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Dorsal Root Injury for the Study of Spinal Cord Injury Repair

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Animal Models of Spinal Cord Repair

Part of the book series: Neuromethods ((NM,volume 76))

Abstract

Dorsal root injury provides opportunities for highly reproducible lesions and for detailed anatomical, physiological, and behavioral outcome assessment with high precision and validity. Dorsal root injury models are used to several aspects of relevance to spinal cord injury repair: (1) mechanisms of regeneration failure in the central nervous system and how to overcome it; (2) axon degeneration, as well as myelin degradation and elimination in the central nervous system—their roles and possible manipulations in spinal cord repair; (3) consequences in the spinal cord of mimicking human plexus injuries by dorsal root avulsion, including its effect on neuron survival, inflammatory processes, and vascular dysfunction; and (4) therapeutic strategies which may be translated to the treatment of clinical plexus avulsion injuries. This chapter describes various dorsal root injury models, their relationship to basic and translational aspects of spinal cord injury repair, as well as basic experimental procedures associated with these models in rat and mouse.

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Acknowledgments

The author’s cited work was supported by the Swedish Research Council, The Biomed II Program of the European Commission, Stiftelsen Olle Engkvist, and Sighnhild Engkvist’s Stiftelse.

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Authors and Affiliations

  1. Department of Neuroscience, Biomedical Center, Uppsala University, Uppsala, Sweden

    HÃ¥kan Aldskogius

  2. Department of Neuroscience, Uppsala University Biomedical Center, Uppsala, Sweden

    Elena N. Kozlova

Authors
  1. HÃ¥kan Aldskogius
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  2. Elena N. Kozlova
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Corresponding author

Correspondence to HÃ¥kan Aldskogius .

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Editors and Affiliations

  1. Biomedical Center, Department of Neuroscience, Uppsala University, Husargatan 3, Uppsala, 751 24, Sweden

    HÃ¥kan Aldskogius

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Aldskogius, H., Kozlova, E.N. (2013). Dorsal Root Injury for the Study of Spinal Cord Injury Repair. In: Aldskogius, H. (eds) Animal Models of Spinal Cord Repair. Neuromethods, vol 76. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-197-4_5

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  • DOI: https://doi.org/10.1007/978-1-62703-197-4_5

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  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-62703-196-7

  • Online ISBN: 978-1-62703-197-4

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