Abstract
Bone marrow biopsies and aspirates from patients undergoing various forms of treatment can show a variety of histological and cytological findings, and it is therefore imperative that pathologists understand the array of associated therapy-related effects. Patients receiving induction chemotherapy for acute leukemia frequently have bone marrow aspirates and/or biopsies at specific intervals, allowing the pathologist to observe the immediate and long-term effects of the treatment regimen (Table 3.1).
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Islam A, Catovsky D, Galton DAG. Histological study of bone marrow regeneration following chemotherapy for acute myeloid leukemia and chronic granulocytic leukemia in blast transformation. Br J Haematol. 1980;45:535–40.
Dick FR, Burns CP, Weiner GJ, Heckman KD. Bone marrow morphology during induction phase of therapy for acute myeloid leukemia (AML). Hematol Pathol. 1995;9:95–106.
Kushwaha R, Kumar A, Aggrawal K, Nigam N, Kumar A. Post chemotherapy blood and bone marrow regenerative changes in childhood acute lymphoblastic leukemia: a prospective study. Indian J Pathol Microbiol. 2014;57:72–7. https://doi.org/10.4103/0377–4929.130903.
Campbell LJ, Maher DW, Tay DL, Boyd AW, Rockman S, McGrath K, et al. Marrow proliferation and the appearance of giant neutrophils in response to recombinant human granulocyte colony stimulating factor (rhG-CSF). Br J Haematol. 1992;80:298–304.
Ryder JW, Lazarus HM, Farhi DC. Bone marrow and blood findings after marrow transplantation and rhGM-CSF therapy. Am J Clin Pathol. 1992;97:631–7.
Schmitz LL, McClure JS, litz CE, Dayton V, Weisdorf DJ, Parkin JL, Brunning RD. Morphologic and quantitative changes in blood and marrow cells following growth factor therapy. Am J Clin Pathol. 1994;101:67–75.
Harris AC, Todd WM, Hackney MH, Ben-Ezra J. Bone marrow changes associated with recombinant granulocyte-macrophage and granulocyte colony-stimulating factors: discrimination of granulocytic regeneration. Arch Pathol Lab Med. 1994;118:624–9.
Raynaud P, Caulet-Maugendre S, Foussard C, Salles G, Moreau A, Rossi JF, et al. GOELAMS Group. T-cell lymphoid aggregates in bone marrow after rituximab therapy for B-cell follicular lymphoma: a marker of therapeutic efficacy? Hum Pathol. 2008;39:194–200.
Miyauchi J, Ohyashiki K, Inatomi Y, Toyama K. Neutrophil secondary-granule deficiency as a hallmark of all-trans retinoic acid-induced differentiation of acute promyelocytic leukemia cells. Blood. 1997;90:803–13.
Hasserjian RP, Boecklin F, Parker S, Chase A, Dhar S, Zaiac M, et al. ST1571 (imatinib mesylate) reduces bone marrow cellularity and normalizes morphologic features irrespective of cytogenetic response. Am J Clin Pathol. 2002;117:360–7.
Frater JL, Tallman MS, Variakojis D, Druker BJ, Resta D, Riley MB, et al. Chronic myeloid leukemia following therapy with imatinib mesylate (Gleevec). Bone marrow histopathology and correlation with genetic status. Am J Clin Pathol. 2003;119:833–41.
McNamara C, Grigg A, Szer J, Roberts A, Campbell L, Hoyt R, et al. Morphological effects of imatinib mesylate (STI571) on the bone marrow and blood of patients with Philadelphia chromosome (Ph) positive chronic myeloid leukaemia. Clin Lab Haematol. 2003;25:119–25.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2018 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Kurzer, J.H., Weinberg, O.K. (2018). Post-therapy Marrow Changes. In: George, T., Arber, D. (eds) Atlas of Bone Marrow Pathology. Atlas of Anatomic Pathology. Springer, New York, NY. https://doi.org/10.1007/978-1-4939-7469-6_3
Download citation
DOI: https://doi.org/10.1007/978-1-4939-7469-6_3
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4939-7467-2
Online ISBN: 978-1-4939-7469-6
eBook Packages: MedicineMedicine (R0)