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Microbiome: Allergic Diseases of Childhood

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Mechanisms Underlying Host-Microbiome Interactions in Pathophysiology of Human Diseases

Part of the book series: Physiology in Health and Disease ((PIHD))

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Abstract

Recent interest has focused on the microbiome modulating immune responses, and thus playing a significant role in the development of many diseases, including allergic responses. “Dysbiosis,” alteration in the normal microbiome, does have an effect on inflammation and may also influence the course of the disease. In this chapter, we discuss the influence of the microbiome on common pediatric allergic diseases: food allergy, atopic dermatitis, asthma, and allergic rhinitis. These diseases stem from common immune mechanisms, and are part of a progressive “Atopic March” phenomenon, which will be introduced in this chapter. We explain how the microbiome is related to allergic diseases in both human and murine studies. Studying the microbiome in the context of allergic diseases has the potential to elucidate ways of manipulating the microbiome in disease in general. With further studies in the field, we may be able to modulate the immune response and the disease course by understanding the relationship between the microbiome and the immune response.

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Authors and Affiliations

  1. Koc University School of Medicine, Istanbul, Turkey

    Ozge Nur Aktas

  2. Department of Microbiology and Immunology, University of Illinois at Chicago, Chicago, IL, USA

    Benjamin Turturice & Patricia W. Finn

  3. Division of Nephrology, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA

    David L. Perkins

  4. Department of Surgery, University of Illinois at Chicago, Chicago, IL, USA

    David L. Perkins

  5. Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, USA

    David L. Perkins

  6. Division of Pulmonary, Critical Care, Sleep, and Allergy, Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA

    Patricia W. Finn

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  1. Ozge Nur Aktas
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Correspondence to David L. Perkins .

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Editors and Affiliations

  1. Division of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

    Jun Sun

  2. Division of Gastroenterology and Hepatology, Department of Medicine, University of Illinois at Chicago, Chicago, Illinois, USA

    Pradeep K. Dudeja

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Aktas, O.N., Turturice, B., Perkins, D.L., Finn, P.W. (2018). Microbiome: Allergic Diseases of Childhood. In: Sun, J., Dudeja, P. (eds) Mechanisms Underlying Host-Microbiome Interactions in Pathophysiology of Human Diseases. Physiology in Health and Disease. Springer, Boston, MA. https://doi.org/10.1007/978-1-4939-7534-1_2

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