Abstract
Puberty results from the complete maturation of the GnRH neuronal network. It marks the reactivation of this network after a long period of quiescence during childhood. This reactivation causes an increase of sexual hormones leading to the appearance of secondary sexual characteristic. Several neuropeptides have now been described. The age at puberty is a sensitive indicator of evolution.
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References
de Roux N, Genin E, Carel JC et al (2003) Hypogonadotropic hypogonadism due to loss of function of the KiSS1-derived peptide receptor GPR54. Proc Natl Acad Sci U S A 100:10972–10976
Seminara SB, Messager S, Chatzidaki EE et al (2003) The GPR54 gene as a regulator of puberty. N Engl J Med 349:1614–1627
Topaloglu AK, Reimann F, Guclu M et al (2009) TAC3 and TACR3 mutations in familial hypogonadotropic hypogonadism reveal a key role for Neurokinin B in the central control of reproduction. Nat Genet 41:354–358
Topaloglu AK, Tello JA, Kotan LD et al (2012) Inactivating KISS1 mutation and hypogonadotropic hypogonadism. N Engl J Med 366:629–635
Pinilla L, Aguilar E, Dieguez C et al (2012) Kisspeptins and reproduction: physiological roles and regulatory mechanisms. Physiol Rev 92:1235–1316
Goodman RL, Lehman MN (2012) Kisspeptin neurons from mice to men: similarities and differences. Endocrinology 153:5105–5118
Ducret E, Anderson GM, Herbison AE (2009) RFamide-related peptide-3, a mammalian gonadotropin-inhibitory hormone ortholog, regulates gonadotropin-releasing hormone neuron firing in the mouse. Endocrinology 150:2799–2804
Ojeda SR, Urbanski H (2007) Puberty in the rat. In: Neill D, Knobil E (eds) The physiology of reproduction. Place Raven Press, New York, pp 363–410
Ojeda SR, Lomniczi A, Mastronardi C et al (2006) Minireview: the neuroendocrine regulation of puberty: is the time ripe for a systems biology approach? Endocrinology 147:1166–1174
Sharif A, Baroncini M, Prevot V (2013) Role of glia in the regulation of gonadotropin-releasing hormone neuronal activity and secretion. Neuroendocrinology 98:1–15
Prevot V (2002) Glial-neuronal-endothelial interactions are involved in the control of GnRH secretion. J Neuroendocrinol 14:247–255
Bellefontaine N, Hanchate NK, Parkash J et al (2011) Nitric oxide as key mediator of neuron-to-neuron and endothelia-to-glia communication involved in the neuroendocrine control of reproduction. Neuroendocrinology 93:74–89
Guimiot F, Chevrier L, Dreux S et al (2012) Negative fetal FSH/LH regulation in late pregnancy is associated with declined kisspeptin/KISS1R expression in the tuberal hypothalamus. J Clin Endocrinol Metab 97:E2221–E2229
Wu FC, Borrow SM, Nicol K et al (1989) Ontogeny of pulsatile gonadotrophin secretion and pituitary responsiveness in male puberty in man: a mixed longitudinal and cross-sectional study. J Endocrinol 123:347–359
Abreu AP, Dauber A, Macedo DB et al (2013) Central precocious puberty caused by mutations in the imprinted gene MKRN3. N Engl J Med 368:2467–2475
Elias CF (2012) Leptin action in pubertal development: recent advances and unanswered questions. Trends Endocrinol Metab 23:9–15
Strobel A, Issad T, Camoin L et al (1998) A leptin missense mutation associated with hypogonadism and morbid obesity. Nat Genet 18:213–215
Zeinoaldini S, Swarts JJ, Van de Heijning BJ (2006) Chronic leptin infusion advances, and immunoneutralization of leptin postpones puberty onset in normally fed and feed restricted female rats. Peptides 27:1652–1658
Louis GW, Greenwald-Yarnell M, Phillips R et al (2011) Molecular mapping of the neural pathways linking leptin to the neuroendocrine reproductive axis. Endocrinology 152:2302–2310
Sisk CL, Foster DL (2004) The neural basis of puberty and adolescence. Nat Neurosci 7:1040–1047
Gottsch ML, Navarro VM, Zhao Z et al (2009) Regulation of Kiss1 and dynorphin gene expression in the murine brain by classical and nonclassical estrogen receptor pathways. J Neurosci 29:9390–9395
Clarkson J, Boon WC, Simpson ER et al (2009) Postnatal development of an estradiol-kisspeptin positive feedback mechanism implicated in puberty onset. Endocrinology 150:3214–3220
Sulem P, Gudbjartsson DF, Rafnar T et al (2009) Genome-wide association study identifies sequence variants on 6q21 associated with age at menarche. Nat Genet 41:734–738
Ong KK, Elks CE, Li S et al (2009) Genetic variation in LIN28B is associated with the timing of puberty. Nat Genet 41:729–733
He C, Kraft P, Chen C et al (2009) Genome-wide association studies identify loci associated with age at menarche and age at natural menopause. Nat Genet 41:724–728
Perry JR, Stolk L, Franceschini N et al (2009) Meta-analysis of genome-wide association data identifies two loci influencing age at menarche. Nat Genet 41:648–650
Zhu H, Shah S, Shyh-Chang N et al (2010) Lin28a transgenic mice manifest size and puberty phenotypes identified in human genetic association studies. Nat Genet 42:626–630
Lehrbach NJ, Armisen J, Lightfoot HL et al (2009) LIN-28 and the poly(U) polymerase PUP-2 regulate let-7 microRNA processing in Caenorhabditis elegans. Nat Struct Mol Biol 16:1016–1020
Peng S, Chen LL, Lei XX et al (2011) Genome-wide studies reveal that Lin28 enhances the translation of genes important for growth and survival of human embryonic stem cells. Stem Cells 29:496–504
Hoffmann K, Heller R (2011) Uniparental disomies 7 and 14. Best Pract Res Clin Endocrinol Metab 25:77–100
Lomniczi A, Loche A, Castellano JM et al (2013) Epigenetic control of female puberty. Nat Neurosci 16:281–289
Hochberg Z, Belsky J (2013) Evo-devo of human adolescence: beyond disease models of early puberty. BMC Med 11:113
Mouritsen A, Frederiksen H, Sorensen K et al (2013) Urinary phthalates from 168 girls and boys measured twice a year during a 5 year period: associations with adrenal androgen levels and puberty. J Clin Endocrinol Metab 98(9):3755–3764
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Villanueva, C., de Roux, N. (2016). Neuroendocrine Control of Puberty. In: Bouvattier, C., Pienkowski, C. (eds) Early Puberty. Springer, Paris. https://doi.org/10.1007/978-2-8178-0543-6_3
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DOI: https://doi.org/10.1007/978-2-8178-0543-6_3
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