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Overview of Skeletal Development

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Skeletal Development and Repair

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1130))

Abstract

Development of cartilage and bone, the core components of the mouse skeletal system, depends on the well-coordinated proliferation and differentiation of skeletogenic cells, including chondrocytes and osteoblasts. These cells differentiate from common progenitor cells originating in the mesoderm and neural crest. Multiple signaling pathways and transcription factors tightly regulate differentiation and proliferation of skeletal cells. In this chapter, we overview the process of mouse skeletal development and discuss major regulators of skeletal cells at each developmental stage.

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Authors and Affiliations

  1. Massachusetts General Hospital, Harvard University, Boston, MA, USA

    Tatsuya Kobayashi & Henry M. Kronenberg

Authors
  1. Tatsuya Kobayashi
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  2. Henry M. Kronenberg
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Editors and Affiliations

  1. Department of Orthopedics and Rehabilita, University of Rochester Medical Center, Rochester, New York, USA

    Matthew J. Hilton

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Kobayashi, T., Kronenberg, H.M. (2014). Overview of Skeletal Development. In: Hilton, M. (eds) Skeletal Development and Repair. Methods in Molecular Biology, vol 1130. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-989-5_1

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  • DOI: https://doi.org/10.1007/978-1-62703-989-5_1

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-988-8

  • Online ISBN: 978-1-62703-989-5

  • eBook Packages: Springer Protocols

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