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Alcohol in HIV and Possible Interactions with Antiretroviral Medications

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Alcohol, Nutrition, and Health Consequences

Part of the book series: Nutrition and Health ((NH))

Abstract

Chronic alcohol abuse is a contributing factor to HIV-1 transmission [1–3], disease progression [4, 5], and late presentation for diagnosis and early treatment [6]. The longitudinal effects of alcohol consumption in the context of antiretroviral therapy (ART), however, have not been sufficiently investigated beyond the well-documented behavioral consequences of alcoholism on ART adherence [7–9]. Nucleoside reverse transcriptase inhibitors (NRTI) have demonstrated their effectiveness as a family of antiretroviral drugs against HIV-1 for more than 15 years. NRTI in combination with non-NRTIs and protease inhibitors (PIs) are still the cornerstone of HIV treatment, despite their well-described side effects, including liver toxicity. Although the newest NRTIs are less liver-toxic with fewer side effects, the long-term multifactorial and synergistic interactions between alcohol consumption and HIV treatment have not been well documented [10, 11]. This chapter will explore the interaction between alcohol consumption and ART and the mechanistic roles of oxidative stress and mitochondrial DNA damage in explaining this interaction in people living with HIV.

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Authors and Affiliations

  1. College of Public Health and Social Work, Department of Dietetics and Nutrition, Florida International University, 1,200 SW 8th Street MM Campus, AHC-1-338, Miami, FL, 33199, USA

    Marianna K. Baum Ph.D.

  2. College of Public Health and Social Work, Department of Dietetics and Nutrition, Florida International University, 1,200 SW 8th Street MM Campus, AHC-1-340, Miami, FL, 33199, USA

    Sabrina Sales-Martinez M.S.

  3. College of Public Health and Social Work, Department of Dietetics and Nutrition, Florida International University, 1,200 SW 8th Street MM Campus, AHC-1-337, Miami, FL, 33199, USA

    Adriana Campa Ph.D.

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  1. Marianna K. Baum Ph.D.
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  2. Sabrina Sales-Martinez M.S.
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  3. Adriana Campa Ph.D.
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Correspondence to Marianna K. Baum Ph.D. .

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  1. Arizona Health Science Center, Mel and Enid Zuckerman College of Public, University of Arizona, 1501 N. Campbell Ave. ROOM 4335, TUCSON, 85724-5155, Arizona, USA

    Ronald Ross Watson

  2. Dept. Nutrition & Dietetics, King's College, Stamford St. 150, London, SE1 9NH, United Kingdom

    Victor R. Preedy

  3. Division of Health Promotion Sciences, Mel and Enid Zuckerman, University of Arizona, 1295 N. Martin Avenue, Tucson, 85724, Arizona, USA

    Sherma Zibadi

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Baum, M.K., Sales-Martinez, S., Campa, A. (2013). Alcohol in HIV and Possible Interactions with Antiretroviral Medications. In: Watson, R., Preedy, V., Zibadi, S. (eds) Alcohol, Nutrition, and Health Consequences. Nutrition and Health. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-047-2_18

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