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Atypical Small Acinar Proliferation

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Prostate Cancer Diagnosis

Part of the book series: Current Clinical Urology ((CCU))

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Abstract

Atypical small-cell acinar proliferation (ASAP) has been reported in approximately 5–6 % of all of the prostate biopsies and is a clinically controversial diagnosis. Surveys have shown that many clinicians might not fully appreciate its definition finding it equivalent to high-grade prostatic intraepithelial neoplasia (HGPIN). The purpose of this chapter is to clarify the definition of ASAP, its histological findings, and clinical consequences. We propose a new follow-up approach following the diagnosis of ASAP, by increasing the number of repeat biopsies with consecutive negative results from two to three.

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Authors and Affiliations

  1. Department of Pathology and Genomic Medicine, The Methodist Hospital, 6565 Fannin St., Houston, TX, 77030, USA

    Adriana Olar M.D.

  2. Department of Pathology & Immunology, Baylor College of Medicine, BCM 315, One Baylor Plaza, Houston, TX, 77030, USA

    Thomas M. Wheeler M.D.

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  1. Adriana Olar M.D.
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Correspondence to Thomas M. Wheeler M.D. .

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Editors and Affiliations

  1. Cleveland Clinic, Cleveland Clinic Lerner College of Medic, Department of Regional Urology, at Case Western Reserve, Cleveland, 44195, Ohio, USA

    J. Stephen Jones

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Olar, A., Wheeler, T.M. (2013). Atypical Small Acinar Proliferation. In: Jones, J. (eds) Prostate Cancer Diagnosis. Current Clinical Urology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-188-2_19

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