Skip to main content
SpringerLink
Log in

Epilepsy, Headache, and Sleep-Disordered Breathing

  • Chapter
  • First Online:
Sleep Disordered Breathing in Children

Part of the book series: Respiratory Medicine ((RM))

  • 1755 Accesses

Abstract

This chapter will discuss the connections between headaches and ­epilepsy in sleep-disordered breathing. In both adults and in children suffering from sleep-disordered breathing (SDB), headaches are a common complaint, and headache itself may be the presenting feature of obstructing sleep apnea (OSA). OSA has been found in children complaining of early morning headaches and as well as in specific headache syndromes, including migraine and tension-type headaches. Overall, the prevalence of OSA in patients with headache has been reported between 54% and 89%. In general, the most common complaints among the pediatric population with epilepsy have been related to poor quality sleep and anxieties about sleep resulting in excessive daytime sleepiness. Different aspects of epilepsy, such as use of antiepileptic drugs (AEDs), seizure frequency, and sleep-related seizures, may be possible contributing factors to sleep disturbances; however, some studies have found that OSA per se can be the sole predictor for daytime sleepiness in patients with epilepsy. Retrospective and prospective studies in children and adults have shown that up to 63% of patients with epilepsy are affected by SDB.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 139.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 179.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  1. Goder R, et al. Morning headaches in patients with sleep disorders: a systematic polysomnographic study. Sleep Med. 2003;4(5):385–91.

    Article  PubMed  Google Scholar 

  2. Paiva T, et al. The relationship between headaches and sleep disturbances. Headache. 1995;35(10):590–6.

    Article  PubMed  CAS  Google Scholar 

  3. Paiva T, et al. Chronic headaches and sleep disorders. Arch Intern Med. 1997;157(15):1701–5.

    Article  PubMed  CAS  Google Scholar 

  4. Poceta JS, Dalessio DJ. Identification and treatment of sleep apnea in patients with chronic headache. Headache. 1995;35(10):586–9.

    Article  PubMed  CAS  Google Scholar 

  5. Goder R, et al. Polysomnographic findings in nights preceding a migraine attack. Cephalalgia. 2001;21(1):31–7.

    Article  PubMed  CAS  Google Scholar 

  6. Loh NK, et al. Do patients with obstructive sleep apnea wake up with headaches? Arch Intern Med. 1999;159(15):1765–8.

    Article  PubMed  CAS  Google Scholar 

  7. Vendrame M, et al. Polysomnographic findings in children with headaches. Pediatr Neurol. 2008;39(1):6–11.

    Article  PubMed  Google Scholar 

  8. Rains J, Penzien D, Mohammed Y. Sleep and headache: morning headache associated with sleep disordered breathing (abstract). Cephalalgia. 2001;21:520.

    Article  Google Scholar 

  9. Rains JC, Poceta JS. Headache and sleep disorders: review and clinical implications for headache management. Headache. 2006;46(9):1344–63.

    Article  PubMed  Google Scholar 

  10. Arens R, Muzumdar H, Childhood obesity and obstructive sleep apnea syndrome. J Appl Physiol. 2010;108:436–44.

    Google Scholar 

  11. Kheirandish-Gozal L, Gozal D. The multiple challenges of obstructive sleep apnea in children: diagnosis. Curr Opin Pediatr. 2008;20(6):650–3.

    Article  PubMed  Google Scholar 

  12. Bruni O, et al. Prevalence of sleep disorders in childhood and adolescence with headache: a case–control study. Cephalalgia. 1997;17(4):492–8.

    Article  PubMed  CAS  Google Scholar 

  13. Chervin RD, et al. Timing patterns of cluster headaches and association with symptoms of obstructive sleep apnea. Sleep Res Online. 2000;3(3):107–12.

    PubMed  CAS  Google Scholar 

  14. Buckle P, Kerr P, Kryger M. Nocturnal cluster headache associated with sleep apnea. A case report. Sleep. 1993;16(5):487–9.

    PubMed  CAS  Google Scholar 

  15. Kudrow L, et al. Sleep apnea in cluster headache. Cephalalgia. 1984;4(1):33–8.

    Article  PubMed  CAS  Google Scholar 

  16. Nobre ME, Filho PF, Dominici M. Cluster headache associated with sleep apnoea. Cephalalgia. 2003;23(4):276–9.

    Article  PubMed  CAS  Google Scholar 

  17. Nath Zallek S, Chervin RD. Improvement in cluster headache after treatment for obstructive sleep apnea. Sleep Med. 2000;1(2):135–8.

