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Role of Gangliosides in Neurological Development and the Influence of Dietary Sources

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Nutrition in Infancy

Part of the book series: Nutrition and Health ((NH))

Abstract

Gangliosides are a wide family of glycosphingolipids that contain one or more sialic-acid residues. They were first extracted from brain “Ganglionzellen” (ganglions or neurons), hence the name, but occur in most animal tissues and fluids including blood, amniotic fluid and milk [1–3]. The profile and the concentration of gangliosides depend on the organ, sub-region of the organ, tissue or fluid as well as on the stage of cellular development and the age of the organism. Although gangliosides are present in all vertebrate cells, they are in unusually high concentration in the cells of the nervous system which, along with their spatial and temporal patterns of distribution, has led to the suggestion that they have a special role during neurological development.

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Authors and Affiliations

  1. Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil

    R. Mendez-Otero & P. M. Pimentel-Coelho

  2. Fonterra Research and Development Centre, Fonterra Co-operative Group Limited, Palmerston North, New Zealand

    S. Ukraintsev

  3. Department of Nutrition and Bioactives, Fonterra Research and Development Centre, Fonterra Co-operative Group, Dairy Farm Road, Palmerston North, New Zealand

    P. McJarrow Ph.D.

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  1. R. Mendez-Otero
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  1. Arizona Health Science Center, Mel and Enid Zuckerman, University of Arizona, 1295 N. Martin, Tucson, 85724-5155, Arizona, USA

    Ronald Ross Watson

  2. Centre for Gastroenterology, and Nutrition, University College London, Gower Street, London, WC1E 6BT, United Kingdom

    George Grimble

  3. School of Medicine, Diabetes & Nutritional, King's College London, 150 Stamford St., London, SE1 9NH, United Kingdom

    Victor R. Preedy

  4. Division of Health Promotion Sciences, Mel and Enid Zuckerman, University of Arizona, 1295 N. Martin Avenue, Tucson, 85724, Arizona, USA

    Sherma Zibadi

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Mendez-Otero, R., Pimentel-Coelho, P.M., Ukraintsev, S., McJarrow, P. (2013). Role of Gangliosides in Neurological Development and the Influence of Dietary Sources. In: Watson, R., Grimble, G., Preedy, V., Zibadi, S. (eds) Nutrition in Infancy. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-254-4_9

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