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Open Tubular Molecular Imprinted Phases in Chiral Capillary Electrochromatography

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Chiral Separations

Part of the book series: Methods in Molecular Biology ((MIMB,volume 970))

Abstract

A generalized preparation protocol for open tubular (OT) molecular imprinted polymer (MIP) silica capillary columns for chiral separations in capillary electrochromatography (CEC) is described. For ­different chiral molecules the same general composition of the MIP reaction mixture can be used except for the choice of the specific template. This protocol is valid for a variety of templates including acidic, basic, and neutral molecules, enabling formation of rugged and porous thin MIP layers on the inner surface of the capillary resulting in columns with high chiral separation efficiencies if the template has a good chiral recognition susceptibility.

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Acknowledgments

This work was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (2011–0003107).

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Authors and Affiliations

  1. Department of Chemistry, Inha University, Incheon, South Korea

    Won Jo Cheong & Song Hee Yang

Authors
  1. Won Jo Cheong
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  2. Song Hee Yang
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Corresponding author

Correspondence to Won Jo Cheong .

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Editors and Affiliations

  1. , Department of Pharmaceutical Chemistry, Friedrich-Schiller-University Jena, Philosophenweg 14, Jena, 07743, Germany

    Gerhard K. E. Scriba

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Cheong, W.J., Yang, S.H. (2013). Open Tubular Molecular Imprinted Phases in Chiral Capillary Electrochromatography. In: Scriba, G. (eds) Chiral Separations. Methods in Molecular Biology, vol 970. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-263-6_30

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  • DOI: https://doi.org/10.1007/978-1-62703-263-6_30

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-262-9

  • Online ISBN: 978-1-62703-263-6

  • eBook Packages: Springer Protocols

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