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Diabetes and Exercise

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Endocrinology of Physical Activity and Sport

Part of the book series: Contemporary Endocrinology ((COE))

Abstract

Regular physical exercise should be recommended to type 1 diabetic persons similarly to nondiabetic subjects in order to maintain and improve health state. Almost all sport activities can be practiced by type 1 diabetic individuals if they are well trained to self-monitor their blood glucose and, consequently, to regulate carbohydrate intake and/or insulin dosage. In type 2 diabetes mellitus, regular physical exercise combined with appropriate lifestyle is an effective therapeutic tool for both diabetes care and diabetes prevention. Exercise exerts its positive effects mainly by increasing insulin sensitivity in skeletal muscle, the most important insulin-sensitive tissue. In muscle, exercise promotes insulin action, mitochondrial biogenesis and activity, lipid and glucose oxidation. The combination of aerobic and endurance training gives better results in ameliorating glucose control. Motivation of the great majority of subjects with type 2 diabetes to long-term practice of exercise is possible by means of validated strategies of counselling, integrated in structured multidisciplinary models of lifestyle intervention.

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References

  1. American Diabetes Association. Physical activity/exercise and diabetes. Diabetes Care. 2004;27:S58–62.

    Article  Google Scholar 

  2. Sigal RJ, Fisher SJ, Manzon A, Morais JA, et al. Glucoregulation during and after intense exercise: effects of α-adrenergic blockade. Metabolism. 2000;49:386–94.

    Article  PubMed  CAS  Google Scholar 

  3. Purdon C, Brousson M, Nyveen SL, et al. The roles of insulin and catecholamines in the glucoregulatory response during intense exercise and early recovery in insulin-dependent diabetic and control subjects. J Clin Endocrinol Metab. 1993;76:566–73.

    Article  PubMed  CAS  Google Scholar 

  4. Berger M, Berchtold P, Cüppers HJ, et al. Metabolic and hormonal effects of muscular exercise in juvenile type diabetics. Diabetologia. 1977;13:355–65.

    Article  PubMed  CAS  Google Scholar 

  5. Williams C. Physiological responses to exercise. In: Burr B, Nagi D, editors. Exercise and sport in diabetes. Chichester, England: Wiley; 1999. p. 1–24.

    Google Scholar 

  6. Santeusanio F, Di Loreto C, Lucidi P, et al. Diabetes and exercise. J Endocrinol Invest. 2003;26:937–40.

    PubMed  CAS  Google Scholar 

  7. De Feo P, Di Loreto C, Lucidi P, et al. Metabolic response to exercise. J Endocrinol Invest. 2003;26:851–4.

    PubMed  Google Scholar 

  8. Hossain P, Kawar B, El Nahas M. Obesity and diabetes in the developing world—a growing challenge. N Engl J Med. 2007;356:213–5.

    Article  PubMed  CAS  Google Scholar 

  9. WHO physical activity. Available from: http://www.who.int/moveforhealth/en/index.html (2011). Accessed 28 Oct 2011.

  10. Preventing Noncommunicable Diseases in the Workplace through Diet and Physical Activity.WH/World Economic Forum Report of a Joint Event. Available from: http://www.weforum.org/pdf/Wellness/WHO-WEF-NCDprevention.pdf (2011). Accessed 28 Oct 2011.

  11. Tuomiletho J, Lindstrom J, Eriksson JG, et al. Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med. 2001;344:1343–50.

    Article  Google Scholar 

  12. The Diabetes Prevention Programme Research Group. Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 2002;346:393–403.

    Article  Google Scholar 

  13. Paulweber B, Valensi P, Lindström J, et al. A European evidence-based guideline for the prevention of type 2 diabetes. Horm Metab Res. 2010;42 Suppl 1:S3–36.

    Article  PubMed  CAS  Google Scholar 

  14. Hood DA, Salem A. Exercise-induced mitochondrial biogenesis in skeletal muscle. Nutr Metab Cardiovasc Dis. 2007;17:332–7.

    Article  PubMed  CAS  Google Scholar 

  15. Baron AD, Brechtel G, Wallace P, et al. Rates and tissue sites on non-insulin- and insulin-mediated glucose uptake in humans. Am J Physiol. 1988;255:E769–74.

