Abstract
Apelin signaling plays a role in various physiological functions, notably at the vascular level where apelin acts as an angiogenic peptide. This chapter is dedicated to the involvement of apelin signaling in the formation of retinal vessels. The spatiotemporal expression of the apelin receptor and its ligand during retinal angiogenesis reveals unique properties. First, expression of both the receptor and the ligand is upregulated during the angiogenic phase and downregulated in the maturation phase. Second, the apelin receptor gene is selectively expressed in the venous compartment. Third, the apelin gene is highly expressed in tip cells whereas receptor transcripts are essentially detected in stalk cells. As VEGF (vascular endothelial growth factor) upregulates apelin gene expression, we propose a model in which the VEGF chemotactic signal from astrocyte to tip cells would be converted into an apelin proliferative signal from tip cells to stalk cells. Finally, in a mouse model of retinopathy of prematurity, expression of both the receptor and the ligand is reactivated during the neoangiogenic phase. Consequently, apelin signaling represents a promising pharmacological target for treating neovascular eye diseases.
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Audigier, Y., van den Berghe, L., Masri, B. (2014). Apelin Signaling in Retinal Angiogenesis. In: Feige, JJ., Pagès, G., Soncin, F. (eds) Molecular Mechanisms of Angiogenesis. Springer, Paris. https://doi.org/10.1007/978-2-8178-0466-8_6
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