Abstract
Premature rupture of membranes (PROM) is rupture of the chorioamniotic membranes before the onset of labor. The chorioamniotic sac requires a balance between collagen formation and enzymatic collagenolytic activity expressed in the fetal membrane. The amniotic membrane is a complex tissue in which collagen is fundamental for mechanical integrity and stress tolerance. Membrane rupture is associated with biochemical disturbances between collagen produced by fibroblasts and fetal membranes. An association exists between PROM and oxidative stress (OS) in pregnancy. Reactive oxygen species (ROS), which are unstable molecules produced in the body, may be the reason for the collagen damage. OS produced by augmented ROS production debilitates the collagen’s elasticity and strength, leading to PROM. Although antioxidants act as defense agents against oxidation, they have not been found to be protective against ROS and subsequent OS damage in PROM.
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References
Than NG, Romero R et al (2009) Mitochondrial manganese superoxide dismutase mRNA expression in human chorioamniotic membranes and its association with labor, inflammation, and infection. J Matern Fetal Neonatal Med 22(11):1000–1013
American College of Obstetricians and Gynecologists. (2007) Premature rupture of membranes. Obstet Gynecol 80:975–985
Lavery JP, Miller CE et al (1982) The effect of labor on the rheologic response of chorioamniotic membranes. Obstet Gynecol 60(1):87–92
McLaren J, Taylor DJ et al (1999) Increased incidence of apoptosis in non-labour-affected cytotrophoblast cells in term fetal membranes overlying the cervix. Hum Reprod 14(11):2895–2900
Mercer BM, Abdelrahim A et al (2010) The impact of vitamin C supplementation in pregnancy and in vitro upon fetal membrane strength and remodeling. Reprod Sci 17(7):685–695
Taylor J, Garite TJ (1984) Premature rupture of membranes before fetal viability. Obstet Gynecol 64(5):615–620
Naeye RL, Peters EC (1980) Causes and consequences of premature rupture of fetal membranes. Lancet 1(8161):192–194
Mathews F, Neil A (2005) Antioxidants and preterm prelabour rupture of the membranes. BJOG 112(5):588–594
Longini M, Perrone S et al (2007) Association between oxidative stress in pregnancy and preterm premature rupture of membranes. Clin Biochem 40(11):793–797
Woods JR, Jr (2001) Reactive oxygen species and preterm premature rupture of membranes-a review. Placenta 22 (Suppl A): S38–S44
Malak TM, Ockleford CD et al (1993) Confocal immunofluorescence localization of collagen types I, III, IV, V and VI and their ultrastructural organization in term human fetal membranes. Placenta 14(4):385–406
Fortunato SJ, Menon R et al (1999) Stromelysins in placental membranes and amniotic fluid with premature rupture of membranes. Obstet Gynecol 94(3):435–440
Buhimschi IA, Kramer WB et al (2000) Reduction-oxidation (redox) state regulation of matrix metalloproteinase activity in human fetal membranes. Am J Obstet Gynecol 182(2):458–464
Wall PD, Pressman EK et al (2002) Preterm premature rupture of the membranes and antioxidants: the free radical connection. J Perinat Med 30(6):447–457
Winterbourn CC, Chan T, Buss IH, Inder TE, Mogridge N, Darlow BA (2000) Protein carbonyls and lipid peroxidation products as oxidation markers in preterm infant plasma: associations with chronic lung disease and retinopathy and effects of selenium supplementation. Pediatr Res 48:84–90
Ogino M, Hiyamuta S et al (2005) Establishment of a prediction method for premature rupture of membranes in term pregnancy using active ceruloplasmin in cervicovaginal secretion as a clinical marker. J Obstet Gynaecol Res 5:1421–1426
Aplin JD, Campbell S et al (1986) Importance of vitamin C in maintenance of the normal amnion: an experimental study. Placenta 7(5):377–389
Casanueva E, Ripoll C et al (2005) Vitamin C supplementation to prevent premature rupture of the chorioamniotic membranes: a randomized trial. Am J Clin Nutr 81(4):859–863
Borna S, Borna H et al (2005) Vitamins C and E in the latency period in women with preterm premature rupture of membranes. Int J Gynaecol Obstet 90(1):16–20
Bolisetty S, Naidoo D et al (2002) Antenatal supplementation of antioxidant vitamins to reduce the oxidative stress at delivery–a pilot study. Early Hum Dev 67(1–2):47–53
Whittaker JW (2003) The irony of manganese superoxide dismutase. Biochem Soc Trans 31(Pt 6):1318–1321
Landis GN, Tower J (2005) Superoxide dismutase evolution and life span regulation. Mech Ageing Dev 126(3):365–379
Culotta VC, Yang M et al (2006) Activation of superoxide dismutases: putting the metal to the pedal. Biochim Biophys Acta 1763(7):747–758
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Aponte, A., Agarwal, A. (2013). Premature Rupture of Membranes and Oxidative Stress. In: Agarwal, A., Aziz, N., Rizk, B. (eds) Studies on Women's Health. Oxidative Stress in Applied Basic Research and Clinical Practice. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-62703-041-0_8
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DOI: https://doi.org/10.1007/978-1-62703-041-0_8
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