    Article  PubMed  Google Scholar 

  18. Graff-Radford SB, Teruel A. Cluster headache and obstructive sleep apnea: are they related disorders? Curr Pain Headache Rep. 2009;13(2):160–3.

    Article  PubMed  Google Scholar 

  19. Kudrow L. Cluster headache: diagnosis and management. Headache. 1979;19(3):142–50.

    Article  PubMed  CAS  Google Scholar 

  20. Dodick DW, et al. Clinical, anatomical, and physiologic relationship between sleep and headache. Headache. 2003;43(3):282–92.

    Article  PubMed  Google Scholar 

  21. Goadsby PJ. Pathophysiology of cluster headache: a trigeminal autonomic cephalgia. Lancet Neurol. 2002;1(4):251–7.

    Article  PubMed  Google Scholar 

  22. Kunkle EC, Wolff HG. Headache; an outline for diagnosis and treatment. Med Clin North Am. 1948;32:557–69.

    PubMed  CAS  Google Scholar 

  23. Dexter JD, Weitzman ED. The relationship of nocturnal headaches to sleep stage patterns. Neurology. 1970;20(5):513–8.

    Article  PubMed  CAS  Google Scholar 

  24. Graff-Radford SB, Newman A. Obstructive sleep apnea and cluster headache. Headache. 2004;44(6):607–10.

    Article  PubMed  Google Scholar 

  25. Nobre ME, Leal AJ, Filho PM. Investigation into sleep disturbance of patients suffering from cluster headache. Cephalalgia. 2005;25(7):488–92.

    Article  PubMed  CAS  Google Scholar 

  26. Kothare SV, Kaleyias J. The clinical and laboratory assessment of the sleepy child. Semin Pediatr Neurol. 2008;15(2):61–9.

    Article  PubMed  Google Scholar 

  27. Holley S, Hill CM, Stevenson J. A comparison of actigraphy and parental report of sleep habits in typically developing children aged 6 to 11 years. Behav Sleep Med. 2010;8(1):16–27.

    Article  PubMed  Google Scholar 

  28. Goodlin-Jones BL, et al. The Children’s Sleep Habits Questionnaire in toddlers and preschool children. J Dev Behav Pediatr. 2008;29(2):82–8.

    Article  PubMed  Google Scholar 

  29. Heng K, Wirrell E. Sleep disturbance in children with migraine. J Child Neurol. 2006;21(9):761–6.

    Article  PubMed  Google Scholar 

  30. Spierings EL, Ranke AH, Honkoop PC. Precipitating and aggravating factors of migraine versus tension-type headache. Headache. 2001;41(6):554–8.

    Article  PubMed  CAS  Google Scholar 

  31. Spierings EL, van Hoof MJ. Fatigue and sleep in chronic headache sufferers: an age- and sex-controlled questionnaire study. Headache. 1997;37(9):549–52.

    Article  PubMed  CAS  Google Scholar 

  32. Miller VA, et al. Migraine headaches and sleep disturbances in children. Headache. 2003;43(4):362–8.

    Article  PubMed  CAS  Google Scholar 

  33. Sadeh A, Acebo C. The role of actigraphy in sleep medicine. Sleep Med Rev. 2002;6(2):113–24.

    Article  PubMed  Google Scholar 

  34. Bruni O, et al. Sleep and migraine: an actigraphic study. Cephalalgia. 2004;24(2):134–9.

    Article  PubMed  CAS  Google Scholar 

  35. Bursztein C, Steinberg T, Sadeh A. Sleep, sleepiness, and behavior problems in children with headache. J Child Neurol. 2006;21(12):1012–9.

    Article  PubMed  Google Scholar 

  36. Dexter JD. Headache and sleep. Headache. 1988;28(10):671–2.

    Article  PubMed  CAS  Google Scholar 

  37. Lewis D, et al. Practice parameter: pharmacological treatment of migraine headache in children and adolescents: report of the American Academy of Neurology Quality Standards Subcommittee and the Practice Committee of the Child Neurology Society. Neurology. 2004;63(12):2215–24.

