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Cognitive Decline in Menopause

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Nutrition and Diet in Menopause

Part of the book series: Nutrition and Health ((NH))

Key Points

  • Cognitive decline in menopause affects episodic memory and executive functions.

  • These domains are postulated to be vulnerable to and modulated by exposure to endogenous and exogenous estrogens.

  • The significant amount of research that studies the relationship between estrogens and the cognitive performance in menopausal women has not produced consistent results in the last two decades.

  • Further investigation taking into account different aspects as cultural items, type of menopause (natural or surgical), type of impairment in the cognitive functioning, etc. is needed to finally answer the questions regarding the role of estrogens and hormone replacement therapy on cognition.

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Abbreviations

THR:

Therapy of hormone replacement

HT:

Hormone therapy

RT:

Reaction time

ET:

Estrogen replacement

ETR:

Estrogen replacement therapy

WHS:

Women’s Health Study

MT:

Menopausal transition

References

  1. Master W, Johnson V, Kolodny RC. La sexualidad humana. Barcelona: Grijalbo; 1987.

    Google Scholar 

  2. Comisión Europea. Green paper “Confronting demographic change: a new solidarity between generations”. 2002. Disponible en http://europa.eu.int-lex/lex/LexUriServ/site/en/com/2005/com2005_0094en04.pdf

  3. Larroy C. Trastornos específicos de la mujer. Madrid: Síntesis; 2004.

    Google Scholar 

  4. Hurtado F, Donat F, Poveda C, Rubio C, Ull N. Mujer y climaterio: un estudio para la mejora de la calidad de vida. Cuad Med Psicosom Psiquiatr Enlace. 1999;51/52:49–68.

    Google Scholar 

  5. Stanton A, Lobel M, Sears S, Stein De Luca R. Psychosocial aspects of selected issues in women’s reproductive health: current status and future directions. J Consult Clin Psychol. 2002;70(3):751–70.

    Article  PubMed  Google Scholar 

  6. Gold EB, Sternfeld B, Kelsey JL, Brown C, Mouton C, Reame N, et al. Relation of demographic and lifestyle factors to symptoms in a multi-racial/ethnic population of women 40–55 years of age. Am J Epidemiol. 1999;152(5):463–73.

    Article  Google Scholar 

  7. Dillaway H, Byrnes M, Miller S, Rehan S. Talking “amon us”: how women from different racial-ethnic groups define and discuss menopause. Health Care Women Int. 2008;29:766–81.

    Article  PubMed  Google Scholar 

  8. Delgado A, Sánchez MC, Galindo I, Pérez C, Duque MJ. Actitudes de las mujeres ante la menopausia y variables predoctoras. Aten Primaria. 2001;27(1):27–41.

    Article  Google Scholar 

  9. Acosta JI. Etiology of menopause impacts cognition. DAI B Sci Eng. 2010;70(11-B):7258.

    Google Scholar 

  10. Henderson VW, Popat RA. Effects of endogenous and exogenous estrogen exposures in midlife and late-life women on episodic memory and executive functions. Neuroscience. 2011;191(12):129–38.

    Article  PubMed  CAS  Google Scholar 

  11. Boulware MI, Kent BA, Frick KM. The impact of age-related ovarian hormone loss on cognitive and neural function. Curr Top Behav Neurosci. 2012;10:165–84.

    Article  PubMed  Google Scholar 

  12. Romeu A, Juliá M. Fisiología de la Menopausia. In: Sánchez-Cánovas J, editor. Menopausia y Salud. Barcelona: Ariel; 1996.

    Google Scholar 

  13. Carnicer C, Castro OP, Paublete MC. Aspectos básicos de la fisiología del climaterio. Psiquiatria.com: Interpsiquis 2002.

    Google Scholar 

  14. Leal Cercós C, Crespo HM. Introducción. In: Cercós L, editor. Trastornos depresivos en la mujer. Barcelona: Masson; 1999.

    Google Scholar 

  15. Bochino S. Aspectos psiconeuroendócrinos de la perimenopausia, menopausia y climaterio. Revista Psiquiátrica Urug. 2005;70(1):66–79.

    Google Scholar 

  16. González CO. Aspectos psiconeuroendocrinos del climaterio. In: Jadresic A, Ojeda C, Pérez G, editors. Psiconeuroendocrinología. Santiago: Mediterráneo; 2000.

    Google Scholar 

  17. Halbreich U, Lumley LA, Palter S, Manning C, Gengo F, Joe SH. Possible acceleration of age effects on cognition following menopause. J Psychiatr Res. 1995;29(3):153–63.

    Article  PubMed  CAS  Google Scholar 

  18. Genazzani AR, Spinetti A, Gallo R, Bernardi F. Menopause and the central nervous system: intervention options. Maturitas. 1999;31(2):103–10.

    Article  PubMed  CAS  Google Scholar 

  19. Rocca WA, Grossardt BR, Shuster LT. Oophorectomy, menopause, estrogen treatment, and cognitive aging: clinical evidence for a window of opportunity. Brain Res. 2011;1379:188–98.

    Article  PubMed  CAS  Google Scholar 

  20. Daniel JM, Bohacek J. The critical period hypothesis of estrogen effects on cognition: insights from basic research. Biochim Byophys Acta. 2010;1800(10):1068–76.

