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Overview of Serpins and Their Roles in Biological Systems

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Serpins

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1826))

Abstract

Serine protease inhibitors are ubiquitous regulators for a multitude of pathways in humans. The serpins represent an ancient pathway now known to be present in all kingdoms and often regulating central pathways for clotting, immunity, and even cancer in man. Serpins have been present from the time of the dinosaurs and can represent a large proportion of circulating blood proteins. With this introductory chapter, we present an overview of serpins as well as an introduction and overview of the chapters describing the methodology used in the new approaches to understanding their molecular mechanisms of action and their roles in health and disease.

Serpins

Strange structure

Strained structure

Savage, benign

Loops and lines

Suicide and subject

Lethal and abject

Ruling our center

Exit and enter

Extraordinary, divine

Convoluted lines

Concatenated span

Virus

To

Man

Alexandra Lucas, 2017

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Author information

Authors and Affiliations

  1. Centers for Personalized Diagnostics and Immunology, Vaccines and Virotherapy, The Biodesign Institute, Arizona State University, 727 E Tyler St, Tempe, AZ, USA

    Alexandra Lucas, Jordan R. Yaron, Liqiang Zhang & Sriram Ambadapadi

  2. Drug Metabolism and Pharmacokinetics, Pharmacyclics LLC, an AbbVie Company, Sunnyvale, CA, USA

    Sriram Ambadapadi

Authors
  1. Alexandra Lucas
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  2. Jordan R. Yaron
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  3. Liqiang Zhang
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  4. Sriram Ambadapadi
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Corresponding author

Correspondence to Alexandra Lucas .

Editor information

Editors and Affiliations

  1. Biodesign Center for Personalized Diagnostics and Center for Immunotherapy Vaccines and Virotherapy, Arizona State University, Tempe, AZ, USA

    Alexandra Lucas

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Lucas, A., Yaron, J.R., Zhang, L., Ambadapadi, S. (2018). Overview of Serpins and Their Roles in Biological Systems. In: Lucas, A. (eds) Serpins. Methods in Molecular Biology, vol 1826. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-8645-3_1

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  • DOI: https://doi.org/10.1007/978-1-4939-8645-3_1

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-8644-6

  • Online ISBN: 978-1-4939-8645-3

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