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Markers of Cellular Senescence

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Cell Senescence

Part of the book series: Methods in Molecular Biology ((MIMB,volume 965))

Abstract

Cellular senescence is a tumor suppression mechanism that evolved to limit duplication in somatic cells. Senescence is imposed by natural replicative boundaries or stress-induced signals, such as oncogenic transformation. Neoplastic cells can be forced to undergo senescence through genetic manipulations and epigenetic factors, including anticancer drugs, radiation, and differentiating agents. Senescent cells show distinct phenotypic and molecular characteristics, both in vitro or in vivo. These biomarkers might either cause or result from senescence induction, but could also be the byproducts of physiological changes in these non-replicating cells.

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Acknowledgments

This work was supported by grants from the Spanish Ministry of Science and Innovation and FEDER Funds (SAF2009-08605), Consejeria de Ciencia e Innovacion and Consejeria de Salud of the Junta de Andalucia (CTS-6844 and PI-0142). AC’s laboratory is also funded by a fellowship from Fundacion Oncologica FERO, supported by Fundació Josep Botet.

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  1. Instituto de Biomedicina, Hospital Universitario Virgen del Rocio, Sevilla, Spain

    Amancio Carnero

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  1. Amancio Carnero
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Correspondence to Amancio Carnero .

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Editors and Affiliations

  1. Institut Gustave Roussy, Pavillon de Recherche 1, INSERM U848, rue C. Desmoulins 39, Villejuif, 94085, France

    Lorenzo Galluzzi

  2. Institut Gustave Roussy, Pavillon de Recherche 1, INSERM U848, rue C. Desmoulins 39, Villejuif CEDEX, 94085, France

    Ilio Vitale

  3. Institut Gustave Roussy, Pavillon de Recherche 1, INSERM U848, rue C. Desmoulins 39, Villejuif CEDEX, 94085, France

    Oliver Kepp

  4. Institut Gustave Roussy (IGR), Pavillon de Recherche 1, INSERM, U848, rue Camille-Desmoulins 39, Villejuif, 94805, France

    Guido Kroemer

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Carnero, A. (2013). Markers of Cellular Senescence. In: Galluzzi, L., Vitale, I., Kepp, O., Kroemer, G. (eds) Cell Senescence. Methods in Molecular Biology, vol 965. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-239-1_4

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  • DOI: https://doi.org/10.1007/978-1-62703-239-1_4

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  • Publisher Name: Humana Press, Totowa, NJ

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