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Monogenic and Polygenic Contributions to Hypertension

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Pediatric Hypertension

Part of the book series: Clinical Hypertension and Vascular Diseases ((CHVD))

Abstract

This chapter provides an overview of the genetics of hypertension, reviewing what is known about rare Mendelian forms of hypertension, which can be explained by mutations in single genes, as well as the genetics of primary hypertension. Different approaches such as candidate gene approaches, linkage studies, and genome-wide association studies are discussed. It is hoped that this chapter will provide a concise primer for reading the literature in the area of genetics and hypertension.

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Authors and Affiliations

  1. Pediatric Nephrology Unit, MassGeneral Hospital for Children at MGH, Harvard Medical School, Fruit St. 55, Boston, MA, 02114, USA

    Julie R. Ingelfinger M.D.

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  1. Julie R. Ingelfinger M.D.
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Correspondence to Julie R. Ingelfinger M.D. .

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  1. University of Washington, Division of Pediatrics, Seattle Children's Hospital, Sand Point Way NE. 4800, Seattle, 98105, Washington, USA

    Joseph T. Flynn

  2. Harvard Medical School, Pediatric Nephrology Unit, MassGeneral Hospital for Children at MGH, Fruit St. 55, Boston, 02114, Massachusetts, USA

    Julie R. Ingelfinger

  3. Global Clinical Research, Bristol-Myers Squibb, Route 206 & Provinceline Road, Princeton, 08543, New Jersey, USA

    Ronald J. Portman

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Ingelfinger, J.R. (2013). Monogenic and Polygenic Contributions to Hypertension. In: Flynn, J., Ingelfinger, J., Portman, R. (eds) Pediatric Hypertension. Clinical Hypertension and Vascular Diseases. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-490-6_6

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