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Chemoreceptors, Breathing, and Sleep

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Sleep Disordered Breathing in Children

Part of the book series: Respiratory Medicine ((RM))

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Abstract

Oxygen (O2) and carbon dioxide (CO2) chemoreception is highly relevant to multiple areas of sleep medicine. Patients with sleep-disordered breathing (SDB) may experience hypoxia during sleep, often nightly in an episodic pattern called “chronic intermittent hypoxia” (CIH), which in turn may lead to major cardiovascular complications. Some patients with SDB hypoventilate during sleep and develop hypercapnia. Hypoxemia and hypercapnia mediate, in part, arousal responses to abnormal breathing during sleep. In this chapter, we review the role of O2 and CO2 chemoreceptors in breathing control, the basic physiology of O2 and CO2 sensing, and the role of chemoreceptors in sleep-related breathing disorders, all in a developmental context. This chapter also discusses a variety of disorders associated with sleep problems, from congenital central hypoventilation syndrome (CCHS) to Prader–Willi syndrome (PWS), which are associated with abnormal chemoreceptor function.

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Authors and Affiliations

  1. Division of Pediatric Pulmonary Medicine, Departments of Pediatrics and Physiology and Biophysics, Arkansas Children’s Hospital, 512-17, 1 Children’s Way, Little Rock, AR, 72202, USA

    John L. Carroll MD

  2. Division of Pediatric Pulmonary Medicine,Department of Pediatrics, University of Arkansas for Medical Sciences, 512-17, 1 Children’s Way, Little Rock, AR, 72202, USA

    Supriya K. Jambhekar MD

  3. Division of Pediatric Pulmonary Medicine, Department of Pediatrics, Yale University School of Medicine, 333 Cedar Street, New Haven, CT, 06520, USA

    David F. Donnelly BS, ME, PhD

Authors
  1. John L. Carroll MD
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  2. Supriya K. Jambhekar MD
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  3. David F. Donnelly BS, ME, PhD
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Correspondence to John L. Carroll MD .

Editor information

Editors and Affiliations

  1. Section of Sleep Medicine, Pritzker School of Medicine, Department of Pediatrics, S. Maryland Ave. 5721, Chicago, 60637, Illinois, USA

    Leila Kheirandish-Gozal

  2. Pritzker School of Medicine, Comer Children's Hospital, Department of Pediatrics, S. Maryland Ave. 5721, Chicago, 60637, Illinois, USA

    David Gozal

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Carroll, J.L., Jambhekar, S.K., Donnelly, D.F. (2012). Chemoreceptors, Breathing, and Sleep. In: Kheirandish-Gozal, L., Gozal, D. (eds) Sleep Disordered Breathing in Children. Respiratory Medicine. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-60761-725-9_10

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  • DOI: https://doi.org/10.1007/978-1-60761-725-9_10

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