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Methods for Polygenic Traits

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Genetic Epidemiology

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1793))

Abstract

An important aspect of public health is disease prediction and health promotion through better targeting of preventive strategies. Well-targeted preventive strategies will eventually decrease burden of diseases and thus precise prediction plays a crucial role in public health. Many investigators put efforts into finding models that improve prediction using known risk factors of diseases. Recently with the overwhelming load of genetic loci discovered for complex diseases through genome-wide association studies (GWAS), much of attention has been focused on the role of these genetic loci to improve prediction models. Genetic loci in solo explain little variance of diseases. It is thus necessary to create new genetic parameters that combine the effect of as many genetic loci as possible. Such new parameters aim to better distinguish individuals who will develop a disease from those who will not. In this chapter, various polygenic methods that use multiple genetic loci to directly or indirectly improve precision of genetic prediction are discussed.

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Author information

Authors and Affiliations

  1. Department of Epidemiology and Biostatistics (inc MRC-HPA Centre), School of Public Health, Imperial College London, London, UK

    Raha Pazoki

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  1. Raha Pazoki
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Correspondence to Raha Pazoki .

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Editors and Affiliations

  1. Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina, Greece

    Evangelos Evangelou

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Pazoki, R. (2018). Methods for Polygenic Traits. In: Evangelou, E. (eds) Genetic Epidemiology. Methods in Molecular Biology, vol 1793. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7868-7_10

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  • DOI: https://doi.org/10.1007/978-1-4939-7868-7_10

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  • Publisher Name: Humana Press, New York, NY

  • Print ISBN: 978-1-4939-7867-0

  • Online ISBN: 978-1-4939-7868-7

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