    Article  PubMed  CAS  Google Scholar 

  38. Bruni O, Galli F, Guidetti V. Sleep hygiene and migraine in children and adolescents. Cephalalgia. 1999;19 Suppl 25:57–9.

    PubMed  Google Scholar 

  39. Biondi DM. Headaches and their relationship to sleep. Dent Clin North Am. 2001;45(4):685–700.

    PubMed  CAS  Google Scholar 

  40. Johal A, et al. The effect of a mandibular advancement splint in subjects with sleep-related breathing disorders. Br Dent J. 2005;199(9):591–6. discussion 581; quiz 608.

    Article  PubMed  CAS  Google Scholar 

  41. Gauthier L, et al. Efficacy of two mandibular advancement appliances in the management of snoring and mild-moderate sleep apnea: a cross-over randomized study. Sleep Med. 2009;10(3):329–36.

    Article  PubMed  Google Scholar 

  42. Kerby GR, Mayer LS, Pingleton SK. Nocturnal positive pressure ventilation via nasal mask. Am Rev Respir Dis. 1987;135(3):738–40.

    PubMed  CAS  Google Scholar 

  43. Kiely JL, Murphy M, McNicholas WT. Subjective efficacy of nasal CPAP therapy in obstructive sleep apnoea syndrome: a prospective controlled study. Eur Respir J. 1999;13(5):1086–90.

    Article  PubMed  CAS  Google Scholar 

  44. Baltzan MA, et al. Prevalence of persistent sleep apnea in patients treated with continuous positive airway pressure. Sleep. 2006;29(4):557–63.

    PubMed  Google Scholar 

  45. Ranieri AL, et al. Treatment of obstructive sleep apnea syndrome in patients from a teaching hospital in Brazil: is it possible? Sleep Breath. 2009;13(2):121–5.

    Article  PubMed  Google Scholar 

  46. Ranieri AL, Tufik S, de Siqueira JT. Refractory cluster headache in a patient with bruxism and obstructive sleep apnea: a case report. Sleep Breath. 2009;13(4):429–33.

    Article  PubMed  Google Scholar 

  47. Cruz MJ, et al. Efficacy and tolerability of topiramate in pediatric migraine. Pediatr Neurol. 2009;41(3):167–70.

    Article  PubMed  Google Scholar 

  48. Huang J, et al. Chronic intermittent hypoxia modulates nNOS mRNA and protein expression in the rat hypothalamus. Respir Physiol Neurobiol. 2007;158(1):30–8.

    Article  PubMed  CAS  Google Scholar 

  49. Ma S, et al. Chronic intermittent hypoxia sensitizes acute hypothalamic-pituitary-adrenal stress reactivity and Fos induction in the rat locus coeruleus in response to subsequent immobilization stress. Neuroscience. 2008;154(4):1639–47.

    Article  PubMed  CAS  Google Scholar 

  50. Leone M, Bussone G. A review of hormonal findings in cluster headache. Evidence for hypothalamic involvement. Cephalalgia. 1993;13(5):309–17.

    Article  PubMed  CAS  Google Scholar 

  51. Leone M, et al. Twenty-four-hour melatonin and cortisol plasma levels in relation to timing of cluster headache. Cephalalgia. 1995;15(3):224–9.

    Article  PubMed  CAS  Google Scholar 

  52. Treiser SL, et al. Lithium increases serotonin release and decreases serotonin receptors in the hippocampus. Science. 1981;213(4515):1529–31.

    Article  PubMed  CAS  Google Scholar 

  53. May A, et al. Hypothalamic activation in cluster headache attacks. Lancet. 1998;352(9124):275–8.

    Article  PubMed  CAS  Google Scholar 

  54. May A, et al. Correlation between structural and functional changes in brain in an idiopathic headache syndrome. Nat Med. 1999;5(7):836–8.

    Article  PubMed  CAS  Google Scholar 

  55. Stores G, Wiggs L, Campling G. Sleep disorders and their relationship to psychological disturbance in children with epilepsy. Child Care Health Dev. 1998;24(1):5–19.

    Article  PubMed  CAS  Google Scholar 

  56. Cortesi F, Giannotti F, Ottaviano S. Sleep problems and daytime behavior in childhood idiopathic epilepsy. Epilepsia. 1999;40(11):1557–65.