    Article  CAS  Google Scholar 

  21. Sherwin BB, Henry JF. Brain aging modulates the neuroprotective effects of estrogen on selective aspects of cognition in women: a critical review. Front Neuroendocrinol. 2008;29(1):88–113.

    Article  PubMed  CAS  Google Scholar 

  22. Ryan J, Carriere I, Scali J, Dartigues JF, Tzourio C, Poncet M, et al. Characteristics of hormone therapy, cognitive function, and dementia: the prospective 3C Study. Neurology. 2009;73(21):1729–37.

    Article  PubMed  CAS  Google Scholar 

  23. Korol DL, Manning CA. Effects of estrogen on cognition: implications for menopause. In: Carroll ME, Overmier JB, editors. Animal research and human health: advancing human welfare through behavioural science. Washington, DC: American Psychological Association; 2001. p. 305–22.

    Chapter  Google Scholar 

  24. Fillit H. Future therapeutic developments of estrogen use. J Clin Pharmacol. 1995;35(9 Suppl):25S–8.

    Article  PubMed  CAS  Google Scholar 

  25. Frick JM, Fernández SM, Harburger LL. A new approach to understanding the molecular mechanisms through wich estrogens affect cognition. Biochim Byophys Acta. 2010;1800(10):1045–55.

    Article  CAS  Google Scholar 

  26. Dumas JA, Kutz AM, Naylor MR, Jonhson JV, Newhouse PA. Increased memory load-related frontal activation after estradiol treatment in postmenopausal women. Horm Behav. 2010;58(5):929–35.

    Article  PubMed  CAS  Google Scholar 

  27. Gibbs RB. Estrogen therapy and cognition: a review of the cholinergic hypothesis. Endocr Rev. 2010;31(2):224–53.

    Article  PubMed  CAS  Google Scholar 

  28. Rice K, Morse C. Measuring cognition in menopause research: a review of test use. Climacteric. 2003;6(1):2–22.

    PubMed  CAS  Google Scholar 

  29. Miles C, Green R, Sanders G, Hines M. Estrogen and memory in a transsexual population. Horm Behav. 1998;34:199–208.

    Article  PubMed  CAS  Google Scholar 

  30. Tinelli A, Menis T, Brotto F, Tinelli R, Tinelli FG. Depression, menopause and hormonal replacement therapy (HRT). Minerva Ginecol. 2003;55(3):221–31.

    PubMed  CAS  Google Scholar 

  31. Henderson VW. Action of estrogens in the aging brain: dementia and cognitive aging. Biochim Biophys Acta. 2009;18020(10):1077–83.

    Article  Google Scholar 

  32. Leblanc ES, Neiss MB, Carello PE, Samuels MH, Janowsky JS. Hot Flashes and estrogen therapy do not influence cognition in early menopausal women. Menopause. 2007;14(2):191–202.

    Article  PubMed  Google Scholar 

  33. Hemerlink K, Henschel V, Untch M, Bauerfeind I, Lux MP, Munzel K. Short-term effects of treatment induced hormonal changes on cognitive function in breast cancer patients. Cancer. 2008;113(9):2431–9.

    Article  Google Scholar 

  34. Greendale GA, Huang MH, Wight RG, Lutters C, Avis N, Johnston J, et al. Effects of the menopause transition and hormone use on cognitive performance in midlife women. Neurology. 2009;72(21):1850–1857.

    Google Scholar 

  35. Mitchell ES, Woods NF. Cognitive symptoms during the menopausal transition and early postmenopause. Climacteric. 2011;14(2):252–61.

    Article  PubMed  CAS  Google Scholar 

  36. Morse CA, Rice K. Memory after menopause: preliminary considerations of hormone influence on cognitive functioning. Arch Womens Ment Health. 2005;8:155–62.

    Article  PubMed  CAS  Google Scholar 

  37. Picazo O, Espinosa-Raya J, Jimenez-Trejo F, Suarez J. Current Topics in Medicinal Chemistry Volume 11, 2011;13:1742–49(8).

    Article  PubMed  CAS  Google Scholar 

  38. Miles C, Green R, Hines M. Estrogen treatment effects on cognition, memory and mood in male-to-female transsexuals. Hormones and Behavior (2006) xxx–xxx. www.scienciedirect.com.

    Article  PubMed  CAS  Google Scholar 

  39. Talboom JS, Engler-Chiurazzi EB, Whiteaker P, Simard AR, Lukas R, Acosta JI, et al. A component of Premarin((R)) enhances multiple cognitive functions and influences nicotinic receptor expression. Horm Behav. 2010;58(5):917–28.

    Article  PubMed  CAS  Google Scholar 

  40. Hogervorst E, Bandelow S. Sex steroids to maintain cognitive function in women after the menopause: A meta-analyses of treatment trials. Maturitas. 2010;66(1):56–71.

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Cristina Larroy .

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Larroy, C., Vera, R. (2013). Cognitive Decline in Menopause. In: Hollins Martin, C., Watson, R., Preedy, V. (eds) Nutrition and Diet in Menopause. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-373-2_26

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  • DOI: https://doi.org/10.1007/978-1-62703-373-2_26

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-372-5

  • Online ISBN: 978-1-62703-373-2

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