Abstract
The use of nanoparticulate systems for pulmonary drug delivery offers a number of advantages including the significantly improved delivery efficiency to the deep lung and the improved bioavailability. The traditional nanoparticle manufacturing process such as ball/jet milling may generate large aggregates, which could detrimentally inhibit the effective delivery of drug particles to the lower respiratory way. Here we report an alternative technique of spray-drying nanoemulsion to produce nanoparticles (<100 nm) that can be dispersed homogenously in the propellant to form an extremely stable pressurized metered dose inhaler formulation. Such nanoparticulate formulations dramatically improve the efficiency of drug delivery to the lungs, and therefore provide an ideal tool for pulmonary drug delivery.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Patton JS, Byron PR (2007) Inhaling medicines: delivering drugs to the body through the lungs. Nat Rev Drug Discov 6:67–74
Colthorpe P, Farr SJ, Taylor G, Smith IJ, Wyatt D (1992) The pharmacokinetics of pulmonary-delivered insulin: a comparison of intratracheal and aerosol administration to the rabbit. Pharm Res 9:764–768
Dolovich MA (2000) Influence of inspiratory flow rate, particle size, and airway caliber on aerosolized drug delivery to the lung. Respir Care 45:597–608
Mochalin VN, Sagar A, Gour S, Gogotsi Y (2009) Manufacturing nanosized fenofibrate by salt assisted milling. Pharm Res 26:1365–1370
Rasenack N, Müller BW (2002) Dissolution rate enhancement by in situ micronization of poorly water-soluble drugs. Pharm Res 19:1894–1900
Keck CM, Müller RH (2006) Drug nanocrystals of poorly soluble drugs produced by high pressure homogenisation. Eur J Pharm Biopharm 62:3–16
Chow AH, Tong HH, Chattopadhyay P, Shekunov BY (2007) Particle engineering for pulmonary drug delivery. Pharm Res 24:411–437
Thi THH, Danède F, Descamps M, Flament MP (2008) Comparison of physical and inhalation properties of spray-dried and micronized terbutaline sulphate. Eur J Pharm Biopharm 70:380–388
Jacobs C, Muller RH (2002) Production and characterization of a budesonide nanosuspension for pulmonary administration. Pharm Res 19:189–194
Rabinow BE (2004) Nanosuspensions in drug delivery. Nat Rev Drug Discov 3:785–796
Eastoe J, Hollamby MJ, Hudson L (2006) Recent advances in nanoparticle synthesis with reversed micelles. Adv Colloid Interface Sci 128–130:5–15
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer Science+Business Media, LLC
About this protocol
Cite this protocol
Li, HY., Zhang, F. (2012). Preparation of Nanoparticles by Spray-Drying and Their Use for Efficient Pulmonary Drug Delivery. In: Soloviev, M. (eds) Nanoparticles in Biology and Medicine. Methods in Molecular Biology, vol 906. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-953-2_23
Download citation
DOI: https://doi.org/10.1007/978-1-61779-953-2_23
Published:
Publisher Name: Humana Press, Totowa, NJ
Print ISBN: 978-1-61779-952-5
Online ISBN: 978-1-61779-953-2
eBook Packages: Springer Protocols