiting by cannabinoids and the endocannabinoid system. Eur J Pharmacol. 2014;722:134–46.

    Article  CAS  Google Scholar 

  3. Camilleri M, Dubois D, Coulie B, Jones M, Kahrilas PJ, Rentz AM, et al. Prevalence and socioeconomic impact of upper gastrointestinal disorders in the United States: results of the US upper gastrointestinal study. Clin Gastroenterol Hepatol. 2005;3(6):543–52.

    Article  Google Scholar 

  4. Hornby PJ. Central neurocircuitry associated with emesis. Am J Med. 2001;111(Suppl 8A):112S.

    Google Scholar 

  5. Lang IM, Sarna SK, Dodds WJ. Pharyngeal, esophageal, and proximal gastric responses associated with vomiting. Am J Phys. 1993;265(5 Pt 1):963.

    Google Scholar 

  6. Gadsby R. Pregnancy sickness and symptoms: your questions answered. Prof Care Mother Child. 1994;4(1):16–7.

    CAS  PubMed  Google Scholar 

  7. Hasler WL, Chey WD. Nausea and vomiting. Gastroenterology. 2003;125(6):1860–7.

    Article  Google Scholar 

  8. Lacy BE, Parkman HP, Camilleri M. Chronic nausea and vomiting: evaluation and treatment. Am J Gastroenterol. 2018;113:647.

    Article  Google Scholar 

  9. Bharucha AE, Camilleri M, Forstrom LA, Zinsmeister AR. Relationship between clinical features and gastric emptying disturbances in diabetes mellitus. Clin Endocrinol. 2009;70(3):415–20.

    Article  Google Scholar 

  10. Hasler WL. Newest drugs for chronic unexplained nausea and vomiting. Curr Treat Options Gastroenterol. 2016;14(4):371–85.

    Article  Google Scholar 

  11. Camilleri M. Novel diet, drugs, and gastric interventions for gastroparesis. Clin Gastroenterol Hepatol. 2016;14(8):1072–80.

    Article  Google Scholar 

  12. Tack J, Carbone F. Functional dyspepsia and gastroparesis. Curr Opin Gastroenterol. 2017;33(6):446–54.

    Article  CAS  Google Scholar 

Essential Reading

  • Quigley EMM, Hasler WL, Parkman HP. AGA technical review on nausea and vomiting. Gastroenterology. 2001;120(1):263–86. This article provides an overview on nausea and vomiting and sets the framework for other papers

    Article  CAS  Google Scholar 

  • Lacy BE, Parkman HP, Camilleri M. Chronic nausea and vomiting: evaluation and treatment. Am J Gastroenterol. 2018. This article provides a recent update on nausea and vomiting with up-to-date diagnostic and treatment strategies.;113:647.

    Article  Google Scholar 

  • Hasler WL. Newest drugs for chronic unexplained nausea and vomiting. Curr Treat Options Gastroenterol. 2016;14(4):371–85. This article provides insight on the newer drugs for treatment of nausea and vomiting.

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Zubair Malik .

Editor information

Editors and Affiliations

Self-Test

Self-Test

  • Question 1. Where is the vomiting center located?

    1. A.

      Posterior lateral reticular formation of the medulla

    2. B.

      Dorsal lateral reticular formation of the medulla

    3. C.

      Posterior lateral reticular formation of the somatosensory cortex

    4. D.

      Doral lateral reticular formation of the somatosensory cortex

  • Question 2. All of the following are causes of nausea and vomiting except for:

    1. A.

      Cisplatinum

    2. B.

      Metoprolol

    3. C.

      Tetracycline

    4. D.

      Aprepitant

    5. E.

      Sulfasalazine

  • Question 3. In a patient with symptoms of nausea and vomiting, after ruling out a life threating illness, what is the next step in the approach?

    1. A.

      Remove offending agents

    2. B.

      Check blood work

    3. C.

      Check obstruction series

    4. D.

      Treat with antiemetics

Rights and permissions

Reprints and permissions

Copyright information

© 2019 Springer Nature Switzerland AG

About this chapter

Check for updates. Verify currency and authenticity via CrossMark

Cite this chapter

Malik, Z., Parkman, H.P. (2019). Approach to Nausea and Vomiting. In: Lacy, B., DiBaise, J., Pimentel, M., Ford, A. (eds) Essential Medical Disorders of the Stomach and Small Intestine. Springer, Cham. https://doi.org/10.1007/978-3-030-01117-8_1

Download citation

  • DOI: https://doi.org/10.1007/978-3-030-01117-8_1

  • Published:

  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-01116-1

  • Online ISBN: 978-3-030-01117-8

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics