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Nesfatin-1: Its Role in the Diagnosis and Treatment of Obesity and Some Psychiatric Disorders

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Calcium-Binding Proteins and RAGE

Part of the book series: Methods in Molecular Biology ((MIMB,volume 963))

Abstract

We discovered a new anorexigenic protein, nesfatin/nucleobindin-2 (NUCB2), which includes an EF-hand, calcium-binding motif. Nesfatin/NUCB2 is converted to nesfatin-1, which may be a physiologically active form in the body. Centrally and systemically administered nesfatin-1 inhibits appetite and body weight gain in rodents. The mid-segment of nesfatin-1 appears to be important in the inhibition of food intake. Intranasal administration of the mid-segment inhibits appetite. Nesfatin-1 may also be involved in the regulation of gastrointestinal function and insulin secretion. We have summarized the recent progress in the research of nesfatin-1.

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Authors and Affiliations

  1. Department of Health and Nutrition, Faculty of Health and Welfare, Takasaki University of Health and Welfare, Takasaki, Gunma, Japan

    Hiroyuki Shimizu

  2. Department of Medicine and Molecular Science, Graduate School of Medicine, Gunma University, Maebashi, Gunma, Japan

    Masatomo Mori

Authors
  1. Hiroyuki Shimizu
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  2. Masatomo Mori
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Corresponding author

Correspondence to Hiroyuki Shimizu .

Editor information

Editors and Affiliations

  1. Div of Clinical Chem & Biochem, Department of Pediatrics, University of Zürich, Steinwiesstrasse 75, Zürich, 8032, Switzerland

    Claus W. Heizmann

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Shimizu, H., Mori, M. (2013). Nesfatin-1: Its Role in the Diagnosis and Treatment of Obesity and Some Psychiatric Disorders. In: Heizmann, C. (eds) Calcium-Binding Proteins and RAGE. Methods in Molecular Biology, vol 963. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-230-8_20

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  • DOI: https://doi.org/10.1007/978-1-62703-230-8_20

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-229-2

  • Online ISBN: 978-1-62703-230-8

  • eBook Packages: Springer Protocols

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