    Article  PubMed  CAS  Google Scholar 

  57. Malow BA, Bowes RJ, Lin X. Predictors of sleepiness in epilepsy patients. Sleep. 1997;20(12):1105–10.

    PubMed  CAS  Google Scholar 

  58. Malow BA, et al. Obstructive sleep apnea is common in medically refractory epilepsy patients. Neurology. 2000;55(7):1002–7.

    Article  PubMed  CAS  Google Scholar 

  59. Malow BA, Fromes GA, Aldrich MS. Usefulness of polysomnography in epilepsy patients. Neurology. 1997;48(5):1389–94.

    Article  PubMed  CAS  Google Scholar 

  60. Beran RG, Plunkett MJ, Holland GJ. Interface of epilepsy and sleep disorders. Seizure. 1999;8(2):97–102.

    Article  PubMed  CAS  Google Scholar 

  61. Weatherwax KJ, et al. Obstructive sleep apnea in epilepsy patients: the Sleep Apnea scale of the Sleep Disorders Questionnaire (SA-SDQ) is a useful screening instrument for obstructive sleep apnea in a disease-specific population. Sleep Med. 2003;4(6):517–21.

    Article  PubMed  Google Scholar 

  62. Malow BA, et al. Identification and treatment of obstructive sleep apnea in adults and children with epilepsy: a prospective pilot study. Sleep Med. 2003;4(6):509–15.

    Article  PubMed  Google Scholar 

  63. Manni R, et al. Obstructive sleep apnea in a clinical series of adult epilepsy patients: frequency and ­features of the comorbidity. Epilepsia. 2003;44(6):836–40.

    Article  PubMed  Google Scholar 

  64. Koh S, et al. Sleep apnea treatment improves seizure control in children with neurodevelopmental disorders. Pediatr Neurol. 2000;22(1):36–9.

    Article  PubMed  CAS  Google Scholar 

  65. Hollinger P, et al. Epilepsy and obstructive sleep apnea. Eur Neurol. 2006;55(2):74–9.

    Article  PubMed  Google Scholar 

  66. Kaleyias J, et al. Spectrum of polysomnographic abnormalities in children with epilepsy. Pediatr Neurol. 2008;39(3):170–6.

    Article  PubMed  Google Scholar 

  67. Piperidou C, et al. Association of demographic, clinical and treatment variables with quality of life of patients with epilepsy in Greece. Qual Life Res. 2008;17(7):987–96.

    Article  PubMed  Google Scholar 

  68. Pelc K, et al. Epilepsy in Angelman syndrome. Seizure. 2008;17(3):211–7.

    Article  PubMed  Google Scholar 

  69. Miano S, et al. Sleep breathing and periodic leg movement pattern in Angelman Syndrome: a polysomnographic study. Clin Neurophysiol. 2005;116(11):2685–92.

    PubMed  Google Scholar 

  70. Percy AK. Rett syndrome. Current status and new vistas. Neurol Clin. 2002;20(4):1125–41.

    Article  PubMed  Google Scholar 

  71. Glaze DG, Schultz RJ, Frost JD. Rett syndrome: characterization of seizures versus non-seizures. Electroencephalogr Clin Neurophysiol. 1998;106(1):79–83.

    Article  PubMed  CAS  Google Scholar 

  72. Cirignotta F, Lugaresi E, Montagna P. Breathing impairment in Rett syndrome. Am J Med Genet Suppl. 1986;1:167–73.

    Article  PubMed  CAS  Google Scholar 

  73. Schluter B, et al. Polysomnographic recordings of respiratory disturbances in Rett syndrome. J Sleep Res. 1995;4(S1):203–7.

    Article  PubMed  Google Scholar 

  74. Kerr AM. A review of the respiratory disorder in the Rett syndrome. Brain Dev. 1992;14(Suppl):S43–5.

    PubMed  Google Scholar 

  75. Marcus CL, et al. Polysomnographic characteristics of patients with Rett syndrome. J Pediatr. 1994;125(2):218–24.

    Article  PubMed  CAS  Google Scholar 

  76. Julu PO, et al. Functional evidence of brain stem immaturity in Rett syndrome. Eur Child Adolesc Psychiatry. 1997;6 Suppl 1:47–54.

    PubMed  Google Scholar 

  77. Katz DM, et al. Breathing disorders in Rett syndrome: progressive neurochemical dysfunction in the respiratory network after birth. Respir Physiol Neurobiol. 2009;168(1–2):101–8.