    PubMed  CAS  Google Scholar 

  16. Laaksonen DE, Lakka HM, Salonen JT, et al. Low levels of leisure-time physical activity and cardiorespiratory fitness predict development of the metabolic syndrome. Diabetes Care. 2002;25:1612–8.

    Article  PubMed  Google Scholar 

  17. Brage S, Wedderkopp N, Ekelund U, et al. European Youth Heart Study (EYHS). Features of the metabolic syndrome are associated with objectively measured physical activity and fitness in Danish children: the European Youth Heart Study (EYHS). Diabetes Care. 2004;27:2141–8.

    Article  PubMed  Google Scholar 

  18. Wisloff U, Najjar SM, Ellingsen O, et al. Cardiovascular risk factors emerge after artificial selection for low aerobic capacity. Science. 2005;307:418–20.

    Article  PubMed  CAS  Google Scholar 

  19. Kelley DE, He J, Menshikova EV, et al. Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes. Diabetes. 2002;51:2944–50.

    Article  PubMed  CAS  Google Scholar 

  20. De Feo P, Stocchi V. Physical activity for the treatment and prevention of metabolic syndrome. Nutr Metab Cardiovasc Dis. 2007;17:327–31.

    Article  Google Scholar 

  21. Guescini M, Fatone C, Stocchi L, et al. Fine needle aspiration coupled with real-time PCR: a painless methodology to study adaptive functional changes in skeletal muscle. Nutr Metab Cardiovasc Dis. 2007;17:383–93.

    Article  PubMed  CAS  Google Scholar 

  22. Di Loreto C, Fanelli C, Lucidi P, et al. Make your diabetic patients walk: long-term impact of different amounts of physical activity on type 2 diabetes. Diabetes Care. 2005;28:1295–302.

    Article  PubMed  Google Scholar 

  23. Bajpeyi S, Tanner CJ, Slentz CA, et al. Effect of exercise intensity and volume on the persistence of insulin sensitivity during training cessation. J Appl Physiol. 2009;106:1079–85.

    Article  PubMed  CAS  Google Scholar 

  24. Sigal RJ, Kenny GP, Wasserman DH, et al. Physical activity/exercise and type 2 diabetes: a consensus statement from the American Diabetes Association. Diabetes Care. 2006;29:1433–8.

    Article  PubMed  Google Scholar 

  25. Marwick TH, Hordern MD, Miller T, et al. Exercise training for type 2 diabetes mellitus: impact on cardiovascular risk: a scientific statement from the American Heart Association. Circulation. 2009;119:3244–62.

    Article  PubMed  Google Scholar 

  26. American College of Sports Medicine and the American Diabetes Association. Joint position statement: exercise and type 2 diabetes. Med Sci Sports Exerc. 2010;42:2282–303.

    Article  Google Scholar 

  27. Boulé NG, Haddad E, Kenny GP, et al. Effects of exercise on glycemic control and body mass in type 2 diabetes mellitus: a meta-analysis of controlled clinical trials. JAMA. 2001;286:1218–27.

    Article  PubMed  Google Scholar 

  28. Thomas DE, Elliott EJ, Naughton GA. Exercise for type 2 diabetes mellitus. Cochrane Database Syst Rev. 2006;3:CD002968.

    Google Scholar 

  29. Fatone C, Guescini M, Balducci S, et al. Two weekly sessions of combined aerobic and resistance exercise are sufficient to provide beneficial effects in subjects with Type 2 diabetes mellitus and metabolic syndrome. J Endocrinol Invest. 2010;33:489–95.

    PubMed  CAS  Google Scholar 

  30. Sigal RJ, Kenny GP, Boulé NG, et al. Effects of aerobic training, resistance training, or both on glycemic control in type 2 diabetes: a randomized trial. Ann Intern Med. 2007;147:357–69.

    PubMed  Google Scholar 

  31. Kirk A, De Feo P. Strategies to enhance compliance to physical activity for patients with insulin resistance. Appl Physiol Nutr Metab. 2007;32:549–56.

