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Emerging Concepts in Innate Immunity

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Innate Immune Activation

Part of the book series: Methods in Molecular Biology ((MIMB,volume 1714))

Abstract

This review introduces recent concepts in innate immunity highlighting some of the latest exciting findings. These include: the discovery of the initiator of pyroptosis, Gasdermin D, and mechanisms of inflammatory caspases in innate immune signaling; the formation of oligomeric signalosomes downstream of innate immune receptors; mechanisms that shape innate immune responses, such as cellular homeostasis, cell metabolism, and pathogen viability; rapid methods of cell-to-cell communication; the interplay between the host and its microbiome and the concept of innate immunological memory. Furthermore, we discuss open questions and illustrate how technological advances, such as CRISPR/Cas9, may provide important answers for outstanding questions in the field of innate immunity.

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Authors and Affiliations

  1. Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA

    Karin Pelka

  2. Inflammation Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia

    Dominic De Nardo

  3. Department of Medical Biology, The University of Melbourne, Parkville, Victoria, Australia

    Dominic De Nardo

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  1. Karin Pelka
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  2. Dominic De Nardo
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Correspondence to Dominic De Nardo .

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  1. Inflammation Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia

    Dominic De Nardo

  2. Chemical Biology Division, The Walter & Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia

    Christine M De Nardo

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Pelka, K., De Nardo, D. (2018). Emerging Concepts in Innate Immunity. In: De Nardo, D., De Nardo, C. (eds) Innate Immune Activation. Methods in Molecular Biology, vol 1714. Humana Press, New York, NY. https://doi.org/10.1007/978-1-4939-7519-8_1

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