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Medical Imaging Modalities

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Medical Imaging in Clinical Trials

Abstract

Medical imaging is now utilized extensively in clinical trials for eligibility, efficacy, and safety evaluations. The uses of imaging span from a qualitative assessment of disease findings to quantitative assessments, each resting on diagnosis of the condition or change in the severity of the condition. This introductory chapter is designed for the novice with a limited or no background in radiological techniques and aims to briefly review the different imaging techniques, technology, terminology, and optimal imaging uses.

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References

  1. Brant WE, Helms CA. Fundamentals of diagnostic radiology. 3rd ed. Philadelphia: Lippincott, Williams & Wilkins; 2007. p. xix. 1559 p.

    Google Scholar 

  2. Novelline RA, Squire LF. Squire’s fundamentals of radiology. 5th ed. Cambridge: Harvard University Press; 1997. p. xiv. 621 p.

    Google Scholar 

  3. Mettler FA. Essentials of radiology. 2nd ed. Philadelphia: Elsevier/Saunders; 2005. p. xi. 416 p.

    Google Scholar 

  4. Pearson D, Miller CG. Clinical trials in osteoporosis. 2nd ed. Nottingham/Newton: Springer; 2007. p. xiii. 292 p.

    Book  Google Scholar 

  5. Erkonen WE, Smith WL. Radiology 101 : the basics and fundamentals of imaging. 3rd ed. Philadelphia: Wolters Kluwer/Lippincott Williams & Wilkins; 2010. p. vi. 376 p.

    Google Scholar 

  6. Haacke EM. Magnetic resonance imaging: physical principles and sequence design. New York: Wiley; 1999. p. xxvii. 914 p.

    Google Scholar 

  7. McRobbie DW. MRI from picture to proton. 2nd ed. Cambridge/New York: Cambridge University Press; 2007. p. xii. 394 p.

    Google Scholar 

  8. Wood ML, et al. Physical MR desktop data. J Magn Reson Imaging. 1993;3(Suppl):19–24.

    Article  PubMed  Google Scholar 

  9. Yu HJ. Imaging markers of cognitive deficits in RRMS using a multimodal MR approach. In: Biomedical engineering. Stonybrook: Stony Brook University; 2011.

    Google Scholar 

  10. Mohamed FB, et al. Brain mapping of deception and truth telling about an ecologically valid situation: functional MR imaging and polygraph investigation–initial experience. Radiology. 2006;238(2):679–88.

    Article  PubMed  Google Scholar 

  11. FDA. FDA approves imaging drug Amyvid April 10, 2012; Available from: http://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm299678.htm.

  12. Bushberg JT. The essential physics of medical imaging. 3rd ed. Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins; 2012. p. xii. 1030 p.

    Google Scholar 

  13. Langton CM, Palmer SB, Porter RW. The measurement of broadband ultrasonic attenuation in cancellous bone. Eng Med. 1984;13(2):89–91.

    Article  CAS  PubMed  Google Scholar 

  14. Porter RW, et al. Prediction of hip fracture in elderly women: a prospective study. BMJ. 1990;301(6753):638–41.

    Article  CAS  PubMed  Google Scholar 

  15. Hans D, et al. Ultrasonographic heel measurements to predict hip fracture in elderly women: the EPIDOS prospective study. Lancet. 1996;348(9026):511–4.

    Article  CAS  PubMed  Google Scholar 

  16. FDA. Guidance for industry standards for clinical trial imaging endpoints. 2011. Available from: http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm268555.pdf.

  17. Levine D, Akikusa J, Manson D, Silverman E, Schneider R. Chest CT findings in pediatric Wegener’s granulomatosis. Pediatr Radiol. 2006;37(1):57–62.

    Article  PubMed  Google Scholar 

  18. Gupta N, Moore JP, Shannon K. A novel approach to eliminate intraventricular lead placement in patients with congenital heart disease. J Interv Card Electrophysiol. 2012;35(1):115–8.

    Article  PubMed  Google Scholar 

  19. Aberle D, El-saden S, Abbona P, Gomez A, Motamedi K, Ragavendra N, Bassett L, Seeger L, Brown M, Brown K, Bui AAT, Kangarloo H. A primer on imaging anatomy and physiology. In: Bui AAT, Taira RK, editors. Medical imaging informatics. New York: Springer Science + Business Media; 2010.

    Google Scholar 

  20. Zhang J, Yang G, Lee Y, Chang S, Lu J, Zhu O. Multiplexing radiography for ultra-fast computed tomography. Lay-language papers. AAPM meeting. Minneapolis; 23 July 2007.

    Google Scholar 

  21. Semrud-Clikeman M, Fine JG, Bledsoe J. Neuroimaging in women. In: Fletcher-Jansen E, editor. The neuropsychology of women. New York: Springer Science + Business Media; 2009.

    Google Scholar 

  22. Saha GB. Physics and radiobiology of nuclear medicine. New York: Springer Science + Business Media; 2013.

    Book  Google Scholar 

  23. Ridgway JP. Cardiovascular magnetic resonance physics for clinicians: part I. J Cardiovasc Magn Reson. 2010;12(71):12–71. doi:10.1186/1532-429X-12-71#_blank.

    Google Scholar 

  24. Scheef L, Frank T. Theoretical background of MR imaging. In: Boecker H, Hillman CH, Scheef L, Strüder HK, editors. Functional neuroimaging in exercise and sport sciences. New York: Springer Science + Business Media; 2012.

    Google Scholar 

  25. Johnström P, Fryer TD, Bird JL, Richards HK, Davenport AP. Dynamic in vivo imaging of receptors in small animals using positron emission tomography. In: Davenport AP, editor. Receptor binding techniques. New York: Humana Press; 2012.

    Google Scholar 

  26. Townsend DW. Design and operation of combined PET-CT scanners. In: Shreve P, Townsend W, editors. Clinical PET-CT in radiology. New York: Springer Science + Business Media; 2011.

    Google Scholar 

  27. Braunwald E (Series Editor), Beller GA (Volume Editor). Atlas of heart diseases, vol. 5: Chronic ischemic heart disease. Philadelphia: Current Medicine; 1995.

    Google Scholar 

  28. Duncan CB, Riall TS. Evidence-based current surgical practice: calculous gallbladder disease. J Gastrointest Surg. 2012;16(11):2011–25.

    Article  PubMed Central  PubMed  Google Scholar 

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Correspondence to Harris A. Ahmad MD .

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© 2014 Springer-Verlag London

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Ahmad, H.A., Yu, H.J., Miller, C.G. (2014). Medical Imaging Modalities. In: Miller, C., Krasnow, J., Schwartz, L. (eds) Medical Imaging in Clinical Trials. Springer, London. https://doi.org/10.1007/978-1-84882-710-3_1

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  • DOI: https://doi.org/10.1007/978-1-84882-710-3_1

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  • Publisher Name: Springer, London

  • Print ISBN: 978-1-84882-709-7

  • Online ISBN: 978-1-84882-710-3

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