    Article  PubMed  Google Scholar 

  32. Di Loreto C, Fanelli C, Lucidi P, et al. Validation of a counseling strategy to promote the adoption and the maintenance of physical activity by type 2 diabetic subjects. Diabetes Care. 2003;26:404–8.

    Article  PubMed  Google Scholar 

  33. Kirk A, Mutrie N, MacIntyre P, Fisher M. Effects of a 12-month physical activity counselling intervention on glycaemic control and on the status of cardiovascular risk factors in people with type 2 diabetes. Diabetologia. 2004;47:821–32.

    Article  PubMed  CAS  Google Scholar 

  34. De Feo P, Fatone C, Burani P, Piana N, et al. An innovative model for changing the lifestyles of persons with obesity and/or type 2 diabetes mellitus. J Endocrinol Invest.2011;34:e349–e354.

    Google Scholar 

  35. De Feo P, Fatone C, Burani P, et al. A multidisciplinary approach for optimal use of exercise in diabetes care. International Diabetes Federation Congress, Dubai, 4–8 December 2011 (abstract 157, Open Forum Diabetes and Exercise).

    Google Scholar 

  36. Craig CL, Marshall AL, Sjöström M, et al. International physical activity questionnaire: 12-country reliability and validity. Med Sci Sports Exerc. 2003;35:1381–95.

    Article  PubMed  Google Scholar 

  37. Piana N, Battistini D, Urbani, L, Romani, G, Fatone C, Pazzagli C, Laghezza L, Mazzeschi C, De Feo P. Multidisciplinary lifestyle intervention in the obese: its impact on patients perception of the disease, food and physical exercise. Nutrition, Metabolism & Cardiovascular Diseases 2012 (in press); doi:10.1016/j.numecd.2011.12.008.

    Google Scholar 

  38. Mazzeschi C, Pazzagli C, Buratta L, Reboldi GP, Battistini D, Piana N, Pippi R, Fatone C, De Feo P. Mutual interactions between depression/quality of life and adherence to a multidisciplinary lifestyle intervention in obesity. J Clin Endocrinol Metab 2012;97: E2261–E2265.

    Google Scholar 

  39. Myers J, Prakash M, Froelicher V, et al. Exercise capacity and mortality among men referred for exercise testing. N Engl J Med. 2002;346:793–801.

    Article  PubMed  Google Scholar 

  40. Kokkinos P, Myers J, Nylen E, et al. Exercise capacity and all-cause mortality in African American and Caucasian men with type 2 diabetes. Diabetes Care. 2009;32:623–8.

    Article  PubMed  Google Scholar 

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Acknowledgements

The CURIAMO project is supported by a grant from the Department of Health of the Umbria Region (Italy). CURIAMO is referral institute of Italian Olympic Committee (CONI) for athletes with diabetes mellitus.

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Authors and Affiliations

  1. CURIAMO Healthy Lifestyle Institute, University of Perugia, Perugia, Italy

    Pierpaolo De Feo MD, Cristina Fatone MD & Dalila Battistini MD

  2. Dipartimento di Scienze Umane e della Formazione, University of Perugia, Perugia, Italy

    Claudia Mazzeschi PHD

Authors
  1. Pierpaolo De Feo MD
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  2. Cristina Fatone MD
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  3. Claudia Mazzeschi PHD
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  4. Dalila Battistini MD
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Corresponding author

Correspondence to Pierpaolo De Feo MD .

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Editors and Affiliations

  1. , Department of Orthopedic Surgery, Hadassah-Hebrew UMC, 4 Ha'razim St, Jerusalem, 91120, Jerusalem, Israel

    Naama Constantini

  2. , Applied Physiology Laboratory, UNC at Chapel Hill, 203 Fezter Hall, Chapel Hill, 27599, North Carolina, USA

    Anthony C. Hackney

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De Feo, P., Fatone, C., Mazzeschi, C., Battistini, D. (2013). Diabetes and Exercise. In: Constantini, N., Hackney, A. (eds) Endocrinology of Physical Activity and Sport. Contemporary Endocrinology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-314-5_25

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  • DOI: https://doi.org/10.1007/978-1-62703-314-5_25

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-313-8

  • Online ISBN: 978-1-62703-314-5

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