    Article  PubMed  CAS  Google Scholar 

  78. Nunes ML, et al. Sleep organization in children with partial refractory epilepsy. J Child Neurol. 2003;18(11):763–6.

    Article  PubMed  Google Scholar 

  79. Maganti R, et al. Sleep architecture in children with idiopathic generalized epilepsy. Epilepsia. 2005;46(1):104–9.

    Article  PubMed  Google Scholar 

  80. Nagarajan L, et al. Respiratory pattern changes in sleep in children on vagal nerve stimulation for refractory epilepsy. Can J Neurol Sci. 2003;30(3):224–7.

    PubMed  Google Scholar 

  81. Kotagal S, Gibbons VP, Stith JA. Sleep abnormalities in patients with severe cerebral palsy. Dev Med Child Neurol. 1994;36(4):304–11.

    Article  PubMed  CAS  Google Scholar 

  82. Becker DA, Fennell EB, Carney PR. Sleep disturbance in children with epilepsy. Epilepsy Behav. 2003;4(6):651–8.

    Article  PubMed  Google Scholar 

  83. Kothare SV, Pomeroy SL. Pediatric sleep medicine in 2008: state-of-the-art. Curr Opin Pediatr. 2008;20(6):639–40.

    Article  PubMed  Google Scholar 

  84. Devinsky O, et al. Epilepsy and sleep apnea syndrome. Neurology. 1994;44(11):2060–4.

    Article  PubMed  CAS  Google Scholar 

  85. Vaughn BV, et al. Improvement of epileptic seizure control with treatment of obstructive sleep apnoea. Seizure. 1996;5(1):73–8.

    Article  PubMed  CAS  Google Scholar 

  86. Sonka K, et al. Compliance in treatment of the sleep apnea syndrome using continuous positive pressure respiration. Cas Lek Cesk. 1997;136(11):348–51.

    PubMed  CAS  Google Scholar 

  87. Miano S, et al. Role of continuous positive airway pressure therapy on the pathogenesis of sleep-related frontal lobe epilepsy in a child with obstructive sleep apnea syndrome. J Child Neurol. 2008;23(1):124–8.

    Article  PubMed  Google Scholar 

  88. Minecan D, et al. Relationship of epileptic seizures to sleep stage and sleep depth. Sleep. 2002;25(8):899–904.

    PubMed  Google Scholar 

  89. Miano S, et al. Development of NREM sleep instability-continuity (cyclic alternating pattern) in healthy term infants aged 1 to 4 months. Sleep. 2009;32(1):83–90.

    PubMed  Google Scholar 

  90. Touchon J, et al. Sleep organization and epilepsy. Epilepsy Res Suppl. 1991;2:73–81.

    PubMed  CAS  Google Scholar 

  91. Jones BE. Glia, adenosine, and sleep. Neuron. 2009;61(2):156–7.

    Article  PubMed  CAS  Google Scholar 

  92. Landolt HP. Sleep homeostasis: a role for adenosine in humans? Biochem Pharmacol. 2008;75(11):2070–9.

    Article  PubMed  CAS  Google Scholar 

  93. Boison D, Stewart KA. Therapeutic epilepsy research: from pharmacological rationale to focal adenosine augmentation. Biochem Pharmacol. 2009;78(12):1428–37.

    Article  PubMed  CAS  Google Scholar 

  94. Saper CB. Staying awake for dinner: hypothalamic integration of sleep, feeding, and circadian rhythms. Prog Brain Res. 2006;153:243–52.

    Article  PubMed  CAS  Google Scholar 

  95. Benarroch EE. Suprachiasmatic nucleus and melatonin: reciprocal interactions and clinical correlations. Neurology. 2008;71(8):594–8.

    Article  PubMed  Google Scholar 

  96. Saper CB, Scammell TE, Lu J. Hypothalamic regulation of sleep and circadian rhythms. Nature. 2005;437(7063):1257–63.

    Article  PubMed  CAS  Google Scholar 

  97. Stewart LS, Leung LS. Hippocampal melatonin receptors modulate seizure threshold. Epilepsia. 2005;46(4):473–80.

    Article  PubMed  CAS  Google Scholar 

  98. Yildirim M, Marangoz C. Anticonvulsant effects of melatonin on penicillin-induced epileptiform activity in rats. Brain Res. 2006;1099(1):183–8.

