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Bioinformatic Strategies for the Genomic and Epigenomic Characterization of Brain Tumors

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Brain Tumor Stem Cells

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1869))

Abstract

Genomics has significantly advanced our knowledge of the biology of brain tumors, and refined our classification over the past 10 years. These advances have relied on the unbiased analysis of large cohorts of brain tumors, where they are clustered in an unbiased manner prior to ascribing clinical and biological features. Indeed, this has resulted in the identification of several layers of heterogeneity not previously appreciated by morphology alone. As such, the classification of unknown samples into known biological subgroups can be performed robustly using either gene expression or DNA methylation profiling.

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Author information

Authors and Affiliations

  1. Division of Haematology/Oncology, Hospital for Sick Children, Toronto, ON, Canada

    Vijay Ramaswamy

  2. Division of Neurosurgery, Hospital for Sick Children, Toronto, ON, Canada

    Michael D. Taylor

  3. Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, ON, Canada

    Vijay Ramaswamy & Michael D. Taylor

Authors
  1. Vijay Ramaswamy
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  2. Michael D. Taylor
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Correspondence to Vijay Ramaswamy .

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Editors and Affiliations

  1. Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, Canada

    Sheila K. Singh

  2. Stem Cell and Cancer Research Institute, McMaster University, Hamilton, ON, Canada

    Chitra Venugopal

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Ramaswamy, V., Taylor, M.D. (2019). Bioinformatic Strategies for the Genomic and Epigenomic Characterization of Brain Tumors. In: Singh, S., Venugopal, C. (eds) Brain Tumor Stem Cells. Methods in Molecular Biology, vol 1869. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8805-1_4

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  • DOI: https://doi.org/10.1007/978-1-4939-8805-1_4

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