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Developmental Origins of Stress and Psychiatric Disorders

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Investigations of Early Nutrition Effects on Long-Term Health

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1735))

Abstract

Over the last few decades, evidence has emerged that the pathogenesis of psychiatric disorders such as schizophrenia can involve perturbations of the hypothalamic-pituitary-adrenal (HPA) axis and other neuroendocrine systems. Variations in the manifestation of these effects could be related to differences in clinical symptoms between affected individuals and to differences in treatment response. Such effects can also arise from the complex interaction between genes and environmental factors. Here, we review the effects of maternal stress on abnormalities in HPA axis regulation and the development of psychiatric disorders such as schizophrenia. Studies in this area may prove critical for increasing our understanding of the multidimensional nature of mental disorders and could lead to the development of improved diagnostics and novel therapeutic approaches for treating individuals who suffer from these conditions.

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Authors and Affiliations

  1. Taunton and somerset NHS trust, Musgrove Park Hospital, Taunton, UK

    Francesca L. Guest

  2. Laboratory of Neuroproteomics, Institute of Biology, University of Campinas, Campinas, Brazil

    Paul C. Guest

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  1. Francesca L. Guest
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  1. Debden, Essex, United Kingdom

    Paul C. Guest

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Guest, F.L., Guest, P.C. (2018). Developmental Origins of Stress and Psychiatric Disorders. In: Guest, P. (eds) Investigations of Early Nutrition Effects on Long-Term Health. Methods in Molecular Biology, vol 1735. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7614-0_3

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  • DOI: https://doi.org/10.1007/978-1-4939-7614-0_3

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