    Article  PubMed  CAS  Google Scholar 

  99. Munoz-Hoyos A, et al. Melatonin’s role as an anticonvulsant and neuronal protector: experimental and clinical evidence. J Child Neurol. 1998;13(10):501–9.

    Article  PubMed  CAS  Google Scholar 

  100. Sheldon SH. Pro-convulsant effects of oral melatonin in neurologically disabled children. Lancet. 1998;351(9111):1254.

    Article  PubMed  CAS  Google Scholar 

  101. Peled N, et al. Melatonin effect on seizures in children with severe neurologic deficit disorders. Epilepsia. 2001;42(9):1208–10.

    Article  PubMed  CAS  Google Scholar 

  102. Bjorkman ST, et al. Seizures are associated with brain injury severity in a neonatal model of hypoxia-ischemia. Neuroscience. 2010;166(1):157–67.

    Article  PubMed  CAS  Google Scholar 

  103. Whelan J, et al. Sensitivity to seizure-like activity in Drosophila following acute hypoxia and hypercapnia. Brain Res. 2010;1316:120–8.

    Article  PubMed  CAS  Google Scholar 

  104. Rubaj A, Zgodzinski W, Sieklucka-Dziuba M. The epileptogenic effect of seizures induced by hypoxia: the role of NMDA and AMPA/KA antagonists. Pharmacol Biochem Behav. 2003;74(2):303–11.

    Article  PubMed  CAS  Google Scholar 

  105. Johnston MV. Excitotoxicity in neonatal hypoxia. Ment Retard Dev Disabil Res Rev. 2001;7(4):229–34.

    Article  PubMed  CAS  Google Scholar 

  106. Bazil CW. Nocturnal seizures and the effects of anticonvulsants on sleep. Curr Neurol Neurosci Rep. 2008;8(2):149–54.

    Article  PubMed  CAS  Google Scholar 

  107. Bazil CW. Nocturnal seizures. Semin Neurol. 2004;24(3):293–300.

    Article  PubMed  Google Scholar 

  108. Bazil CW, Castro LH, Walczak TS. Reduction of rapid eye movement sleep by diurnal and nocturnal seizures in temporal lobe epilepsy. Arch Neurol. 2000;57(3):363–8.

    Article  PubMed  CAS  Google Scholar 

  109. Foldvary-Schaefer N, Stephenson L, Bingaman W. Resolution of obstructive sleep apnea with epilepsy surgery? Expanding the relationship between sleep and epilepsy. Epilepsia. 2008;49(8):1457–9.

    Article  PubMed  Google Scholar 

  110. Blum AS, et al. Oxygen desaturations triggered by partial seizures: implications for cardiopulmonary instability in epilepsy. Epilepsia. 2000;41(5):536–41.

    Article  PubMed  CAS  Google Scholar 

  111. Tezer FI, Remi J, Noachtar S. Ictal apnea of epileptic origin. Neurology. 2009;72(9):855–7.

    Article  PubMed  Google Scholar 

  112. O’Regan ME, Brown JK. Abnormalities in cardiac and respiratory function observed during seizures in childhood. Dev Med Child Neurol. 2005;47(1):4–9.

    Article  PubMed  Google Scholar 

  113. Nashef L, et al. Apnoea and bradycardia during epileptic seizures: relation to sudden death in epilepsy. J Neurol Neurosurg Psychiatry. 1996;60(3):297–300.

    Article  PubMed  CAS  Google Scholar 

  114. Trotti LM, Bliwise DL. Sleep apnea as a transient, post-ictal event: report of a case. Epilepsy Res. 2009;85(2–3):325–8.

    Article  PubMed  Google Scholar 

  115. Moseley BD, et al. How common is ictal hypoxemia and bradycardia in children with partial complex and generalized convulsive seizures? Epilepsia. 2010;51(7):1219–24.

    Article  PubMed  Google Scholar 

  116. Lee HW, et al. Partial seizures manifesting as apnea only in an adult. Epilepsia. 1999;40(12):1828–31.

    Article  PubMed  CAS  Google Scholar 

  117. Seyal M, Bateman LM. Ictal apnea linked to contralateral spread of temporal lobe seizures: Intracranial EEG recordings in refractory temporal lobe epilepsy. Epilepsia. 2009;50(12):2557–62.

    Article  PubMed  Google Scholar 

  118. Abramo TJ, et al. Noninvasive capnometry ­monitoring for respiratory status during pediatric seizures. Crit Care Med. 1997;25(7):1242–6.

