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Microglia in Neurodegenerative Disorders

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Microglia

Part of the book series: Methods in Molecular Biology ((MIMB,volume 2034))

Abstract

Microglia are the brain’s resident immune cells. Under physiological conditions, they participate in a myriad of processes mainly involved in housekeeping functions that promote tissue homeostasis. However, the triggering of an immune response is a common feature in neurodegenerative disorders. This shift in microglia cells toward a chronically activated phenotype contributing to neuronal dysfunction and cell death is of great interest nowadays. In this chapter, we review the implications of microglia activation in different neurodegenerative disorders.

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Author information

Authors and Affiliations

  1. Department of Neurodegenerative Diseases and Gerontopsychiatry, University of Bonn, Bonn, Germany

    Darío Tejera & Michael T. Heneka

  2. Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany

    Darío Tejera & Michael T. Heneka

Authors
  1. Darío Tejera
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  2. Michael T. Heneka
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Correspondence to Michael T. Heneka .

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Editors and Affiliations

  1. Department of Neurophysiology, Institute of Physiology, Eberhard Karls University of Tübingen, Tübingen, Germany

    Olga Garaschuk

  2. Faculty of Biology, Medicine and Health The University of Manchester, , Center for Basic and Translational Neuroscience, Faculty of Health and Medical Sciences University of Copenhagen Copenhagen, Denmark, Achucarro Center for Neuroscience IKERBASQUE Basque Foundation for Science Bilbao, Spain, Manchester, UK

    Alexei Verkhratsky

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Tejera, D., Heneka, M.T. (2019). Microglia in Neurodegenerative Disorders. In: Garaschuk, O., Verkhratsky, A. (eds) Microglia. Methods in Molecular Biology, vol 2034. Humana, New York, NY. https://doi.org/10.1007/978-1-4939-9658-2_5

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  • DOI: https://doi.org/10.1007/978-1-4939-9658-2_5

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  • Publisher Name: Humana, New York, NY

  • Print ISBN: 978-1-4939-9657-5

  • Online ISBN: 978-1-4939-9658-2

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