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Cutaneous Allergies

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Immunotoxicity, Immune Dysfunction, and Chronic Disease

Part of the book series: Molecular and Integrative Toxicology ((MOLECUL))

Abstract

Allergic contact dermatitis remains one of the most common occupational and environmental health issues. As with other forms of allergy the disease progresses in two stages: an initial “induction” phase during which sensitization is acquired, followed later (after subsequent exposure to the same chemical allergen) by “elicitation” of dermal inflammation. In recent years much has been learned about the characteristics of immune responses to skin sensitizing chemicals and the roles played by dendritic cells, cytokines and chemokines and real progress has been made. However, a current and significant challenge is how to replace in vivo methods with non-animal alternatives. This issue is given added significance via consideration of the clinical information, where the reality is that, despite useful toxicology methods, the burden of the disease remains substantial, with some contact allergies being at hyperendemic levels.

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Authors and Affiliations

  1. DABMEB Consultancy Ltd., 2 Normans Road, Sharnbrook, Bedford, MK44 1PR, UK

    David A. Basketter

  2. Cutaneous Allergy Unit, St. John’s Institute of Dermatology, St. Thomas’ Hospital, London, UK

    John P. McFadden

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  1. David A. Basketter
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Correspondence to David A. Basketter .

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Editors and Affiliations

  1. College of Veterinary Medicine, Dept. Microbiology & Immunology, Cornell University, Ithaca, 14853, New York, USA

    Rodney R. Dietert

  2. National Health and Environmental Effects, Research Laboratories, US Environmental Protection Agency, Research Triangle Park, 27711, USA

    Robert W. Luebke

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Basketter, D.A., McFadden, J.P. (2012). Cutaneous Allergies. In: Dietert, R., Luebke, R. (eds) Immunotoxicity, Immune Dysfunction, and Chronic Disease. Molecular and Integrative Toxicology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-61779-812-2_4

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