    Article  PubMed  CAS  Google Scholar 

  119. Nashef L, Ryvlin P. Sudden unexpected death in epilepsy (SUDEP): update and reflections. Neurol Clin. 2009;27(4):1063–74.

    Article  PubMed  Google Scholar 

  120. Asadi-Pooya AA, Sperling MR. Clinical Features of Sudden Unexpected Death in Epilepsy. J Clin Neurophysiol. 2009;15:330–2.

    Google Scholar 

  121. Terra VC, et al. Does sudden unexpected death in children with epilepsy occur more frequently in those with high seizure frequency? Arq Neuropsiquiatr. 2009;67(4):1001–2.

    Article  PubMed  Google Scholar 

  122. Tomson T, Nashef L, Ryvlin P. Sudden unexpected death in epilepsy: current knowledge and future directions. Lancet Neurol. 2008;7(11):1021–31.

    Article  PubMed  Google Scholar 

  123. Langan Y, Nashef L, Sander JW. Sudden unexpected death in epilepsy: a series of witnessed deaths. J Neurol Neurosurg Psychiatry. 2000;68(2):211–3.

    Article  PubMed  CAS  Google Scholar 

  124. So EL, Sam MC, Lagerlund TL. Postictal central apnea as a cause of SUDEP: evidence from near-SUDEP incident. Epilepsia. 2000;41(11):1494–7.

    Article  PubMed  CAS  Google Scholar 

  125. Vonck K, De Herdt V, Boon P. Vagal nerve stimulation–a 15-year survey of an established treatment modality in epilepsy surgery. Adv Tech Stand Neurosurg. 2009;34:111–46.

    Article  PubMed  CAS  Google Scholar 

  126. Ebben MR, et al. Vagus nerve stimulation, sleep apnea, and CPAP titration. J Clin Sleep Med. 2008;4(5):471–3.

    PubMed  Google Scholar 

  127. Malow BA, et al. Effects of vagus nerve stimulation on respiration during sleep: a pilot study. Neurology. 2000;55(10):1450–4.

    Article  PubMed  CAS  Google Scholar 

  128. Khurana DS, et al. Vagus nerve stimulation in children with refractory epilepsy: unusual complications and relationship to sleep-disordered breathing. Childs Nerv Syst. 2007;23(11):1309–12.

    Article  PubMed  Google Scholar 

  129. Chan J, Edman JC, Koltai PJ. Obstructive sleep apnea in children. Am Fam Physician. 2004;69(5):1147–54.

    PubMed  Google Scholar 

  130. Abaci A, et al. Metabolic alterations during valproic acid treatment: a prospective study. Pediatr Neurol. 2009;41(6):435–9.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurology, Boston University Medical Center, 72 East Concord Street, Neurology, C-3, Boston, MA, 02118, USA

    Martina Vendrame MD, PhD

  2. Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Children’s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Fegan 9, Boston, MA, 02115, USA

    Sanjeev V. Kothare MD

  3. Center for Pediatric Sleep Disorders, Department of Neurology, Children’s Hospital Boston, Harvard Medical School, 300 Longwood Avenue, Fegan 9, Boston, MA, 02115, USA

    Sanjeev V. Kothare MD

Authors
  1. Martina Vendrame MD, PhD
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Sanjeev V. Kothare MD
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Martina Vendrame MD, PhD .

Editor information

Editors and Affiliations

  1. Section of Sleep Medicine, Pritzker School of Medicine, Department of Pediatrics, S. Maryland Ave. 5721, Chicago, 60637, Illinois, USA

    Leila Kheirandish-Gozal

  2. Pritzker School of Medicine, Comer Children's Hospital, Department of Pediatrics, S. Maryland Ave. 5721, Chicago, 60637, Illinois, USA

    David Gozal

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer Science+Business Media New York

About this chapter

Cite this chapter

Vendrame, M., Kothare, S.V. (2012). Epilepsy, Headache, and Sleep-Disordered Breathing. In: Kheirandish-Gozal, L., Gozal, D. (eds) Sleep Disordered Breathing in Children. Respiratory Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-725-9_26

Download citation

  • DOI: https://doi.org/10.1007/978-1-60761-725-9_26

  • Published:

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-60761-724-2

  • Online ISBN: 978-1-60761-725-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation